Creation of a novel class of potent and selective MutT Homolog 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design. Read more about Creation of a novel class of potent and selective MutT Homolog 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design.
Structural and histone binding studies of the chromo barrel domain of TIP60. Read more about Structural and histone binding studies of the chromo barrel domain of TIP60.
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation. Read more about Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
New opportunities for kinase drug repurposing and target discovery. Read more about New opportunities for kinase drug repurposing and target discovery.
Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders. Read more about Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders.
Quantitative characterization of bivalent probes for a dual bromodomain protein, Transcription Initiation Factor TFIID subunit 1, TAF1. Read more about Quantitative characterization of bivalent probes for a dual bromodomain protein, Transcription Initiation Factor TFIID subunit 1, TAF1.
Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. Read more about Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.
Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. Read more about Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Therapeutics discovery: From bench to first in-human trials. Read more about Therapeutics discovery: From bench to first in-human trials.
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Read more about Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.
