Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders. Read more about Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders.
Quantitative characterization of bivalent probes for a dual bromodomain protein, Transcription Initiation Factor TFIID subunit 1, TAF1. Read more about Quantitative characterization of bivalent probes for a dual bromodomain protein, Transcription Initiation Factor TFIID subunit 1, TAF1.
Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. Read more about Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.
Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. Read more about Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Therapeutics discovery: From bench to first in-human trials. Read more about Therapeutics discovery: From bench to first in-human trials.
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Read more about Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.
Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. Read more about Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces. Read more about Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces.
Halogen-aromatic π-interactions modulate inhibitor residence time. Read more about Halogen-aromatic π-interactions modulate inhibitor residence time.
