Structural Complexity in the KCTD Family of Cullin3-Dependent E3 Ubiquitin Ligases. Read more about Structural Complexity in the KCTD Family of Cullin3-Dependent E3 Ubiquitin Ligases.
Discovery of a highly selective cell-active inhibitor of KDM2/7. Read more about Discovery of a highly selective cell-active inhibitor of KDM2/7.
Synthesis and Demonstration of the Biological Relevance of sp(3) -rich Scaffolds Distantly Related to Natural Product Frameworks. Read more about Synthesis and Demonstration of the Biological Relevance of sp(3) -rich Scaffolds Distantly Related to Natural Product Frameworks.
Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Read more about Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.
Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14. Read more about Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14.
A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. Read more about A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.
Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin. Read more about Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin.
WD40 repeat domain proteins: a novel target class? Read more about WD40 repeat domain proteins: a novel target class?
Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action. Read more about Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action.
Characterization of three druggable hotspots in the Aurora-A/TPX2 interaction using biochemical, biophysical and fragment-based approaches. Read more about Characterization of three druggable hotspots in the Aurora-A/TPX2 interaction using biochemical, biophysical and fragment-based approaches.
