Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin. Read more about Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin.
WD40 repeat domain proteins: a novel target class? Read more about WD40 repeat domain proteins: a novel target class?
Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action. Read more about Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action.
Characterization of three druggable hotspots in the Aurora-A/TPX2 interaction using biochemical, biophysical and fragment-based approaches. Read more about Characterization of three druggable hotspots in the Aurora-A/TPX2 interaction using biochemical, biophysical and fragment-based approaches.
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. Read more about Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.
Conformational dynamics of the TTD-PHD histone reader module of UHRF1 reveals multiple histone binding states, allosteric regulation and druggability. Read more about Conformational dynamics of the TTD-PHD histone reader module of UHRF1 reveals multiple histone binding states, allosteric regulation and druggability.
The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery. Read more about The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.
Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Read more about Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Read more about Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers. Read more about Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
