Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. Read more about Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Therapeutics discovery: From bench to first in-human trials. Read more about Therapeutics discovery: From bench to first in-human trials.
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Read more about Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.
Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. Read more about Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces. Read more about Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces.
Halogen-aromatic π-interactions modulate inhibitor residence time. Read more about Halogen-aromatic π-interactions modulate inhibitor residence time.
Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities. Read more about Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.
Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Read more about Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
A novel INS mutation in a family with MODY: variable insulin secretion and putative mechanisms. Read more about A novel INS mutation in a family with MODY: variable insulin secretion and putative mechanisms.
