Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Read more about Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Read more about A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.
Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1. Read more about Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1.
Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor. Read more about Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor.
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Read more about Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
2-Amino-2, 3-Dihydro-1H-Indene-5-Carboxamide-Based Discoidin Domain Receptors 1 (DDR1) Inhibitors: Design, Synthesis, and In Vivo Anti-pancreatic Cancer Efficacy. Read more about 2-Amino-2, 3-Dihydro-1H-Indene-5-Carboxamide-Based Discoidin Domain Receptors 1 (DDR1) Inhibitors: Design, Synthesis, and In Vivo Anti-pancreatic Cancer Efficacy.
Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Read more about Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.
Identification and characterization of the first fragment hits for SETDB1 Tudor domain. Read more about Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain. Read more about Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
