Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Read more about Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.
Identification and characterization of the first fragment hits for SETDB1 Tudor domain. Read more about Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain. Read more about Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines. Read more about Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines.
Evaluation of linker length effects on a BET bromodomain probe. Read more about Evaluation of linker length effects on a BET bromodomain probe.
The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions. Read more about The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Read more about Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.
Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase. Read more about Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase.
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition. Read more about E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.
