Structural analyses reveal that MBD3 is a methylated-CG binder. Read more about Structural analyses reveal that MBD3 is a methylated-CG binder.
Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Read more about Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.
A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase. Read more about A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.
Crystal structure of human RIOK2 bound to a specific inhibitor. Read more about Crystal structure of human RIOK2 bound to a specific inhibitor.
Discovery of Pyrrolo[3,2-d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell Active Inhibitors of P300/CBP-Associated Factor Bromodomain. Read more about Discovery of Pyrrolo[3,2-d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
A chemical toolbox for the study of bromodomains and epigenetic signaling. Read more about A chemical toolbox for the study of bromodomains and epigenetic signaling.
Discovery of selective activators of PRC2 mutant EED-I363M. Read more about Discovery of selective activators of PRC2 mutant EED-I363M.
Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase. Read more about Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping. Read more about Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.
A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction. Read more about A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction.
