Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. Read more about Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity. Read more about Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.
Targeting Pim Kinases and DAPK3 to Control Hypertension. Read more about Targeting Pim Kinases and DAPK3 to Control Hypertension.
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. Read more about LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data. Read more about Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data.
The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration. Read more about The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration.
GW779439X and its pyrazolopyridazine derivatives inhibit the serine/threonine kinase Stk1 and act as antibiotic adjuvants against β-lactam-resistant Staphylococcus aureus. Read more about GW779439X and its pyrazolopyridazine derivatives inhibit the serine/threonine kinase Stk1 and act as antibiotic adjuvants against β-lactam-resistant Staphylococcus aureus.
Design, Synthesis and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as Dual Inhibitors of Discoidin Domain Receptor 1 and 2 (DDR1/2). Read more about Design, Synthesis and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as Dual Inhibitors of Discoidin Domain Receptor 1 and 2 (DDR1/2).
Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept. Read more about Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept.
Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. Read more about Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains.
