Rapid covalent-probe discovery by electrophile-fragment screening. Read more about Rapid covalent-probe discovery by electrophile-fragment screening.
The dynamic conformational landscape of the protein methyltransferase SETD8. Read more about The dynamic conformational landscape of the protein methyltransferase SETD8.
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma. Read more about ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism. Read more about Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
Targeting protein methylation: from chemical tools to precision medicines. Read more about Targeting protein methylation: from chemical tools to precision medicines.
Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy. Read more about Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy.
15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism. Read more about 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Read more about Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).
Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3- b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity. Read more about Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3- b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Read more about C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
