Substrate reduction therapy for inborn errors of metabolism. Read more about Substrate reduction therapy for inborn errors of metabolism.
High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging. Read more about High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.
Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. Read more about Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells. Read more about Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells.
A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation. Read more about A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation.
PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Read more about PRMT5 inhibition disrupts splicing and stemness in glioblastoma.
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Read more about A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.
Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors. Read more about Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Read more about Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells. Read more about Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.
