Structure-Activity Relationship of USP5 Inhibitors. Read more about Structure-Activity Relationship of USP5 Inhibitors.
The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif. Read more about The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif.
Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells. Read more about Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. Read more about Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2). Read more about Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2).
Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status. Read more about Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status.
The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface. Read more about The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface.
Selectivity aspects of activity-based (chemical) probes. Read more about Selectivity aspects of activity-based (chemical) probes.
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance. Read more about Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Read more about A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
