Crowdsourced mapping of unexplored target space of kinase inhibitors. Read more about Crowdsourced mapping of unexplored target space of kinase inhibitors.
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. Read more about Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Read more about Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Read more about Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Read more about Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. Read more about Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
The structural basis of fatty acid elongation by the ELOVL elongases. Read more about The structural basis of fatty acid elongation by the ELOVL elongases.
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source. Read more about Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source.
Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation. Read more about Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors. Read more about The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.
