The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase. Read more about The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
Resistance to kinase inhibition through shortened target engagement. Read more about Resistance to kinase inhibition through shortened target engagement.
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog. Read more about Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.
Stopping pandemics before they start: Lessons learned from SARS-CoV-2. Read more about Stopping pandemics before they start: Lessons learned from SARS-CoV-2.
Post-transcriptional and Post-translational Modifications of Primary Cilia: How to Fine Tune Your Neuronal Antenna. Read more about Post-transcriptional and Post-translational Modifications of Primary Cilia: How to Fine Tune Your Neuronal Antenna.
PRMT5 regulates ATF4 transcript splicing and oxidative stress response. Read more about PRMT5 regulates ATF4 transcript splicing and oxidative stress response.
Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Read more about Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.
Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes. Read more about Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes.
PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade. Read more about PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade.
Validating Small Molecule Chemical Probes for Biological Discovery. Read more about Validating Small Molecule Chemical Probes for Biological Discovery.
