Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. Read more about Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes. Read more about High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
Production of Recombinant PRMT Proteins using the Baculovirus Expression Vector System. Read more about Production of Recombinant PRMT Proteins using the Baculovirus Expression Vector System.
Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors. Read more about Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.
Trends in kinase drug discovery: targets, indications and inhibitor design. Read more about Trends in kinase drug discovery: targets, indications and inhibitor design.
The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells. Read more about The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells.
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase. Read more about Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.
Assessing reversible and irreversible binding effects of kinase covalent inhibitors through ADP-Glo assays. Read more about Assessing reversible and irreversible binding effects of kinase covalent inhibitors through ADP-Glo assays.
Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells. Read more about Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells.
Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1. Read more about Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1.
