Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. Read more about Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells. Read more about Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells.
A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation. Read more about A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation.
PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Read more about PRMT5 inhibition disrupts splicing and stemness in glioblastoma.
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Read more about A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.
Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors. Read more about Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Read more about Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells. Read more about Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.
Reply to: Binding site for MDL-801 on SIRT6. Read more about Reply to: Binding site for MDL-801 on SIRT6.
Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function. Read more about Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function.
