Exploring protein hotspots by optimized fragment pharmacophores. Read more about Exploring protein hotspots by optimized fragment pharmacophores.
Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series. Read more about Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series.
Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors. Read more about Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors.
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. Read more about Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. Read more about Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern. Read more about Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern.
Controlling the Covalent Reactivity of a Kinase Inhibitor with Light. Read more about Controlling the Covalent Reactivity of a Kinase Inhibitor with Light.
Crowdsourced mapping of unexplored target space of kinase inhibitors. Read more about Crowdsourced mapping of unexplored target space of kinase inhibitors.
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. Read more about Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Read more about Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.
