How many kinases are druggable? A review of our current understanding. Read more about How many kinases are druggable? A review of our current understanding.
Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation. Read more about Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation.
The RavA-ViaA chaperone complex modulates bacterial persistence through its association with the fumarate reductase enzyme. Read more about The RavA-ViaA chaperone complex modulates bacterial persistence through its association with the fumarate reductase enzyme.
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells. Read more about RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.
Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors. Read more about Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Discovery of Nedd4 auto-ubiquitination inhibitors. Read more about Discovery of Nedd4 auto-ubiquitination inhibitors.
The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence. Read more about The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence.
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Read more about Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen. Read more about Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.
A machine learning and live-cell imaging tool kit uncovers small molecules induced phospholipidosis. Read more about A machine learning and live-cell imaging tool kit uncovers small molecules induced phospholipidosis.
