RAS and PP2A activities converge on epigenetic gene regulation. Read more about RAS and PP2A activities converge on epigenetic gene regulation.
Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators. Read more about Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.
Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor. Read more about Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor.
Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells. Read more about Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells.
Reference compounds for characterizing cellular injury in high-content cellular morphology assays. Read more about Reference compounds for characterizing cellular injury in high-content cellular morphology assays.
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum. Read more about Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.
Discovery of Nanomolar DCAF1 Small Molecule Ligands. Read more about Discovery of Nanomolar DCAF1 Small Molecule Ligands.
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. Read more about Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. Read more about A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi.
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells. Read more about Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells.
