Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. Read more about Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration.
Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB. Read more about Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB.
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Read more about Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.
Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors. Read more about Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3. Read more about Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3.
Atg8 family proteins, LIR/AIM motifs and other interaction modes. Read more about Atg8 family proteins, LIR/AIM motifs and other interaction modes.
Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle. Read more about Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle.
ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation. Read more about ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation.
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. Read more about Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Read more about Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
