Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle. Read more about Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle.
ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation. Read more about ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation.
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. Read more about Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Read more about Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Photosensitization enables Pauson-Khand-type reactions with nitrenes. Read more about Photosensitization enables Pauson-Khand-type reactions with nitrenes.
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Read more about Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. Read more about Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. Read more about Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
Kinetic characterization of human mRNA guanine-N7 methyltransferase. Read more about Kinetic characterization of human mRNA guanine-N7 methyltransferase.
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity. Read more about Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
