Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation. Read more about Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes. Read more about Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.
Thermal denaturation assays in chemical biology. Read more about Thermal denaturation assays in chemical biology.
Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini. Read more about Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini.
Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates. Read more about Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.
7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. Read more about 7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.
Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Read more about Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
Druggability of methyl-lysine binding sites. Read more about Druggability of methyl-lysine binding sites.
Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases. Read more about Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases.
Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis. Read more about Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
