Publications

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Displaying 51 - 100 of 2162

2021

May 2021

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Abi Saad MJ, Alfano C, Almeida FCL, Alshamleh I, de Amorim GC, Anderson TK, Anobom CD, Anorma C, Bains JK, Bax A, Blackledge M, Blechar J, Böckmann A, Brigandat L, Bula A, Bütikofer M, Camacho-Zarco AR, Carlomagno T, Caruso IP, Ceylan B, Chaikuad A, Chu F, Cole L, Crosby MG, de Jesus V, Dhamotharan K, Felli IC, Ferner J, Fleischmann Y, Fogeron ML, Fourkiotis NK, Fuks C, Fürtig B, Gallo A, Gande SL, Gerez JA, Ghosh D, Gomes-Neto F, Gorbatyuk O, Guseva S, Hacker C, Häfner S, Hao B, Hargittay B, Henzler-Wildman K, Hoch JC, Hohmann KF, Hutchison MT, Jaudzems K, Jović K, Kaderli J, Kalniņš G, Kaņepe I, Kirchdoerfer RN, Kirkpatrick J, Knapp S, Krishnathas R, Kutz F, Zur Lage S, Lambertz R, Lang A, Laurents D, Lecoq L, Linhard V, Löhr F, Malki A, Bessa LM, Martin RW, Matzel T, Maurin D, McNutt SW, Mebus-Antunes NC, Meier BH, Meiser N, Mompeán M, Monaca E, Montserret R, Mariño Perez L, Moser C, Muhle-Goll C, Neves-Martins TC, Ni X, Norton-Baker B, Pierattelli R, Pontoriero L, Pustovalova Y, Ohlenschläger O, Orts J, Da Poian AT, Pyper DJ, Richter C, Riek R, Rienstra CM, Robertson A, Pinheiro AS, Sabbatella R, Salvi N, Saxena K, Schulte L, Schiavina M, Schwalbe H, Silber M, Almeida MDS, Sprague-Piercy MA, Spyroulias GA, Sreeramulu S, Tants JN, Tārs K, Torres F, Töws S, Treviño MÁ, Trucks S, Tsika AC, Varga K, Wang Y, Weber ME, Weigand JE, Wiedemann C, Wirmer-Bartoschek J, Wirtz Martin MA, Zehnder J, Hengesbach M, Schlundt A
Front Mol Biosci 8:653148 . doi: 10.3389/fmolb.2021.653148
Publication date: May 28, 2021
PMID: 34041264
BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation.
Vershinin Z, Feldman M, Werner T, Weil LE, Kublanovsky M, Abaev-Schneiderman E, Sklarz M, Lam EYN, Alasad K, Picaud S, Rotblat B, McAdam RA, Chalifa-Caspi V, Bantscheff M, Chapman T, Lewis HD, Filippakopoulos P, Dawson MA, Grandi P, Prinjha RK, Levy D
Sci Adv 7(22): . doi: 10.1126/sciadv.abf5374
Publication date: May 28, 2021
PMID: 34039605
Exploring protein hotspots by optimized fragment pharmacophores.
Bajusz D, Wade WS, Satała G, Bojarski AJ, Ilaš J, Ebner J, Grebien F, Papp H, Jakab F, Douangamath A, Fearon D, von Delft F, Schuller M, Ahel I, Wakefield A, Vajda S, Gerencsér J, Pallai P, Keserű GM
Nat Commun 12(1):3201 . doi: 10.1038/s41467-021-23443-y
Publication date: May 27, 2021
PMID: 34045440
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
Conde J, Pumroy RA, Baker C, Rodrigues T, Guerreiro A, Sousa BB, Marques MC, de Almeida BP, Lee S, Leites EP, Picard D, Samanta A, Vaz SH, Sieglitz F, Langini M, Remke M, Roque R, Weiss T, Weller M, Liu Y, Han S, Corzana F, Morais VA, Faria CC, Carvalho T, Filippakopoulos P, Snijder B, Barbosa-Morais NL, Moiseenkova-Bell VY, Bernardes GJL
ACS Cent Sci 7(5):868-881 . doi: 10.1021/acscentsci.1c00070
Publication date: May 26, 2021
PMID: 34079902
Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Chi G, Ebenhoch R, Man H, Tang H, Tremblay LE, Reggiano G, Qiu X, Bohstedt T, Liko I, Almeida FG, Garneau AP, Wang D, McKinley G, Moreau CP, Bountra KD, Abrusci P, Mukhopadhyay SMM, Fernandez-Cid A, Slimani S, Lavoie JL, Burgess-Brown NA, Tehan B, DiMaio F, Jazayeri A, Isenring P, Robinson CV, Dürr KL
EMBO J e107294 . doi: 10.15252/embj.2020107294
Publication date: May 25, 2021
PMID: 34031912
Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies.
Resetca D, MacDonald AS, Kenney TMG, Wei Y, Arrowsmith CH, Raught B, Penn LZ
Methods Mol Biol 2318:45-67 . doi: 10.1007/978-1-0716-1476-1_4
Publication date: May 22, 2021
PMID: 34019286
Editorial: Structural Studies of Protein Complexes in Signaling Pathways.
Prischi F, Filippakopoulos P
Front Mol Biosci 8:641932 . doi: 10.3389/fmolb.2021.641932
Publication date: May 18, 2021
PMID: 33996897
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.
Dölle A, Adhikari B, Krämer A, Weckesser J, Berner N, Berger LM, Diebold M, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Gebel J, Löhr F, Dötsch V, Eilers M, Heinzlmeir S, Kuster B, Sotriffer C, Wolf E, Knapp S
J Med Chem . doi: 10.1021/acs.jmedchem.1c00146
Publication date: May 13, 2021
PMID: 33980013
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions.
Willems S, Gellrich L, Chaikuad A, Kluge S, Werz O, Heering J, Knapp S, Lorkowski S, Schubert-Zsilavecz M, Merk D
Cell Chem Biol . doi: 10.1016/j.chembiol.2021.04.019
Publication date: May 12, 2021
PMID: 33989565
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy.
Wanior M, Krämer A, Knapp S, Joerger AC
Oncogene . doi: 10.1038/s41388-021-01781-x
Publication date: May 3, 2021
PMID: 33941852

April 2021

Hepatitis B virus resistance to tenofovir: fact or fiction? A systematic literature review and structural analysis of drug resistance mechanisms.
Mokaya J, McNaughton AL, Bester PA, Goedhals D, Barnes E, Marsden BD, Matthews PC
Wellcome Open Res 5:151 . doi: 10.12688/wellcomeopenres.15992.1
Publication date: April 20, 2021
PMID: 33869791
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex.
Khalili Yazdi A, Li F, Devkota K, Perveen S, Ghiabi P, Hajian T, Bolotokova A, Vedadi M
SLAS Discov 24725552211008863 . doi: 10.1177/24725552211008863
Publication date: April 19, 2021
PMID: 33874769
Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.
Ni X, Schröder M, Olieric V, Sharpe ME, Hernandez-Olmos V, Proschak E, Merk D, Knapp S, Chaikuad A
ACS Med Chem Lett 12(4):603-609 . doi: 10.1021/acsmedchemlett.0c00684
Publication date: April 8, 2021
PMID: 33850605
Structures of chromatin modulators in complex with nucleosome.
Min J, Liu K
Curr Opin Chem Biol 63:105-114 . doi: 10.1016/j.cbpa.2021.02.018
Publication date: April 3, 2021
PMID: 33823458
Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.
Schierle S, Chaikuad A, Lillich FF, Ni X, Woltersdorf S, Schallmayer E, Renelt B, Ronchetti R, Knapp S, Proschak E, Merk D
J Med Chem . doi: 10.1021/acs.jmedchem.1c00235
Publication date: April 1, 2021
PMID: 33793232

March 2021

Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells.
Matossian MD, Elliott S, Rhodes LV, Martin EC, Hoang VT, Burks HE, Zuercher WJ, Drewry DH, Collins-Burow BM, Burow ME
Oncol Lett 21(5):380 . doi: 10.3892/ol.2021.12641
Publication date: March 30, 2021
PMID: 33777204
Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells.
Luparello C, Cruciata I, Joerger AC, Ocasio CA, Jones R, Tareque RK, Bagley MC, Spencer J, Walker M, Austin C, Ferrara T, D Oca P, Bellina R, Branni R, Caradonna F
Int J Mol Sci 22(7): . doi: 10.3390/ijms22073410
Publication date: March 26, 2021
PMID: 33810274
Structural basis for RNA 3'-end recognition by the PIWIL2 PAZ domain.
Li Q, Dong A, Zhu Z, Zhang J, Li Y, Xu C
Biochem Biophys Res Commun 553:187-190 . doi: 10.1016/j.bbrc.2021.03.080
Publication date: March 25, 2021
PMID: 33774220
Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review.
Matossian MD, Wells CI, Zuercher WJ, Collins-Burow BM, Drewry DH, Burow ME
Curr Med Chem . doi: 10.2174/0929867328666210322101749
Publication date: March 21, 2021
PMID: 33749548
Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants.
Ni X, Londregan AT, Owen DR, Knapp S, Chaikuad A
ACS Chem Biol . doi: 10.1021/acschembio.0c00960
Publication date: March 21, 2021
PMID: 33749253
The Promise and Peril of Chemical Probe Negative Controls.
Lee J, Schapira M
ACS Chem Biol . doi: 10.1021/acschembio.1c00036
Publication date: March 21, 2021
PMID: 33745272
Protein arginine methylation: from enigmatic functions to therapeutic targeting.
Wu Q, Schapira M, Arrowsmith CH, Barsyte-Lovejoy D
Nat Rev Drug Discov . doi: 10.1038/s41573-021-00159-8
Publication date: March 19, 2021
PMID: 33742187
Structure and activation mechanism of the human liver-type glutaminase GLS2.
Ferreira IM, Edwin N Quesñay J, Bastos AC, Rodrigues CT, Vollmar M, Krojer T, Strain-Damerell C, Burgess-Brown NA, von Delft F, Yue WW, Dias SM, Ambrosio AL
Biochimie . doi: 10.1016/j.biochi.2021.03.009
Publication date: March 18, 2021
PMID: 33746066
Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
Mackinnon SR, Krojer T, Foster WR, Diaz-Saez L, Tang M, Huber KVM, von Delft F, Lai K, Brennan PE, Arruda Bezerra G, Yue WW
ACS Chem Biol . doi: 10.1021/acschembio.0c00498
Publication date: March 16, 2021
PMID: 33724769
Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function.
Cribbs AP, Filippakopoulos P, Philpott M, Wells G, Penn H, Oerum H, Valge-Archer V, Feldmann M, Oppermann U
Front Immunol 12:626255 . doi: 10.3389/fimmu.2021.626255
Publication date: March 16, 2021
PMID: 33717143
Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy.
Di Rita A, Angelini DF, Maiorino T, Caputo V, Cascella R, Kumar M, Tiberti M, Lambrughi M, Wesch N, Löhr F, Dötsch V, Carinci M, D'Acunzo P, Chiurchiù V, Papaleo E, Rogov VV, Giardina E, Battistini L, Strappazzon F
Cell Death Differ . doi: 10.1038/s41418-021-00766-3
Publication date: March 15, 2021
PMID: 33723372
7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a Cut and Glue Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors.
Karatas M, Chaikuad A, Berger B, Kubbutat MHG, Totzke F, Knapp S, Kunick C
Molecules 26(6): . doi: 10.3390/molecules26061611
Publication date: March 14, 2021
PMID: 33799460
Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.
Sugata K, Matsunaga Y, Yamashita Y, Nakatsugawa M, Guo T, Halabelian L, Ohashi Y, Saso K, Rahman MA, Anczurowski M, Wang CH, Murata K, Saijo H, Kagoya Y, Ly D, Burt BD, Butler MO, Mak TW, Hirano N
Nat Biotechnol . doi: 10.1038/s41587-021-00836-4
Publication date: March 1, 2021
PMID: 33649568
Reply to: Binding site for MDL-801 on SIRT6.
Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Shen H, Xu Y, Chen G, Zhang J
Nat Chem Biol . doi: 10.1038/s41589-021-00750-5
Publication date: March 1, 2021
PMID: 33649600

February 2021

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
Devkota K, Schapira M, Perveen S, Yazdi AK, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M
bioRxiv . doi: 10.1101/2021.02.19.424337
Publication date: February 19, 2021
PMID: 33619486
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Němec V, Maier L, Berger BT, Chaikuad A, Drápela S, Souček K, Knapp S, Paruch K
Eur J Med Chem 215:113299 . doi: 10.1016/j.ejmech.2021.113299
Publication date: February 18, 2021
PMID: 33636538
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.
Shen Y, Li F, Szewczyk MM, Halabelian L, Chau I, Eram MS, Dela Seña C, Park KS, Meng F, Chen H, Zeng H, McLeod D, Zepeda-Velázquez CA, Campbell RM, Mader MM, Watson BM, Schapira M, Arrowsmith CH, Al-Awar R, Barsyte-Lovejoy D, Kaniskan HÜ, Brown PJ, Vedadi M, Jin J
J Med Chem . doi: 10.1021/acs.jmedchem.0c02160
Publication date: February 16, 2021
PMID: 33591753
A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation.
Ostrop J, Zwiggelaar RT, Terndrup Pedersen M, Gerbe F, Bösl K, Lindholm HT, Díez-Sánchez A, Parmar N, Radetzki S, von Kries JP, Jay P, Jensen KB, Arrowsmith C, Oudhoff MJ
Front Cell Dev Biol 8:618552 . doi: 10.3389/fcell.2020.618552
Publication date: February 13, 2021
PMID: 33575256
PRMT5 inhibition disrupts splicing and stemness in glioblastoma.
Sachamitr P, Ho JC, Ciamponi FE, Ba-Alawi W, Coutinho FJ, Guilhamon P, Kushida MM, Cavalli FMG, Lee L, Rastegar N, Vu V, Sánchez-Osuna M, Coulombe-Huntington J, Kanshin E, Whetstone H, Durand M, Thibault P, Hart K, Mangos M, Veyhl J, Chen W, Tran N, Duong BC, Aman AM, Che X, Lan X, Whitley O, Zaslaver O, Barsyte-Lovejoy D, Richards LM, Restall I, Caudy A, Röst HL, Bonday ZQ, Bernstein M, Das S, Cusimano MD, Spears J, Bader GD, Pugh TJ, Tyers M, Lupien M, Haibe-Kains B, Artee Luchman H, Weiss S, Massirer KB, Prinos P, Arrowsmith CH, Dirks PB
Nat Commun 12(1):979 . doi: 10.1038/s41467-021-21204-5
Publication date: February 12, 2021
PMID: 33579912
Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Zhang M, Lei M, Qin S, Dong A, Yang A, Li Y, Loppnau P, Hughes TR, Min J, Liu Y
Biochim Biophys Acta Gene Regul Mech 194688 . doi: 10.1016/j.bbagrm.2021.194688
Publication date: February 5, 2021
PMID: 33556623
High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.
Chen J, Sivan U, Tan SL, Lippo L, De Angelis J, Labella R, Singh A, Chatzis A, Cheuk S, Medhghalchi M, Gil J, Hollander G, Marsden BD, Williams R, Ramasamy SK, Kusumbe AP
Sci Adv 7(6): . doi: 10.1126/sciadv.abd7819
Publication date: February 5, 2021
PMID: 33536212
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.
Ferreira de Freitas R, Liu Y, Szewczyk MM, Mehta N, Li F, McLeod D, Zepeda-Velázquez C, Dilworth D, Hanley RP, Gibson E, Brown PJ, Al-Awar R, James LI, Arrowsmith CH, Barsyte-Lovejoy D, Min J, Vedadi M, Schapira M, Allali-Hassani A
J Med Chem . doi: 10.1021/acs.jmedchem.0c01768
Publication date: February 1, 2021
PMID: 33522809

January 2021

Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics.
Santhakumar V, Sutherland M, Li A, Kaghad A, Panagopoulos D, Li F, Szewczyk M, Smil D, Scholten C, Bouché L, Stellfeld T, Arrowsmith CH, Barsyte D, Vedadi M, Hartung IV, Steuber H, Britton R
ChemMedChem . doi: 10.1002/cmdc.202100018
Publication date: January 29, 2021
PMID: 33513288
Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers.
Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GM, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP
Cancer Res . doi: 10.1158/0008-5472.CAN-20-3108
Publication date: January 28, 2021
PMID: 33509943
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
Berger BT, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, Schröder M, Neil R, Wang J, Navratilova I, Bomke J, Elkins JM, Müller S, Frech M, Wade RC, Knapp S
Cell Chem Biol . doi: 10.1016/j.chembiol.2021.01.003
Publication date: January 21, 2021
PMID: 33497606
Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain.
Bezerra GA, Holenstein A, Foster WR, Xie B, Hicks KG, Bürer C, Lutz S, Mukherjee A, Sarkar D, Bhattacharya D, Rutter J, Talukdar A, Brown PJ, Luo M, Shi L, Froese DS, Yue WW
Biochimie . doi: 10.1016/j.biochi.2021.01.007
Publication date: January 18, 2021
PMID: 33476699
Large-scale survey and database of high affinity ligands for peptide recognition modules.
Teyra J, Kelil A, Jain S, Helmy M, Jajodia R, Hooda Y, Gu J, D'Cruz AA, Nicholson SE, Min J, Sudol M, Kim PM, Bader GD, Sidhu SS
Mol Syst Biol 16(12):e9310 . doi: 10.15252/msb.20199310
Publication date: January 14, 2021
PMID: 33438817
BET inhibition disrupts transcription but retains enhancer-promoter contact.
Crump NT, Ballabio E, Godfrey L, Thorne R, Repapi E, Kerry J, Tapia M, Hua P, Lagerholm C, Filippakopoulos P, Davies JOJ, Milne TA
Nat Commun 12(1):223 . doi: 10.1038/s41467-020-20400-z
Publication date: January 11, 2021
PMID: 33431820
Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD
Cell Chem Biol . doi: 10.1016/j.chembiol.2020.12.013
Publication date: January 11, 2021
PMID: 33484635
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19.
Perveen S, Khalili Yazdi A, Devkota K, Li F, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Vedadi M
SLAS Discov 2472555220985040 . doi: 10.1177/2472555220985040
Publication date: January 10, 2021
PMID: 33423577
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, Vilar S, Wang J, Zuercher WJ, Willson TM, Drewry DH
Int J Mol Sci 22(2): . doi: 10.3390/ijms22020566
Publication date: January 8, 2021
PMID: 33429995
Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron.
Yan X, Wang X, Li Y, Zhou M, Li Y, Song L, Mi W, Min J, Dong C
Nat Chem Biol . doi: 10.1038/s41589-020-00703-4
Publication date: January 4, 2021
PMID: 33398170
The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting.
Wright ND, Collins P, Koekemoer L, Krojer T, Talon R, Nelson E, Ye M, Nowak R, Newman J, Ng JT, Mitrovich N, Wiggers H, von Delft F
Acta Crystallogr D Struct Biol 77(Pt 1):62-74 . doi: 10.1107/S2059798320014114
Publication date: January 1, 2021
PMID: 33404526
Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series.
Wang CB, Lorente-Macías Á, Wells C, Pickett JE, Picado A, Zuercher WJ, Axtman AD
RSC Med Chem 12(1):129-136 . doi: 10.1039/d0md00292e
Publication date: January 1, 2021
PMID: 34046605
2020

December 2020

How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine.
Wurzlbauer A, Rüben K, Gürdal E, Chaikuad A, Knapp S, Sippl W, Becker W, Bracher F
Molecules 25(24): . doi: 10.3390/molecules25245962
Publication date: December 16, 2020
PMID: 33339338

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