Publications | Structural Genomics Consortium

Identification of novel covalent ligands that disrupt Acetyl-Lysine binding to the SETDB1 tudor domain.

Ma J, Huang Y, Zheng T, Wang H, Li B, Liu S, Liu C, Chen X, Min J

Biochem Biophys Res Commun. 819:153815. doi: 10.1016/j.bbrc.2026.153815

Publication date: April 26, 2026

PMID: 42033939

Discovery of APO-50815, a potent WEE1 kinase inhibitor with exceptional efficacy against patient-derived colorectal cancer organoids.

Syphers JL, Wright JA, de Nys R, Silva TN, Vrbanac L, Barratt KR, Leeflang J, Hasan ST, Thomson SF, Kumar A, Krämer A, Lenz C, Gee YS, Chang A, Young S, Sloan EK, Knapp S, Worthley DL, Mukherjee S, Stockton K, Priebbenow DL, Woods SL, Baell JB

Eur J Med Chem. 312:118838. doi: 10.1016/j.ejmech.2026.118838

Publication date: April 25, 2026

PMID: 42030708

Comprehensive mass spectrometry screening-derived atlas of HDAC inhibitors reveals histone-specific acetylation changes.

Karki R, Vitorino FNL, Searfoss RM, Lempiäinen JK, Arrowsmith CH, Garcia BA

Cell Rep. 45(5):117289. doi: 10.1016/j.celrep.2026.117289

Publication date: April 24, 2026

PMID: 42030158

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.

Robertson KC, Amann SJ, Liu T, Funk AV, Wang X, Grishkovskaya I, Mehmood A, Tabor JR, Norris-Drouin JL, Arrowsmith CH, Collins JL, Miao Y, Emanuele MJ, Haselbach D, James LI, Brown NG

Nat Commun. doi: 10.1038/s41467-026-72235-9

Publication date: April 24, 2026

PMID: 42026065

Structure Merging Approach Leads to New Dual Potent and Selective USP25/USP28 Inhibitors.

Hernandez-Olmos V, Patzke JV, Stone CE, Nair RK, Weller K, Sauer F, Endres E, Jamai O, Rachor L, Warmutz CH, Schwalm MP, Mitrovic M, Grenier V, Ehrler JHM, Proschak A, Heering J, Sotriffer C, Mulder MPC, Knapp S, Kisker C, Proschak E

J Med Chem. doi: 10.1021/acs.jmedchem.5c03045

Publication date: April 22, 2026

PMID: 42017948

Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans.

Emond A, Laflamme C, Therrien M, Liao M, Maios C, Labarre A, Drapeau P, Parker JA

PLoS One. 21(4):e0346613. doi: 10.1371/journal.pone.0346613

Publication date: April 10, 2026

PMID: 41961863

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).

Tessier TM, Maitland MER, Kutera M, Dybas JM, St-Germain J, Arrowsmith CH, Barsyte-Lovejoy D, Zhang W, Raught B, Weitzman MD

Commun Biol. doi: 10.1038/s42003-026-09964-6

Publication date: April 10, 2026

PMID: 41957433

Rational discovery of therapeutic PAK1 allosteric activators.

He Y, Bae JSH, Nowak E, Outeiral C, Nissley DA, Tumber A, Berridge G, Salah E, Wang Y, He W, Zhang H, Chen T, Tusk S, Mathea S, Wang YJ, Grassam-Rowe A, Kukura P, Schofield CJ, O'Brien DP, Pierangelini A, Churchill GC, Lanyon-Hogg T, Ke Y, Xu C, Ye T, Watkins H, Ying L, Koschinski A, Solaro RJ, Tan X, Bolla JR, Wang X, Knapp S, Deane CM, Zaccolo M, Nowotny M, Lei M

Cell. doi: 10.1016/j.cell.2026.03.008

Publication date: April 2, 2026

PMID: 41923641

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.

Param NJ, Arceci E, Fiorentino F, Pignata L, Torre D, Gutiérrez-Trejo N, Fong JY, Goy PA, Han BY, Lambona C, Di Bello E, Castiello C, Barone M, Schwarz M, Arrowsmith C, Ito K, Scherle P, Wee DKB, Ndoye S, Tabaglio T, Jeyasekharan AD, Lakshmanan M, Cirilli R, Habisch H, Madl T, Mattevi A, Valente S, Mai A, Guccione E

Sci Adv. 12(13):eaea4059. doi: 10.1126/sciadv.aea4059

Publication date: March 27, 2026

PMID: 41894488

Dual-site phosphorylation of SLX4 stabilizes the SLX4-MUS81 interface to promote mitotic SMX assembly and genome protection.

Payliss BJ, Yun HY, Doshi S, Lemak A, Tse YWE, Aprosoff CM, Houliston S, Arrowsmith CH, Wyatt HDM

Nucleic Acids Res. doi: 10.1093/nar/gkag195

Publication date: March 17, 2026

PMID: 41841343

High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.

Fanti R, Wolf E, Ikenoue T, Deme JC, Balakrishnan S, Keith BA, Alteen MG, Chandrasekaran R, Yadav M, Bhajiawala R, Ackloo S, Feng J, Pouladi MA, Edwards AM, Wilson DJ, Lea SM, Suga H, Harding RJ

Proc Natl Acad Sci U S A. 123(12):e2520462123. doi: 10.1073/pnas.2520462123

Publication date: March 16, 2026

PMID: 41838909

Screening assay to monitor mono-ADP-ribosylhydrolase activity of viral macrodomains in cells.

Knapp S, Weber V, Verheirstraeten M, Sabcheva A, Wright T, Herkens L, Hauser L, Hirschen L, Golzmann A, Lippok B, Krieg S, Ferraris D, Knapp S, Ladurner AG, Rossetti G, Lüscher B, Korn P

Commun Biol. 9(1):. doi: 10.1038/s42003-026-09832-3

Publication date: March 13, 2026

PMID: 41820535

Evaluation of ensilication technology for ambient DNA preservation.

Blas M, Yu C, Aghababazadeh FA, Hoelscher V, Volz M, Morales L, Jarolik K, Dong X, Dobin S, Rantasalo T, Hirvonen T, Pursiheimo JP, Laine N, Homer N, Chamoun C, Pierce W, Organick L, Fehr A, Becich M, Banal JL, Youens K, Tamminen M, Haibe-Kains B, Bedard P

NAR Mol Med. 3(1):ugag011. doi: 10.1093/narmme/ugag011

Publication date: March 9, 2026

PMID: 41797988

Structure-Based Discovery of Selective Vaccinia-Related Kinase 1 Inhibitors and Fluorogenic Active-Site Probes.

Crowley-Dolen EK, Borges RJ, Charifson PS, Payne NC, de Oliveira RG, Cunha MR, Mazitschek R, Massirer KB, Mitchison TJ

J Biol Chem. 111355. doi: 10.1016/j.jbc.2026.111355

Publication date: March 9, 2026

PMID: 41796804

Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5.

Wang X, Wang F, Kong D, Uredi D, Li F, Li F, Rayadurgam J, Li H, Wolf E, Chan UH, Chau I, Zeng H, Perez JG, Wilson DJ, Bashore FM, Wang X, Halabelian L, Frankowski KJ, Kireev D, Axtman AD

Eur J Med Chem. 309:118724. doi: 10.1016/j.ejmech.2026.118724

Publication date: March 8, 2026

PMID: 41795418

USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion.

Collotta G, Gatti M, Ungureanu IM, van Ackeren V, Rannou E, Vivalda F, Gomez Vieito D, Fishwick KM, von Aesch C, Porro A, Ungerleider K, Heidari A, Guérois R, Harding RJ, Bischof S, Balmus G, Sartori AA

Nat Commun. doi: 10.1038/s41467-026-70051-9

Publication date: March 6, 2026

PMID: 41786746

Novel monoclonal antibodies against the C-terminal HEAT domain of huntingtin.

Park YN, Fanti R, Sadeghi S, Chandrasekaran R, Edwards AM, Harding RJ, Houston DW

J Huntingtons Dis. 18796397261426634. doi: 10.1177/18796397261426634

Publication date: March 5, 2026

PMID: 41784089

Evaluation of non-canonical p53 functions in DNA replication and recombination for variant classification.

Jansche R, Heitmeir B, Faust U, Pospiech H, Sutter C, Albig C, Hennig F, Janni W, Schmutzler R, Hauke J, Joerger AC, Wiesmüller L

Cell Death Dis. doi: 10.1038/s41419-026-08463-0

Publication date: March 1, 2026

PMID: 41764184

Kinase Chemical Probes and Beyond

Claudia Tredup, Susanne Müller

Kinases Phosphatases. 1.

Publication date: March 1, 2026

PMID: 41797000

Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt.

Mavridi D, Funk JS, Balourdas DI, Krämer A, Khan Tareque R, Timofeev O, Spencer J, Stiewe T, Joerger AC

Cell Death Dis. doi: 10.1038/s41419-026-08492-9

Publication date: February 27, 2026

PMID: 41748563

The N-Myc MB0-MBI region interacts specifically and dynamically with the N-lobe of Aurora kinase A.

Hultman J, Morad V, Tanner E, Kenney TMG, Pietras Z, Khare LP, Derbyshire D, Resetca D, Arrowsmith CH, Aili D, Ekström S, Penn LZ, Wallner B, Ahlner A, Sunnerhagen M

Nat Commun. 17(1):. doi: 10.1038/s41467-026-69725-1

Publication date: February 25, 2026

PMID: 41735282

Anti-MDA5 monoclonal antibodies from patients with dermatomyositis - B cell characteristics and differential targeting of the helicase domains.

Van Gompel E, Galešić M, Delaroque N, Kern K, Stålesen R, Notarnicola A, Demirdal D, Hansson M, van Vollenhoven A, Wigren E, Gräslund S, Szardenings M, Malmström V, Lundberg IE, Horuluoglu B, Grönwall C, Chemin K, Joshua V

J Autoimmun. 159:103536. doi: 10.1016/j.jaut.2026.103536

Publication date: February 20, 2026

PMID: 41719605

Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding Domain.

Silva M, Mann M, Mirabi B, Szewczyk MM, Loup J, Dupeux A, Chandrasekaran R, Bajohr J, Arrowsmith C, Schapira M, Lautens M, Barsyte-Lovejoy D, Harding RJ, Santhakumar V

J Med Chem. doi: 10.1021/acs.jmedchem.5c02976

Publication date: February 20, 2026

PMID: 41718545

Synthesis and Characterization of ULK1/2 Kinase Inhibitors That Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer.

Layng FIAL, Ren H, Bakas NA, Panickar DR, Lambert LJ, Celeridad M, Wu J, De Backer L, Chandrachud P, Limpert AS, Vamos M, Chaikuad A, Verdugo BB, Hagan PM, Brun SN, Tautz L, Knapp S, Shaw RJ, Salvesen GS, Sheffler DJ, Cosford NDP

ACS Chem Biol. doi: 10.1021/acschembio.5c00711

Publication date: February 12, 2026

PMID: 41674365

Cellular Context Influences Kinase Inhibitor Selectivity.

Binder MJ, Bashore FM, Dunn Hoffman KK, Damgaard C, Slater M, Drewry DH, Robers MB, Axtman AD

J Med Chem. doi: 10.1021/acs.jmedchem.5c02916

Publication date: February 7, 2026

PMID: 41651452

Idler Compounds: A Simple Protocol for Openly Sharing Fridge Contents for Cross-Screening.

Isaksson R, Carter EM, Hind CK, Sutton JM, Rudgyard H, Roberts AH, Moon CW, Wang Y, Codony S, Martínez AL, Bacon J, Todd MH

J Med Chem. doi: 10.1021/acs.jmedchem.5c02354

Publication date: January 28, 2026

PMID: 41603458

A disease-causing Isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response.

Gao H, Tennakoon R, Araújo FP, Miller JM, Nyandwi SP, Shi Q, Padilla-Martínez JP, Peng H, Cui H

J Biol Chem. 111196. doi: 10.1016/j.jbc.2026.111196

Publication date: January 26, 2026

PMID: 41581867

Development of a Chemical Probe to Enable Characterization of the Casein Kinase 1γ Subfamily.

Capener JL, Kramer TW, Bashore FM, Flory E, Li F, Strang BL, Axtman AD

J Med Chem. doi: 10.1021/acs.jmedchem.5c02609

Publication date: January 26, 2026

PMID: 41587072

Glioblastoma stem cells show transcriptionally correlated spatial organization.

Ayyadhury S, Sachamitr P, Kushida MM, Park NI, Coutinho FJ, Whitley O, Prinos P, Arrowsmith CH, Dirks PB, Pugh TJ, Bader GD

Commun Biol. doi: 10.1038/s42003-026-09566-2

Publication date: January 24, 2026

PMID: 41577992

Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery.

Mitrović M, Greco FA, García YC, Lučić A, Hoffmann L, Chander R, Schönfeld J, Liebisch N, Sivashanmugam SA, Schwalm MP, Egner M, Lewandowski M, Merk D, Morasch V, Wolf E, Müller S, Hanke T, Proschak E, Hiesinger K, Knapp S

J Med Chem. doi: 10.1021/acs.jmedchem.5c02543

Publication date: January 23, 2026

PMID: 41575171

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M

J Chem Inf Model. doi: 10.1021/acs.jcim.5c02441

Publication date: January 22, 2026

PMID: 41565251

S-adenosylhomocysteine analogs selectively suppress pan-coronavirus replication by inhibition of nsp14 methyltransferase.

Rosas-Lemus M, Athe S, Minasov G, Pattie JA, Brunzelle JS, Chau I, Li F, Vedadi M, Ma H, Ramanathan A, Becker ME, Hope TJ, Abdelkarim H, Grudzien P, Gaponenko V, Montgomery JE, Moellering RE, Rawal VH, Satchell KJF

ACS Med Chem Lett. doi: 10.1021/acsmedchemlett.5c00510

Publication date: January 22, 2026

PMID: 41568342

Structural basis for sequence-specific DNA recognition by a group IId WRKY transcription factor GhWRKY17 in cotton.

Xiao Q, Wang Y, Shang X, Chen Y, Zhang M, Zhou Y, Huang X, Qin S, Min J, Xu G, Liu Y

Biochem J. 483(2):. doi: 10.1042/BCJ20250191

Publication date: January 22, 2026

PMID: 41569870

A Hanks-type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation.

Lima LDP, Sriranganadane D, da Silva DL, Drebes Dörr NC, Mello EBS, Dos Reis CV, Lourenço RF, Santos JFTDS, Salmazo A, Miranda BW, Massirer KB, Couñago RM, Alvarez-Martinez CE

FEBS J. doi: 10.1111/febs.70384

Publication date: January 9, 2026

PMID: 41506723

Advances in BRET probes for intracellular target engagement studies.

Capener JL, Schwalm MP, Vasta JD, Michaud A, Teske KA, Marsiglia WM, Huber KVM, Dar AC, Knapp S, Axtman AD, Robers MB

Nat Chem Biol. doi: 10.1038/s41589-025-02103-y

Publication date: January 7, 2026

PMID: 41495225

Discovery of predictive biomarkers for cancer therapy through computational approaches.

Wang X, Nguyen J, Nader K, Miihkinen M, Wall P, Singhal A, Bedard PL, Ideker T, Aittokallio T, Haibe-Kains B

Nat Rev Clin Oncol. doi: 10.1038/s41571-025-01109-8

Publication date: January 7, 2026

PMID: 41495240

PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.

Yang T, Huhe H, Williams SP, Kaur S, Ay YA, Davis-Gilbert ZW, Cary GA, Paisie C, Butler RR 3rd, Wiley J, Betarbet R, Fu H, Duong D, Seyfried NT, Leal K, Carter GW, Edwards A, Levey AI, Capener JL, Drewry DH, Hossain MA, Oh HJ, Axtman AD, Sukoff Rizzo SJ, Longo FM

Alzheimers Dement. 21(12):e71033. doi: 10.1002/alz.71033

Publication date: December 26, 2025

PMID: 41451871

Basic Science and Pathogenesis.

Ayoubi R, Edwards AM, McPherson PS, Laflamme C

Alzheimers Dement. 21 Suppl 1:e100417. doi: 10.1002/alz70855_100417

Publication date: December 24, 2025

PMID: 41435866

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities.

Taherian F, Mabanglo MF, Hajian T, Tucker S, Kalinic E, Perveen S, Aman A, Vedadi M

Protein Sci. 35(1):e70428. doi: 10.1002/pro.70428

Publication date: December 23, 2025

PMID: 41432309

Enantioselective protein affinity selection mass spectrometry (E-ASMS).

Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Green SR, Silva M, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Müller S, Knapp S, Owen DR, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, Halabelian L

Nat Commun. doi: 10.1038/s41467-025-67403-2

Publication date: December 18, 2025

PMID: 41407727

Enhancing Clinical Cancer Research Through Sharing of Data and Biospecimens.

Wildiers H, Adam V, O'Reilly S, Van Cauwenberge J, Arahmani A, Arteaga CL, Bedard PL, Bliss J, Boussis P, Brain E, Buyse M, Caballero C, Cameron D, Cardoso F, Carrasco E, Casas A, Chua B, Curigliano G, DeMichele A, Esserman L, Floris G, Goetz MP, Goulioti T, Haibe-Kains B, Hodgdon C, Ignatiadis M, Kok M, Lacombe D, Linderholm B, Loi S, Lord CJ, MacKenzie M, Maues J, Meheus L, Needham J, Neven P, Parsons H, Piccart M, Pusztai L, Razis E, Saji S, Schumacher-Wulf E, Sonke GS, Spanic T, Tannock IF, Tutt A, Urruticoechea A, van 't Veer L, Vaz-Luis I, Werutsky G, Yee D, Zaman K, Desmedt C

JAMA Oncol. doi: 10.1001/jamaoncol.2025.5376

Publication date: December 18, 2025

PMID: 41410930

Overcoming Ligand Discovery Challenges: Developing Peptide-Based Tracers for SPSB2.

Lenz C, Elson L, Dopfer J, Farges F, Krämer A, Löhr F, Müller S, Guéret SM, Waldmann H, Dötsch V, Saxena K, Knapp S

ACS Chem Biol. doi: 10.1021/acschembio.5c00702

Publication date: December 8, 2025

PMID: 41358868

Targeting bacterial kinases as a strategy to counteract antibiotic resistance.

Buffa V, Kowalewski J, Qi G, Deutscher R, Cica M, Richardoz M, Tomaszczyk M, Krämer A, Knapp S, Dunyach-Remy C, Rox K, Guichou JF, Lionne C, Hausch F

Commun Chem. 8(1):390. doi: 10.1038/s42004-025-01794-7

Publication date: December 5, 2025

PMID: 41345223

A guide to selecting high-performing antibodies for Heterogeneous nuclear ribonucleoproteins A2/B1(hnRNP A2/B1) (UniProt ID: P22626) for use in western blot, immunoprecipitation, and immunofluorescence.

Moleón VR, Ayoubi R, Alende C, Fothouhi M, Ryan J, Bolívar SG, Worrall D, Durcan TM, Brown CM, Francis V, McPherson PS, Laflamme C

F1000Res. 14:1158. doi: 10.12688/f1000research.170886.1

Publication date: December 4, 2025

PMID: 41341144

Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity.

Oh HJ, Sears JD, Ramalingam BM, Saleem RSZ, Davis-Gilbert ZW, Hossain MA, Moorman SR, Ohja D, Martinez SA, Burdick JE, Couñago RM, Moorman NJ, Heise MT, Todd MH, Willson TM

RSC Med Chem. doi: 10.1039/d5md00772k

Publication date: November 26, 2025

PMID: 41292551

Water Networks as Hydrophobic Recognition Motifs in Proteins.

Piticchio SG, Martínez-Cartró M, Scaffidi S, Rodríguez-Arévalo S, Bagán A, Sánchez-Arfelis A, Picaud S, Krojer T, Filippakopoulos P, von Delft F, Escolano C, Galdeano C, Barril X

Angew Chem Int Ed Engl. e21138. doi: 10.1002/anie.202521138

Publication date: November 21, 2025

PMID: 41267475

Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability.

Kröll-Hermi A, Stoetzel C, Etard C, Halabelian L, Schaefer E, Scheidecker S, Kahrizi K, Payman J, Geoffroy V, Prasad M, Obringer C, Ruch L, Girard A, Zeng H, Li F, Plassard D, Keime C, Mattioli F, Feger C, Piton A, Fujita A, Matsumoto N, Castro MAA, Ae KC, Ruaud L, Levy J, Dozières B, Tabet AC, Wentzensen IM, Santiago-Sim T, Yusupov R, Tveten K, Smeland MF, Alkhunaizi E, Cowing G, Li C, Wortmann SB, Feichtinger RG, Mayr JA, Gonorazky H, Jing G, Wang X, Wang J, Bierhals T, Grinstein L, Herget T, Ruiz A, Gabau E, Kampmeier A, Kassel O, Kuechler A, Platzer K, Jamra RA, Woerner A, Idleburg M, Kircher SG, Laccone F, Golob B, Peterlin B, Čuturilo G, Tasic V, Kolvenbach CM, Hildebrandt F, Ramos LLP, Kok F, Buck CB, van de Laar IMBH, de Man SA, Taşdelen E, Sezer A, Büke A, Yavuz Z, Çomoğlu SS, Costin C, Tran Mau Them F, Lacaze E, Courtin T, Héron D, Keren B, Whalen S, Roume J, Yang Y, Hoffer MJV, van Haeringen A, Najmabadi H, Arrowsmith CH, Strähle U, Dollfus H, Muller J

Am J Hum Genet. doi: 10.1016/j.ajhg.2025.10.014

Publication date: November 20, 2025

PMID: 41260215

BRSK2 plays a role in autophagy and cancer cell growth and survival under nutrient deprivation stress via the PIK3C3 pathway.

Maiti A, Axtman AD, Wu R, Redman LJB, Takabe K, Stablewski AB, Yan L, Ciesielski MJ, Zhang J, Evans SS, Kalinski P, Hait NC

Sci Rep. 15(1):40651. doi: 10.1038/s41598-025-24354-4

Publication date: November 19, 2025

PMID: 41258112

Un-LOK-ing a New Approach for Conformational Selective Targeting of STK10 (LOK).

Dettenhöfer M, Tandara LN, Amrhein JA, Kurz CG, Schwalm MP, Mensing TE, Wahl LM, Krämer A, Gerninghaus J, Lenz C, Elson L, Berger BT, Schröder M, Saxena K, Müller S, Knapp S, Greco FA, Hanke T

ACS Med Chem Lett. 16(11):2086-2096. doi: 10.1021/acsmedchemlett.5c00479

Publication date: November 19, 2025

PMID: 41256983

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1.

Hank EC, D'Arcy-Evans ND, Scaletti ER, Benítez-Buelga C, Wallner O, Ortis F, Zhou K, Meng L, Del Prado A, Calvo P, Almlöf I, Wiita E, Nierlin K, Košenina S, Krämer A, Eddershaw A, Kehler M, Long M, Jemth AS, Dawson H, Stewart J, Dickey A, Astorga ME, Varga M, Homan EJ, Scobie M, Knapp S, Sastre L, Stenmark P, de Vega M, Helleday T, Michel M

RSC Chem Biol. doi: 10.1039/d4cb00323c

Publication date: November 6, 2025

PMID: 41195166