Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8. Read more about Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. Read more about Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.
Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening. Read more about Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening.
Predictions of ligand selectivity from absolute binding free energy calculations. Read more about Predictions of ligand selectivity from absolute binding free energy calculations.
Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation. Read more about Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Read more about Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Read more about Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. Read more about Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma. Read more about Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.
Chemical Probes Targeting Epigenetic Proteins: Applications Beyond Oncology. Read more about Chemical Probes Targeting Epigenetic Proteins: Applications Beyond Oncology.
