Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3- b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity. Read more about Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3- b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Read more about C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Structural and functional consequences of the STAT5BN642H driver mutation. Read more about Structural and functional consequences of the STAT5BN642H driver mutation.
Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 deficiency. Read more about Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 deficiency.
A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin. Read more about A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.
Insights into the full-length SRPK2 structure and its hydrodynamic behavior. Read more about Insights into the full-length SRPK2 structure and its hydrodynamic behavior.
Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition. Read more about Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Read more about Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Streamlining the production of proteins for structural biology. Read more about Streamlining the production of proteins for structural biology.
A genetics-led approach defines the drug target landscape of 30 immune-related traits. Read more about A genetics-led approach defines the drug target landscape of 30 immune-related traits.
