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Chemical Probes for Protein Arginine Methyltransferases.

  • Read more about Chemical Probes for Protein Arginine Methyltransferases.

Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor.

  • Read more about Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor.

Discovery of a chemical probe for PRDM9.

  • Read more about Discovery of a chemical probe for PRDM9.

Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.

  • Read more about Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.

Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro.

  • Read more about Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro.

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.

  • Read more about The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.

  • Read more about Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.

ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.

  • Read more about ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.

15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.

  • Read more about 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.

Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells.

  • Read more about Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells.

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