15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism. Read more about 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Read more about Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).
Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3- b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity. Read more about Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3- b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Read more about C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Structural and functional consequences of the STAT5BN642H driver mutation. Read more about Structural and functional consequences of the STAT5BN642H driver mutation.
Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 deficiency. Read more about Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 deficiency.
A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin. Read more about A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.
Insights into the full-length SRPK2 structure and its hydrodynamic behavior. Read more about Insights into the full-length SRPK2 structure and its hydrodynamic behavior.
Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition. Read more about Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Read more about Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
