Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs. Read more about Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism. Read more about Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.
Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas. Read more about Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.
HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Read more about HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells.
Open innovation in neuroscience research and drug discovery. Read more about Open innovation in neuroscience research and drug discovery.
A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5. Read more about A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K. Read more about SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design. Read more about Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design.
Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex. Read more about Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.
The RESOLUTE consortium: unlocking SLC transporters for drug discovery. Read more about The RESOLUTE consortium: unlocking SLC transporters for drug discovery.
