The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions. Read more about The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Read more about Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.
Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase. Read more about Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase.
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition. Read more about E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.
Targeting an EGFR water network using novel 4-anilinoquin(az)olines inhibitors for chordoma. Read more about Targeting an EGFR water network using novel 4-anilinoquin(az)olines inhibitors for chordoma.
Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain. Read more about Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain.
Target highlights in CASP13: experimental target structures through the eyes of their authors. Read more about Target highlights in CASP13: experimental target structures through the eyes of their authors.
Open laboratory notebooks: good for science, good for society, good for scientists. Read more about Open laboratory notebooks: good for science, good for society, good for scientists.
Modular Synthesis of Di- and Tri-substituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors. Read more about Modular Synthesis of Di- and Tri-substituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.
The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency. Read more about The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency.
