E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition. Read more about E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.
Targeting an EGFR water network using novel 4-anilinoquin(az)olines inhibitors for chordoma. Read more about Targeting an EGFR water network using novel 4-anilinoquin(az)olines inhibitors for chordoma.
Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain. Read more about Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain.
Target highlights in CASP13: experimental target structures through the eyes of their authors. Read more about Target highlights in CASP13: experimental target structures through the eyes of their authors.
Open laboratory notebooks: good for science, good for society, good for scientists. Read more about Open laboratory notebooks: good for science, good for society, good for scientists.
Modular Synthesis of Di- and Tri-substituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors. Read more about Modular Synthesis of Di- and Tri-substituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.
The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency. Read more about The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency.
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Read more about Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Read more about The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA. Read more about LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.
