Discovery of allosteric binding sites by crystallographic fragment screening. Read more about Discovery of allosteric binding sites by crystallographic fragment screening.
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms. Read more about Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Read more about Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. Read more about Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system. Read more about Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system.
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. Read more about A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. Read more about Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.
A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks. Read more about A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks.
BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy. Read more about BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy.
