Bioisosteric Replacement of Arylamide-linked Spine Residues by N-Acylhydrazones and Selenophenes as Design Strategy to Novel Dibenzosuberone Derivatives as Type I½ p38 MAP Kinase Inhibitors. Read more about Bioisosteric Replacement of Arylamide-linked Spine Residues by N-Acylhydrazones and Selenophenes as Design Strategy to Novel Dibenzosuberone Derivatives as Type I½ p38 MAP Kinase Inhibitors.
Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases. Read more about Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases.
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. Read more about STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Read more about Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Quantifying CDK inhibitor selectivity in live cells. Read more about Quantifying CDK inhibitor selectivity in live cells.
Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release. Read more about Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release.
A lower X-gate in TASK channels traps inhibitors within the vestibule. Read more about A lower X-gate in TASK channels traps inhibitors within the vestibule.
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Read more about Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.
Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Read more about Recognition of nonproline N-terminal residues by the Pro/N-degron pathway.
Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution. Read more about Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution.
