Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Read more about Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Read more about Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers. Read more about Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers.
Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics. Read more about Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics.
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. Read more about Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.
Substrate reduction therapy for inborn errors of metabolism. Read more about Substrate reduction therapy for inborn errors of metabolism.
High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging. Read more about High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.
Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. Read more about Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells. Read more about Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells.
A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation. Read more about A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation.
