Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. Read more about Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. Read more about Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern. Read more about Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern.
Controlling the Covalent Reactivity of a Kinase Inhibitor with Light. Read more about Controlling the Covalent Reactivity of a Kinase Inhibitor with Light.
Crowdsourced mapping of unexplored target space of kinase inhibitors. Read more about Crowdsourced mapping of unexplored target space of kinase inhibitors.
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. Read more about Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Read more about Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Read more about Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Read more about Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. Read more about Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
