Chemical biology and pharmacology of histone lysine methylation inhibitors. Read more about Chemical biology and pharmacology of histone lysine methylation inhibitors.
Human Diacylglycerol Kinase ε N-Terminal Segment Regulates the Phosphatidylinositol Cycle, Controlling the Rate but Not the Acyl Chain Composition of Its Lipid Intermediates. Read more about Human Diacylglycerol Kinase ε N-Terminal Segment Regulates the Phosphatidylinositol Cycle, Controlling the Rate but Not the Acyl Chain Composition of Its Lipid Intermediates.
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding. Read more about CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding.
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function. Read more about Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.
A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria. Read more about A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria.
Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors. Read more about Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors.
Binding adaptation of GS-441524 diversifies macro domains and downregulate SARS-CoV-2 de-MARylation capacity. Read more about Binding adaptation of GS-441524 diversifies macro domains and downregulate SARS-CoV-2 de-MARylation capacity.
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Read more about Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3-d]pyrimidine Core. Read more about A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3-d]pyrimidine Core.
Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro. Read more about Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.
