PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. Read more about PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.
Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Read more about Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
Structural basis for Gemin5 decamer-mediated mRNA binding. Read more about Structural basis for Gemin5 decamer-mediated mRNA binding.
Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes. Read more about Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes.
Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains. Read more about Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains.
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1. Read more about CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1.
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses. Read more about Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.
A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Read more about A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Read more about Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands. Read more about Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
