A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria. Read more about A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria.
Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors. Read more about Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors.
Binding adaptation of GS-441524 diversifies macro domains and downregulate SARS-CoV-2 de-MARylation capacity. Read more about Binding adaptation of GS-441524 diversifies macro domains and downregulate SARS-CoV-2 de-MARylation capacity.
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Read more about Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3-d]pyrimidine Core. Read more about A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3-d]pyrimidine Core.
Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro. Read more about Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.
Compilation and evaluation of a fatty acid mimetics screening library. Read more about Compilation and evaluation of a fatty acid mimetics screening library.
Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors. Read more about Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors.
Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells. Read more about Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells.
PROTAC degraders as chemical probes for studying target biology and target validation. Read more about PROTAC degraders as chemical probes for studying target biology and target validation.
