Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Read more about Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
Structural basis for Gemin5 decamer-mediated mRNA binding. Read more about Structural basis for Gemin5 decamer-mediated mRNA binding.
Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes. Read more about Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes.
Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains. Read more about Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains.
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1. Read more about CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1.
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses. Read more about Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.
A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Read more about A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Read more about Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands. Read more about Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
ChemBioPort: an online portal to navigate the structure, function and chemical inhibition of the human proteome. Read more about ChemBioPort: an online portal to navigate the structure, function and chemical inhibition of the human proteome.
