Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Read more about Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors.
RAS and PP2A activities converge on epigenetic gene regulation. Read more about RAS and PP2A activities converge on epigenetic gene regulation.
Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators. Read more about Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.
Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor. Read more about Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor.
Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells. Read more about Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells.
Reference compounds for characterizing cellular injury in high-content cellular morphology assays. Read more about Reference compounds for characterizing cellular injury in high-content cellular morphology assays.
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum. Read more about Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.
Discovery of Nanomolar DCAF1 Small Molecule Ligands. Read more about Discovery of Nanomolar DCAF1 Small Molecule Ligands.
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. Read more about Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. Read more about A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi.
