Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. Read more about Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.
Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons. Read more about Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons.
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. Read more about Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
Cascade Synthesis of Kinase-Privileged 3-Aminoindazoles via Intramolecular N-N Bond Formation. Read more about Cascade Synthesis of Kinase-Privileged 3-Aminoindazoles via Intramolecular N-N Bond Formation.
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. Read more about LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.
Image-Based Annotation of Chemogenomic Libraries for Phenotypic Screening. Read more about Image-Based Annotation of Chemogenomic Libraries for Phenotypic Screening.
Target 2035 - update on the quest for a probe for every protein. Read more about Target 2035 - update on the quest for a probe for every protein.
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2. Read more about Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome. Read more about Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome.
The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase. Read more about The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
