Matthieu Schapira

MaRS Centre, South Tower, 101 College St., Suite 700, Toronto, ON, M5G 1L7, Canada

Affiliations

Biography

Matthieu Schapira, PhD is a Professor in the Department of Pharmacology and Toxicology, UofT, and is the head of computational chemistry, protein bioinformatics, and data management at the SGC-Toronto. He leads the CACHE initiative for benchmarking computational ‘hit finding’. Dr. Schapira is a recognized authority in the structural chemistry of drug target classes such as chromatin regulators, ubiquitylation pathways and WDR proteins, and has created popular online informatics resources for these targets such as Chromohub, Ubihub and ChemBioPort. He is interested in novel strategies to expand and ML tools to exploit the accessible chemistry space. His trainees have gone on to become important innovators in AI-driven drug discovery at Toronto-born biotechs such as Atomwise and Cyclica.

SGC Open Chemistry Networks: Terms of Use and Participation

  1. Introduction

    The mission of the Structural Genomics Consortium (“SGC”) Open Chemistry Networks platform (“Open Chem Networks”) is to bring together the knowledge, expertise, and resources of a large, distributed network of like-minded chemists from around the world to help SGC create new, open access Chemical Probes (defined below) against novel protein targets and to make them openly available to the research community without restrictions on use in order to catalyze research in new areas of human disease biology and drug discovery (the “

Frequently Asked Questions

Who is involved in OCN?

This is an SGC initiative, and all SGC sites are contributing biochemistry and cell biology. There are synthetic chemistry contributors throughout the SGC, and the Head of Open Chemistry Networks is Professor Mat Todd at University College London.

What is open-source science?

Funding

SGC is a UK-registered charity that supports seven open science research sites worldwide. 

Current SGC Pharma Members provide funding and collaborate on scientific research without retaining intellectual property rights or advanced knowledge of outputs.

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Equity, Diversity and Inclusion

The Structural Genomics Consortium (SGC) is strongly committed to equity, diversity, and inclusion. We strive to create an environment that welcomes individuals from all groups, countries, organizations and institutions in our research community. With the mission of creating global access to drug discovery through open science, SGC also endeavours to further the diversity of ideas and approaches in the workplace.

Donated chemical probes

In this unique project, pharmaceutical companies and leading academic laboratories make their innovative high-quality chemical probes available to the research community through the SGC. These donated probes complement the probes generated by the SGC and its collaborators. All compounds accepted into the donated probes program meet the chemical probe quality criteria and have been evaluated by an internal as well as an external expert committee. Moreover, several probes are suitable for in vivo use. Control compounds are also provided and profiled. 

Chemical Probes

SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. SGC-developed probes are complemented by a growing set of donated high-quality chemical probes developed in industry and non-SGC laboratories. These are also available for unencumbered use.

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