Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module. Read more about Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module.
Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases. Read more about Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.
Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases. Read more about Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases.
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Read more about A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma. Read more about Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma.
Strategy to Target the Substrate Binding site of SET Domain Protein Methyltransferases. Read more about Strategy to Target the Substrate Binding site of SET Domain Protein Methyltransferases.
A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. Read more about A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency.
Insight into S-adenosyl-L-methionine biosynthesis from crystal structures of human methionine adenosyltransferase catalytic and regulatory subunits. Read more about Insight into S-adenosyl-L-methionine biosynthesis from crystal structures of human methionine adenosyltransferase catalytic and regulatory subunits.
Bromo-deaza-SAH: A potent and selective DOT1L inhibitor. Read more about Bromo-deaza-SAH: A potent and selective DOT1L inhibitor.
