Selective Bisubstrate Inhibitors with Sub-nanomolar Affinity for Protein Kinase Pim-1. Read more about Selective Bisubstrate Inhibitors with Sub-nanomolar Affinity for Protein Kinase Pim-1.
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP. Read more about Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.
A New Class of Small Molecule Inhibitor of BMP Signaling. Read more about A New Class of Small Molecule Inhibitor of BMP Signaling.
X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor. Read more about X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor.
Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition. Read more about Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition.
Homozygous mutations in a predicted endonuclease cause Congenital Dyserythropoietic Anemia Type I. Read more about Homozygous mutations in a predicted endonuclease cause Congenital Dyserythropoietic Anemia Type I.
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Read more about Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Quantitative Analysis of Histone Demethylase Probes Using Fluorescence Polarization. Read more about Quantitative Analysis of Histone Demethylase Probes Using Fluorescence Polarization.
Effect of single amino Acid substitution observed in cancer on pim-1 kinase thermodynamic stability and structure. Read more about Effect of single amino Acid substitution observed in cancer on pim-1 kinase thermodynamic stability and structure.
Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations. Read more about Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations.
