![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
Chemical Probes
Chemical Probes
Potent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories.
SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. To acquire a sample, follow the links on the webpage of your desired chemical probe. You can sort the table by clicking the column headers.
The SGC probes set is complemented by the donated probe set
Name | Structures | Protein family | Specific Targets |
Control![]() |
In Vivo Activity* | Added |
---|---|---|---|---|---|---|
Bromosporine (BSP) (tool compound) |
![]() |
Bromodomains | pan-Bromodomain | No | 01/13 | |
BI-4394 |
![]() |
Protease | MMP13 | BI-4395 | Yes | 11/18 |
BI-2540 |
![]() |
Reverse transcriptase | HIV NNRT | BI-2439 | Yes | 11/20 |
MLi-2 |
![]() |
Kinase | LRRK2 | MLi-2-NC | Yes | 05/19 |
PFI-653 |
![]() |
Hydrolase | VNN1 | PFI-653-N | Yes | 09/21 |
PF-05105679 |
![]() |
Ion channel | TRPM8 | PF-05257137 | Yes | 05/18 |
ABT-100 |
![]() |
Transferase | FNTB | A-108 | Yes | 05/18 |
NVS-MALT1 |
![]() |
Protease | MALT1 | NVS-MALT1-C | Yes | 02/20 |
PFI-4 |
![]() |
Bromodomains | BRPF1 | No | 12/14 | |
BAY-784 |
![]() |
GPCR | GNRHR | BAY-786 | Yes | 11/18 |
GSK620 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | Yes | 02/21 | |
BI 665915 |
![]() |
Lipoxygenase | ALOX5AP | BI-0153 | Yes | 05/18 |
MSD-M1PAM |
![]() |
GPCR | CHRM1 | MSD-M1PAM-NC | Yes | 08/19 |
TP-050 |
![]() |
Ion channel | GRIN2A | TP-050n | Yes | 09/22 |
SR-318 |
![]() |
Kinase | MAPK14 | SR-321 | No | 01/20 |
JNJ-9350 |
![]() |
Oxidase | SMOX | JNJ-4545 | Yes | 09/22 |
GSK-LSD1 |
![]() |
Lysine Demethylase | KDM1A/LSD1 | No | 03/14 | |
BAY-678 |
![]() |
Protease | ELANE | BAY-677 | Yes | 05/18 |
BAY-069 |
![]() |
Amino acid transaminase | BCAT1, BCAT2 | BAY-771 | Yes | 09/20 |
T3-CLK |
![]() |
Kinase | CLK1, CLK2, CLK3, CLK4 | T3-CLK-N | No | 04/19 |
JNJ-42396302 |
![]() |
Phosphodiesterase | PDE10A | JNJ-40573663 | Yes | 09/21 |
BI-1935 |
![]() |
Hydrolase | EPHX2 | BI-2049 | Yes | 05/18 |
BAY-386 |
![]() |
GPCR | F2R | BAY-448 | Yes | 05/18 |
FS-694 |
![]() |
Kinase | MAPK14 | FM-743 | No | 01/20 |
A-366 |
![]() |
Methyltransferase | EHMT1/GLP, EHMT2/G9a | No | 06/13 | |
BI-1950 |
![]() |
Integrin | ITGAL | BI-9446 | Yes | 11/18 |
GSK789 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | GSK791 | No | 02/21 |
ERKi |
![]() |
Kinase | MAPK3, MAPK1 | ERKi-NC | Yes | 05/18 |
MSD-CYP11B2 |
![]() |
Cytochrome P450 | CYP11B2 | MSD-CYP11B2 Negative control | Yes | 06/19 |
BAY1125976 |
![]() |
Kinase | AKT1/2 | BAY-940 | Yes | 11/21 |
BAY-899 |
![]() |
GPCR | LHCGR | BAY-897 | Yes | 01/20 |
CCT369260 |
![]() |
Transcription factor | BCL6 | CCT393732 | Yes | 09/22 |
T-26c |
![]() |
Protease | MMP13 | T-26f | Yes | 05/18 |
TP-030-1 |
![]() |
Kinase | RIPK1 | TP-030n | Yes | 09/20 |
A-192621 |
![]() |
GPCR | EDNRB | A-1806262 | Yes | 03/19 |
8RK64 |
![]() |
Regulator protein | UCHL1 | JYQ88 | Yes | 09/21 |
MRK-560 |
![]() |
Protease | Gamma secretase complex | GSI-NC | Yes | 05/18 |
UNC0642 |
![]() |
Methyltransferase | EHMT2/G9a, EHMT1/GLP | Yes | 08/12 | |
BI 639667 |
![]() |
GPCR | CCR1 | BI-9307 | Yes | 11/18 |
BAY-3153 |
![]() |
GPCR | CCR1 | BAY-173 | Yes | 02/21 |
BI 99179 |
![]() |
Synthase | FASN | BI 99990 | No | 05/18 |
PPTN |
![]() |
GPCR | P2RY14 | PPTN-NC | Yes | 06/19 |
Borussertib |
![]() |
Kinase | AKT1, AKT2 | RL2578 | Yes | 10/21 |
A-485 |
![]() |
Transferase | EP300, CREBBP | A-486 | Yes | 05/18 |
JNJ-6204 |
![]() |
Kinase | CSNK1D/CSNK1E | JNJ-0293 | Yes | 09/22 |
PF-04457845 |
![]() |
Hydrolase | FAAH | PF-04875474 | Yes | 05/18 |
Ogerin |
![]() |
GPCR | GPR68 | ZINC32547799 | Yes | 06/20 |
TP-024 |
![]() |
GPCR | GPR52 | TP-024n | Yes | 11/18 |
BI-1942 |
![]() |
Protease | CMA1 | No | 06/21 | |
MRL-650 |
![]() |
GPCR | CNR1 | MRL-CB1-NC | Yes | 05/18 |
NI-57 |
![]() |
Bromodomains | BRPF1, BRD1, BRPF3 | No | 12/14 | |
A-1155463 |
![]() |
Regulator protein | BCL2L1 | A-1107969 | Yes | 11/19 |
GSK343 |
![]() |
Methyltransferase | EZH2 | No | 08/12 | |
BAY-885 |
![]() |
Kinase | MAPK7 | BAY-693 | No | 11/18 |
BI 207127 |
![]() |
RNA polymerase | HCV NS5B | BI-7656 | Yes | 11/20 |
TP-008 |
![]() |
Kinase | ACVR1B, TGFBR1 | Al11 | No | 06/19 |
MSC-4381 |
![]() |
Monocarboxylate transporter | SLC16A3 | MSC-0516 | Yes | 09/21 |
TP-004 |
![]() |
Protease | METAP2 | TPn-004 | Yes | 05/18 |
(R)-9s |
![]() |
GPCR | ADRA1D | (S)-9s | Yes | 05/18 |
SR-302 |
![]() |
Kinase | DDR1, DDR2, MAPK11, MAPK14 | SR-301 | No | 06/20 |
IOX2 (requires >>> 1 microM for cell assays) |
![]() |
2OG | PHD2 | No | 02/12 | |
TP-020 |
![]() |
Transferase | MGAT2 | TP-020n | Yes | 11/18 |
GSK973 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | GSK943 | Yes | 02/21 |
BAY-826 |
![]() |
Kinase | TIE1, TEK, DDR1, DDR2 | BAY-309 | Yes | 05/18 |
BI-9564 |
![]() |
Bromodomains | BRD9, BRD7 | Yes | 04/15 | |
IPP/CNRS-A017 |
![]() |
Dehydrogenase | DHODH | IPP/CNRS-A019 | No | 10/19 |
TP-051 |
![]() |
GPCR | FFAR1 | TP-051n | Yes | 09/22 |
BAY 1816032 |
![]() |
Kinase | BUB1 | BAY-283 | Yes | 10/22 |
PFI-1 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | No | 11/11 | |
A-079 |
![]() |
Ion channel | TRPA1 | A-226 | Yes | 11/18 |
BAY-390 |
![]() |
Ion channel | TRPA1 | BAY-9897 | Yes | 09/20 |
UCSF924 |
![]() |
GPCR | DRD4 | UCSF924NC | Yes | 04/19 |
JNJ-54119936 |
![]() |
Nuclear hormone receptor | RORC | JNJ-53721590 | Yes | 09/21 |
PF-04418948 |
![]() |
GPCR | PTGER2 | PF-04475866 | Yes | 05/18 |
BTZO-1 |
![]() |
Cytokine | MIF | BTZO-4 | No | 05/18 |
BAY-3827 |
![]() |
Kinase | PRKAA1, RPS6KA1 | BAY-974 | No | 01/20 |
BAZ2-ICR |
![]() |
Bromodomains | BAZ2A, BAZ2B | Yes | 05/14 | |
BAY-1797 |
![]() |
Ion channel | P2X4 | BAY-207 | Yes | 11/18 |
GSK046 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | Yes | 02/21 | |
ABT-724 |
![]() |
GPCR | DRD4 | A-769 | Yes | 05/18 |
OF-1 |
![]() |
Bromodomains | BRPF1, BRD1, BRPF3 | No | 07/14 | |
A-1596586 |
![]() |
Ion channel | CFTR | A-1596584 | No | 06/19 |
GNE-2256 |
![]() |
Kinase | IRAK4 | GNE-6689 | Yes | 11/21 |
BAY-179 |
![]() |
Complex I | BAY-070 | Yes | 01/20 | |
SAFit2 |
![]() |
Isomerase | FKBP5 | ddSAFit2 | Yes | 09/22 |
BAY-876 |
![]() |
Solute carriers | SLC2A1 | BAY-588 | Yes | 05/18 |
TP-030-2 |
![]() |
Kinase | RIPK1 | TP-030n | Yes | 09/20 |
BAY-293 |
![]() |
Nucleotide exchange factor | SOS1 | BAY-294 | No | 04/19 |
TP-040 |
![]() |
Hydrolase | OGA | TP-040n | Yes | 09/21 |
GSM1 |
![]() |
Protease | Gamma secretase complex | GSM-NC | Yes | 05/18 |
BAY-707 |
![]() |
Hydrolase | NUDT1 | BAY-604 | Yes | 05/18 |
Skepinone-L |
![]() |
Kinase | MAPK14 | FM-743 | Yes | 01/20 |
IOX1 (tool compound) |
![]() |
2OG | Pan-KDM | No | 01/12 | |
BI 653048 |
![]() |
Nuclear hormone receptor | NR3C1 | BI-3047 | Yes | 11/18 |
GSK778 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | Yes | 02/21 | |
BAY-7598 |
![]() |
Protease | MMP12 | BAY-694 | Yes | 05/18 |
THPP-1 |
![]() |
Phosphodiesterase | PDE10A | THPP-1-NC | Yes | 06/19 |
JNJ-65355394 |
![]() |
Hydrolase | OGA | JNJ-73924149 | Yes | 11/21 |
JNJ-39758979 |
![]() |
GPCR | HRH4 | JNJ-39668551 | Yes | 09/22 |
ABT-546 |
![]() |
GPCR | EDNRA | A-545 | Yes | 05/18 |
(R)-ZINC-3573 |
![]() |
GPCR | MRGPRX2 | (S)-ZINC-3573 | No | 06/20 |
BI-1230 |
![]() |
Protease | HCV NS3 | BI-1675 | Yes | 03/19 |
A-446 |
![]() |
Hydrolase | GLS | A-426 | Yes | 07/21 |
MRL-SYKi |
![]() |
Kinase | SYK | MRL-SYKi-NC | Yes | 05/18 |
BAY-985 |
![]() |
Kinase | TBK1, IKBKE | BAY-440 | Yes | 01/20 |
I-CBP112 |
![]() |
Bromodomains | CREBBP, EP300 | No | 03/13 | |
BI-2545 |
![]() |
Phosphodiesterase | ENPP2 | BI-3017 | Yes | 11/18 |
BAY-6672 |
![]() |
GPCR | PTGFR | BAY-403 | Yes | 11/20 |
BAY-474 |
![]() |
Kinase | MET | BAY-827 | Yes | 05/18 |
BAY-549 |
![]() |
Kinase | ROCK1, ROCK2 | BAY-4900 | Yes | 06/19 |
BAY-091 |
![]() |
Kinase | PIP4K2A | BAY-0361 | No | 10/21 |
BI-9627 |
![]() |
Solute carriers | SLC9A1 | BI-0054 | Yes | 05/18 |
BI-2081 |
![]() |
GPCR | FFAR1 | BI-0340 | Yes | 09/22 |
KISS1-305 |
![]() |
GPCR | KISS1R | KISS1-543 | Yes | 05/18 |
WM-1119 |
![]() |
Transferase | KAT6A, KAT6B | WM-2474 | Yes | 06/20 |
TP-021 |
![]() |
Transcription factor | BCL6 | TP-021n | Yes | 11/18 |
BI 605906 |
![]() |
Kinase | IKBKB | BI-5026 | Yes | 06/21 |
CRTH2 antagonist |
![]() |
GPCR | PTGDR2 | CRTH2 negative control | Yes | 05/18 |
I-BRD9 |
![]() |
Bromodomains | BRD9 | No | 05/15 | |
A-1211212 |
![]() |
Regulator protein | BCL2 | A-1210227 | Yes | 11/19 |
JQ1 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | (-)-JQ1 | Yes | 06/10 |
PFI-2 |
![]() |
Methyltransferase | SETD7 | (S)-PFI-2 | No | 05/13 |
LP99 |
![]() |
Bromodomains | BRD9, BRD7 | 2S,3R-enantiomer | No | 12/14 |
A-196 |
![]() |
Methyltransferase | SUV420H1, SUV420H2 | A-197, SGC2043 | No | 07/15 |
A-395 |
![]() |
WD40 repeat | EED | A-395N | 07/16 | |
A-485 |
![]() |
Lysine acetyltransferase | CREBBP, EP300 | A-486 | 10/17 | |
TP-008 |
![]() |
Kinase | ALK4, ALK5 | AI11 | No | 05/19 |
BAY-299 |
![]() |
Bromodomains | TAF1, BRD1 | BAY-364 | No | 06/16 |
BAY-598 |
![]() |
Methyltransferase | SMYD2 | BAY-369 | Yes | 04/15 |
BAY-6035 |
![]() |
Methyltransferase | SMYD3 | BAY-444 | 06/17 | |
BAY-850 |
![]() |
Bromodomains | ATAD2 | BAY-460 | 01/17 | |
BAY-678 |
![]() |
Protease | ELANE | BAY-677 | Yes | 10/15 |
BAY-805 |
![]() |
USP (ubiquitin specific protease) | USP21 | BAY-728 | No | 10/22 |
SGC-CBP30 |
![]() |
Bromodomains | CREBBP, EP300 | BDOIA513 | No | 03/13 |
BI-9321 |
![]() |
Methyl Lysine Binder | NSD3 | BI-9466 | 07/18 | |
BI01383298 |
![]() |
Solute carriers | SLC13A5 | BI01372674 | 01/18 | |
CK156 |
![]() |
Kinase | STK17A, DRAK1 | CKJB71 | No | 10/21 |
CS640 |
![]() |
Kinase | CAMK1 | CS640s | Yes | 01/23 |
L-Moses |
![]() |
Bromodomains | KAT2A, KAT2B | D-Moses | Yes | 10/17 |
DDR-TRK-1 |
![]() |
Kinase | DDR, TRK | DDR-TRK-1N | Yes | 08/18 |
FM-381 |
![]() |
Kinase | JAK3 | FM-479 | 02/17 | |
GSK-J1 use pro-drug GSK-J4 for cell assays |
![]() |
Lysine Demethylase | KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B | GSK-J2 (GSK-J5) | No | 07/12 |
GSK484 |
![]() |
Arginine deiminases | PAD4 | GSK106 | Yes | 03/15 |
GSK4027 |
![]() |
Bromodomains | KAT2A, KAT2B | GSK4028 | 06/17 | |
GSK2801 |
![]() |
Bromodomains | BAZ2A, BAZ2B | GSK8573 | Yes | 12/14 |
GSK8814 |
![]() |
Bromodomains | ATAD2, ATAD2B | GSK8815 | 01/17 | |
GSK6853 |
![]() |
Bromodomains | BRPF1 | GSK9311 | Yes | 01/17 |
GSK864 |
![]() |
Dehydrogenase | IDH1 | GSK990 | Yes | 11/15 |
LLY-283 |
![]() |
Methyltransferase | PRMT5 | LLY-284 | 07/16 | |
M4K2234 |
![]() |
Kinase | ALK1, ALK2 | M4K2234NC | Yes | 02/22 |
MRIA9 |
![]() |
Kinase | SIK1, SIK2, SIK3 | MR7 | Yes | 08/21 |
MRK-740 |
![]() |
Methyltransferase | PRDM9 | MRK-740-NC | 06/18 | |
MRK-952 |
![]() |
Hydrolase | NUDT5 | MRK-952-NC | No | 10/22 |
MRK-990 |
![]() |
Methyltransferase | PRMT9, PRMT5 | MRK-990-NC | No | 10/22 |
MS049 |
![]() |
Methyltransferase | CARM1, PRMT6 | MS049N | No | 06/15 |
MS023 |
![]() |
Methyltransferase | PRMT1, PRMT3, CARM1, PRMT6, PRMT8 | MS094 | No | 07/15 |
MSC1186 |
![]() |
Kinase | SRPK | MSC5360 | 01/23 | |
MU1210 |
![]() |
Kinase | CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 | MU140 | No | 05/19 |
MU1700 |
![]() |
Kinase | ALK1, ALK2 | MU1700NC | Yes | 02/22 |
MU1742 |
![]() |
Kinase | CK1δ, CK1ε | MU2027 | Yes | 10/22 |
Homer |
![]() |
WD40 repeat | WDR5 | nc_WDR5 and nc_VHL | No | 07/21 |
NR162 |
![]() |
Kinase | CASK | NR187 | No | 09/20 |
NVS-BPTF-1 |
![]() |
Bromodomains | BPTF | NVS-BPTF-C | No | 02/19 |
NVS-CECR2-1 |
![]() |
Bromodomains | CECR2 | NVS-CECR2-C | No | 06/15 |
NVS-MLLT-1 |
![]() |
YEATS | MLLT1, MLLT3 | NVS-iMLLT-C | No | 03/20 |
NVS-PAK1-1 |
![]() |
Kinase | PAK1 | NVS-PAK1-C | No | 06/16 |
OICR-9429 |
![]() |
WD40 repeat | WDR5 | OICR-0547 | No | 05/14 |
PFI-3 |
![]() |
Bromodomains | SMARCA2, PBRM1, SMARCA4 | PFI-3oMet | No | 11/13 |
PFI-5 |
![]() |
Methyltransferase | SMYD2 | PFI-5N | 07/17 | |
PFI-6 |
![]() |
YEATS | MLLT1, MLLT3 | PFI-6N | No | 06/20 |
PFI-7 |
![]() |
E3 ligase | GID4 | PFI-7N | No | 09/21 |
SGC-AAK1-1 |
![]() |
Kinase | AAK1, BMP2K, BIKE | SGC-AAK1-1N | 02/18 | |
SGC-SMARCA-BRDVIII |
![]() |
Bromodomains | PB1(5), SMARCA2/4 | SGC-BRDVIII-NC | 12/20 | |
SGC-CAMKK2-1 |
![]() |
Kinase | CAMKK1, CAMKK2 | SGC-CAMKK2-1N | No | 01/20 |
SGC-CK2-1 |
![]() |
Kinase | CSNK2A1, CSNK2A2 | SGC-CK2-1N | No | 06/20 |
SGC-CLK-1 |
![]() |
Kinase | CLK1, CLK2, CLK4 | SGC-CLK-1N | No | 02/20 |
SGC-GAK-1 |
![]() |
Kinase | GAK | SGC-GAK-1N | 02/18 | |
SGC-PI5P4Kγ/MYLK4-1 |
![]() |
Kinase | PI5P4K gamma, MYLK4 | SGC-PI5P4Kγ/MYLK4-1N | No | 05/23 |
SGC-PIKFYVE-1 |
![]() |
Kinase | PIKfyve | SGC-PIKFYVE-1N | No | 10/22 |
SGC-STK17B-1 |
![]() |
Kinase | STK17B, DRAK2 | SGC-STK17B-1N | 02/20 | |
SGC-UBD253 |
![]() |
UBD (ubiquitin binding domain) | HDAC6 | SGC-UBD253N | No | 01/22 |
SGC0946 |
![]() |
Methyltransferase | DOT1L | SGC0649 | No | 08/12 |
GSK591 |
![]() |
Methyltransferase | PRMT5 | SGC2096 | No | 07/15 |
SGC3027 |
![]() |
Methyltransferase | PRMT7 | SGC3027N | 03/18 | |
SGC6870 |
![]() |
Methyltransferase | PRMT6 | SGC6870N | 06/19 | |
LLY-507 (Multiple Off-target Effects) |
![]() |
Methyltransferase | SMYD2 | SGC705 | No | 11/13 |
SGC-CK2-2 |
![]() |
Kinase | CK2/CSNK2 | SGK-CK2-2N | 05/23 | |
SKI-73 |
![]() |
Methyltransferase | CARM1 | SKI-73N | 07/17 | |
T-26c |
![]() |
Protease | MMP13 | T-26f | 06/16 | |
T3-CLK |
![]() |
Kinase | CLK1, CLK2, CLK3, CLK4 | T3-CLK-N | No | 05/19 |
TH-257 |
![]() |
Kinase | LIMK1, LIMK2 | TH-263 | 07/17 | |
TP-064 |
![]() |
Methyltransferase | CARM1 | TP-064N | 06/16 | |
TP-238 |
![]() |
Bromodomains | CECR2, BPTF | TP-422 | 09/18 | |
TP-472 |
![]() |
Bromodomains | BRD9, BRD7 | TP-472N | Yes | 06/16 |
UNC0638 |
![]() |
Methyltransferase | EHMT2/G9a, EHMT1/GLP | UNC0737 | No | 06/10 |
UNC1215 |
![]() |
Methyl Lysine Binder | L3MBTL3 | UNC1079 | No | 08/12 |
UNC1999 |
![]() |
Methyltransferase | EZH2 | UNC2400 | Yes | 05/13 |
UNC6934 |
![]() |
Methyl Lysine Binder | NSD2-PWWP1 | UNC7145 | 06/19 | |
VinSpinIn |
![]() |
Spindlin domains | Spin1 | VinSpinIC | 09/18 | |
SGC707 |
![]() |
Methyltransferase | PRMT3 | XY1 | No | 06/14 |
Chemical Handles
This versatile modality can be used to develop tools for proximity-inducing chemistry, tracers for target engagement assays, PROTACs, chemical inducers of degradation, and pull-down reagents. Handles bind their target with Kd < 1 micromolar. Their selectivity and cell activity has not been determined.
Chemical Handle | Chemical Probe | Structures | Protein family | Specific Targets |
Control![]() |
In Vivo Activity* | Added |
---|---|---|---|---|---|---|---|
PFI-E3H1 | PFI-7 |
![]() |
E3 ligase | GID4 | PFI-7N | No | 09/21 |
Please select a protein family