Chemical Probes

Please select a protein family

( ( ( ASH1L:0.42656, ( SP100:0.36789, ( SP110:0.33224, ( SP140:0.13671, SP140L:0.10984) :0.20058) :0.03793) :0.06052) :0.01373, ( ( ( ATAD2:0.26940, ATAD2B:0.26369) :0.19033, ( ( ( ( ( BRD1:0.22380, BRPF3:0.22705) :0.01451, BRPF1:0.23801) :0.20719, ( ( ( ( ( ( BRD2:0.19557, BRD3:0.19148) :0.04050, BRD4:0.25182) :0.02415, BRDT:0.28925) :0.14057, PBRM1:0.44189) :0.00803, ( CREBBP:0.20246, EP300:0.20268) :0.23148) :0.00872, ( ( BRD7:0.33523, BRD9:0.32809) :0.08483, ( CECR2:0.43144, KIAA2026:0.43985) :0.00515) :0.00941) :0.00414) :0.00503, ( ( BRWD1:0.23336, ( BRWD3:0.23371, PHIP:0.22856) :0.00717) :0.20977, ( ZMYND11:0.36547, ZMYND8:0.37118) :0.07274) :0.01167) :0.00465, ( TAF1:0.04053, TAF1L:0.04161) :0.41155) :0.00158) :0.00393, BRD8:0.44351) :0.00285) :0.00187, ( ( ( BAZ1A:0.40491, BAZ1B:0.40021) :0.02117, ( BAZ2A:0.35523, BAZ2B:0.35501) :0.06222) :0.02521, ( MLL:0.41568, ( ( ( TRIM24:0.25638, TRIM33:0.25600) :0.09230, TRIM28:0.34971) :0.03714, TRIM66:0.38654) :0.04652) :0.01663) :0.00258, ( ( BPTF:0.42133, ( KAT2A:0.15500, KAT2B:0.14788) :0.26722) :0.02034, ( SMARCA2:0.11640, SMARCA4:0.11442) :0.33318) :0.00435);
( ( ( ( JARID2:0.43039, ( ( ( ( KDM4A/JMJD2A:0.23155, KDM4C/JMJD2C:0.23341) :0.01707, KDM4B/JMJD2B:0.24566) :0.01607, ( KDM4D/JMJD2D:0.16619, KDM4DL/JMJD2E:0.17175) :0.06332) :0.15741, ( ( KDM5A/JARID1A:0.23147, KDM5B/JARID1B:0.24003) :0.02678, ( KDM5C/JARID1C:0.06805, KDM5D/JARID1D:0.07750) :0.18760) :0.14048) :0.03729) :0.01341, ( MINA:0.35985, NO66/FLJ21802:0.34553) :0.09246) :0.00726, ( ( ( JHDM1D/KIAA1718:0.30283, ( PHF2:0.26273, PHF8:0.26463) :0.04507) :0.10219, ( KDM2A/FBXL11:0.24364, KDM2B/FBXL10:0.23571) :0.16985) :0.01908, JMJD6:0.41429) :0.03462) :0.00458, ( ( JMJD1C:0.30946, ( KDM3A/JMJD1A:0.26975, KDM3B/JMJD1B:0.25258) :0.06381) :0.12378, ( JMJD5:0.43831, ( ( KDM6A/UTX:0.06705, UTY:0.06732) :0.27041, KDM6B/JMJD3:0.33895) :0.11043) :0.01232) :0.00148, ( KDM1A/LSD1:0.38589, KDM1B/LSD2:0.38297) :0.08988);
( ( L3MBTL:0.26880, ( ( L3MBTL2:0.22568, MBTD1:0.22655) :0.17920, ( ( SCMH1:0.26354, SCML2:0.26828) :0.12779, ( SFMBT1:0.22793, SFMBT2:0.23512) :0.13803) :0.02634) :0.10947) :0.01818, L3MBTL3:0.27089, L3MBTL4:0.23794);
( ( ( ( ( ( ( ASH1L:0.41664, ( ( SETD3:0.41040, SETD4:0.41233) :0.00239, SETD6:0.41336) :0.04317) :0.00783, ( ( ( ( SMYD1:0.34933, SMYD3:0.34226) :0.00652, SMYD2:0.34805) :0.05781, SMYD4:0.40382) :0.01255, SMYD5:0.42036) :0.03407) :0.00364, ( ( ( ( CARM1:0.35324, ( PRMT2:0.33715, PRMT6:0.32951) :0.01450) :0.01142, ( ( PRMT1:0.11741, PRMT8:0.11805) :0.16780, PRMT3:0.29132) :0.07270) :0.06188, ( PRMT7:0.41262, PRMT9:0.40675) :0.01709) :0.03029, PRMT5:0.44807) :0.01398) :0.00463, ( ( ( ( CAMKMT:0.42587, EEF2KMT:0.42552) :0.00950, ( ( METTL21A:0.35150, METTL21D:0.34116) :0.03059, METTL21C:0.37356) :0.05156) :0.00986, SETD2:0.41629) :0.01686, ( ( ( ( ( ( EHMT1/GLP:0.26312, EHMT2/G9A:0.26663) :0.10422, ( SUV39H1:0.20671, SUV39H2:0.20548) :0.16629) :0.02669, ( SETDB1:0.34392, SETDB2:0.35705) :0.06209) :0.01897, SETMAR:0.43380) :0.00575, ( NSD1:0.28947, ( WHSC1:0.28335, WHSC1L1:0.28588) :0.02046) :0.12647) :0.01053, ( ( ( EZH1:0.17720, EZH2:0.17535) :0.24657, SETD7:0.43372) :0.01694, ( ( MLL:0.31117, MLL4:0.31609) :0.05423, SETD8:0.39677) :0.03148) :0.00684) :0.00558) :0.00421) :0.00550, ( ( ( ( MECOM:0.23499, PRDM16:0.22172) :0.19790, ( PRDM13:0.40625, PRDM8:0.41523) :0.01377) :0.01047, ( METTL20:0.41561, PRDM2:0.40118) :0.02407) :0.00891, ( ( ( PRDM1:0.41095, ( ( ( PRDM12:0.34755, PRDM6:0.35817) :0.02348, PRDM14:0.38137) :0.01014, PRDM4:0.40304) :0.01522) :0.00630, ( ( PRDM15:0.36547, PRDM5:0.38056) :0.03066, ( PRDM7:0.13090, PRDM9:0.11910) :0.29272) :0.00897) :0.00944, ( PRDM10:0.41440, PRDM11:0.41339) :0.00558) :0.02345) :0.00880) :0.00378, ( MLL5:0.34249, SETD5:0.34753) :0.10101) :0.00319, ( DOT1L:0.43970, ( ( FBL:0.43564, ( PCMT1:0.41513, ( SETD1A:0.30089, SETD1B:0.30309) :0.09786) :0.01938) :0.00301, ( MLL2:0.34090, MLL3:0.34348) :0.05345) :0.01186) :0.00212, ( SUV420H1:0.28698, SUV420H2:0.27795) :0.16293);
( ( SPIN1:0.05966, SPIN3:0.09538) :0.01442, ( SPIN2A:0.00390, SPIN2B:0.00000) :0.15225, SPIN4:0.19320);
( ( ( ( ( ( ( ( ( ( ( ( ( A6NM71:0.19599, WDR45:0.20470) :0.09963, WDR45B:0.29608) :0.08691, ( WIPI1:0.23323, WIPI2:0.23314) :0.16096) :0.05462, ( HPS5:0.42495, ( Q6ZS54:0.07930, TECPR2:0.06531) :0.34740) :0.02830) :0.00738, ( ( ( ( ( B3KP68:0.02958, IFT172:0.01983) :0.40428, ( H3BRJ5:0.08519, IFT80:0.08212) :0.34677) :0.01950, ( ( ( ( B4DGB7:0.10634, ( FLJ00025:0.01620, IFT122:0.01417) :0.08590) :0.33152, ( B4E286:0.00099, WDR19:-0.00021) :0.43697) :0.00625, ( B4DX09:0.00715, WDR11:-0.00715) :0.43568) :0.00117, WDR35:0.44480) :0.00621) :0.00259, ( NOL10:0.43979, ( WDR4:0.40993, WDR87:0.39832) :0.01255) :0.01757) :0.00463, ( ( C2ORF44:0.45495, ( RIC1:0.42645, WDPCP:0.44085) :0.01431) :0.01021, ( ( CFAP43:0.40442, WRAP73:0.39775) :0.03042, ( ( CIRH1A:0.01057, UTP4:-0.01057) :0.26437, UTP4B:0.22739) :0.15541) :0.01526) :0.00324) :0.00174) :0.00345, ( ( ( ( ( ARPC1A:0.15819, ARPC1B:0.15532) :0.26205, TULP4:0.42618) :0.01479, ( B4DT22:0.02871, PPWD1:0.02811) :0.42170) :0.00791, ( ( CHAF1B:0.38203, HIRA:0.38363) :0.04882, TBL2:0.42406) :0.01183) :0.00567, ( ( ( ( ( B4E018:0.06432, WDR74:0.07068) :0.34127, TBC1D31:0.43230) :0.01525, ( CFAP57:0.41726, WDR43:0.42173) :0.02215) :0.00643, ( ( IFT140:0.41881, PAK1IP1:0.40262) :0.01842, NEDD1:0.43401) :0.01328) :0.00169, ( ( ( Q9H8N9:0.00036, WDFY1:-0.00036) :0.19830, WDFY2:0.19595) :0.22661, WDR75:0.43841) :0.01209) :0.00368) :0.00262) :0.00142, ( ( ( ( ( ( B3KXN4:0.00113, WDR1:0.00063) :0.20232, B4DZX5:0.20358) :0.19099, NUP214:0.41605) :0.02208, ( B4E3M9:0.05032, BCAS3:0.04158) :0.40645) :0.01139, ( ( LYST:0.39074, WDR73:0.41613) :0.01794, WDR70:0.42844) :0.01302) :0.00482, ( ( ( ( B4DGE3:-0.00339, SEC31B:0.01476) :0.21084, SEC31A:0.22467) :0.20565, ( ( ( ( ( ( ( B4DMH3:0.00480, CORO1C:-0.00252) :0.15714, ( CORO1B:0.07346, Q59F81:0.04849) :0.07712) :0.01779, CORO6:0.16560) :0.00886, CORO1A:0.17512) :0.10337, ( CORO2A:0.17112, CORO2B:0.17054) :0.11519) :0.08192, CORO7:0.35399) :0.00600, Q6ZW98:0.35243) :0.05427) :0.01648, ( ( DMWD:0.20530, WDR20:0.20771) :0.22659, EDC4:0.43492) :0.01149) :0.00762) :0.00284) :0.00084, ( ( ( ( ( B3KP80:0.00256, KCTD3:-0.00040) :0.20355, SHKBP1:0.20559) :0.24354, ( ( LLGL1:0.22912, LLGL2:0.22970) :0.14773, ( STXBP5L:0.17197, STXBP5:0.16774) :0.20385) :0.06098) :0.00826, ( PAN2:0.44184, WDR53:0.40732) :0.01742) :0.00659, ( ( FBXW12:0.44201, WDR91:0.42868) :0.01595, ( WDR72:0.34853, WDR7:0.33569) :0.09711) :0.00847) :0.00188) :0.00094, ( ( ( ( DDB2:0.41348, WDR64:0.41790) :0.02504, ( EIF2A:0.42370, EIF3B:0.42416) :0.03594) :0.00269, ( ( NBAS:0.39925, PREB:0.41130) :0.03107, ( Q8N7X6:0.35163, WDR49:0.33563) :0.09867) :0.01070) :0.00192, ( ( ( ( ( PPP2R2A:0.06095, PPP2R2D:0.05986) :0.02793, ( PPP2R2B:0.06394, PPP2R2C:0.06473) :0.02365) :0.10439, Q59GC6:0.19117) :0.11725, Q6ZP32:0.32295) :0.13007, ( Q8N797:0.11339, WDR17:0.12507) :0.29318) :0.01686) :0.00252) :0.00185, ( ( ( ( AMBRA1:0.42291, ( B4E068:0.18682, WRAP53:0.19616) :0.21323) :0.02271, ( ( ( ( ( B3KUA2:0.00923, TLE3:0.00937) :0.09175, ( ( B4DEF9:0.00629, ( B4E345:0.00247, TLE1:-0.00247) :0.00846) :0.05931, TLE4:0.06588) :0.03599) :0.05206, ( B4DE62:0.03566, TLE2:0.04726) :0.10225) :0.17653, Q59EY9:0.33100) :0.09577, RFWD3:0.44119) :0.00962) :0.00837, ( ( ( ( B3KVI6:0.01383, LRBA:-0.01062) :0.15720, NBEA:0.14845) :0.21809, ( ( ( B4DVX0:0.01445, NBEAL2:-0.01445) :0.22279, NBEAL1:0.22376) :0.14282, NSMAF:0.37265) :0.00570) :0.05341, ( ( WDF3:0.04066, WDFY3:0.01411) :0.33624, WDFY4:0.35214) :0.05767) :0.01384) :0.00290, ( ( ( B7Z6H0:0.00262, SCAP:0.00031) :0.40861, WDR54:0.40729) :0.02915, ( MIOS:0.43207, THOC6:0.39784) :0.02348) :0.00730) :0.00379) :0.00107, ( ( ( ( B4DDD4:0.07776, WDR27:0.08246) :0.34083, ( FBXW4:0.41335, FBXW8:0.42160) :0.01194) :0.01445, ( VPRBP:0.43447, WDR37:0.41978) :0.01648) :0.00551, ( ( ( ( ( ( ( B4DN30:0.05743, DCAF4:0.05227) :0.06312, DCAF4L1:0.11562) :0.01435, DCAF4L2:0.12771) :0.30738, NWD2:0.42207) :0.01402, ( ( DMXL1:0.21995, DMXL2:0.22669) :0.16977, WDR92:0.40662) :0.03040) :0.00562, ( ( FBXW5:0.43540, ( FBXW9:0.40893, WDR81:0.40050) :0.01014) :0.01788, ( LRRK2:0.41772, MED16:0.44545) :0.01573) :0.00671) :0.00053, ( ( DCAF12L1:0.06676, DCAF12L2:0.06499) :0.11804, DCAF12:0.19026) :0.26659) :0.00373) :0.00089) :0.00136, ( ( ( ( ( AAMP:0.40151, ( ( DKFZP779C159:0.00283, KIF21A:0.00177) :0.22040, KIF21B:0.22176) :0.19539) :0.01372, WDR46:0.44082) :0.00864, ( RRP9:0.40700, WDR66:0.42458) :0.02017) :0.00541, ( ( ( B3KRR8:0.00369, WDR6:-0.00075) :0.23320, B4DK45:0.23445) :0.19837, ( GTF3C2:0.43690, ( HERC1:0.37630, NUP43:0.41054) :0.01224) :0.00945) :0.00794) :0.00125, ( CFAP44:0.41208, DCAF7:0.40955) :0.03312) :0.00392) :0.00045, ( ( ( ( ( ( ( ( ( ( ( ( A6P4T4:0.00508, EML4-ALK:-0.00131) :0.00549, B6EXY3:0.00431) :0.00673, A6P4V4:-0.00608) :0.16334, EML4:0.15948) :0.11014, ( ( B3KXA3:0.00255, EML1:0.00113) :0.19920, ( ( B7Z2F5:0.03845, EML2:0.03859) :0.07400, ( B7Z872:0.09969, B7Z918:0.09988) :0.02044) :0.08517) :0.07339) :0.02170, ( B4DL97:0.05251, EML3:0.05016) :0.23941) :0.12143, ( ( EML5:0.12612, EML6:0.12516) :0.24748, THOC3:0.37474) :0.01937) :0.02300, ( ( ( ( ( B4E1H5:-0.00073, CDC20:0.00073) :0.04208, Q2VIM1:0.04564) :0.27443, FZR1:0.32015) :0.03459, CDC20B:0.36376) :0.06893, ( B4E383:0.05144, ERCC8:0.05236) :0.36590) :0.01070) :0.00439, ( ( ( ( B4E2R3:0.09408, MLST8:0.11371) :0.27792, ELP2:0.41424) :0.01052, PRPF4:0.41017) :0.01458, ( BUB3:0.32893, RAE1:0.33876) :0.09452) :0.00675) :0.00252, ( ( ( ( ( B3KMW5:0.00404, WDR3:-0.00404) :0.42113, ( ( EIF3I:0.38888, STRAP:0.38651) :0.00967, UTP15:0.41483) :0.01348) :0.00625, ( ( ( GEMIN5:0.38483, WDR61:0.35287) :0.02545, WDSUB1:0.41275) :0.00266, ( TBL3:0.39295, ( WDR38:0.33694, WDR86:0.36688) :0.01314) :0.01698) :0.01064) :0.00548, ( ( ( B4DYK8:0.04841, WDR97:0.05199) :0.36562, ( PWP2:0.20216, Q59FM2:0.17758) :0.21800) :0.00823, ( WSB1:0.25729, WSB2:0.25756) :0.15581) :0.00778) :0.00546, ( ( ( CFAP52:0.40760, ( MAPKBP1:0.31335, WDR62:0.31281) :0.08255) :0.03133, ( WDR18:0.40917, WDR36:0.41258) :0.02506) :0.00504, ( DCAF13:0.42565, ( GNB1L:0.38044, NWD1:0.39632) :0.02210) :0.01611) :0.00258) :0.00317) :0.00112, ( ( ( ( ( ( ( ( A8MWR8:0.09797, SEC13:0.12883) :0.22721, SEH1L:0.36857) :0.05121, ( RBBP5:0.41351, WDR33:0.40991) :0.01392) :0.00833, ( ( B4E0E6:0.00291, DTL:0.00291) :0.41190, DCAF5:0.42079) :0.01470) :0.00503, ( KATNB1:0.41545, ( NUP37:0.40160, WDHD1:0.41128) :0.01968) :0.01110) :0.00528, ( ( ( B4DTI1:-0.01954, GRWD1:0.02486) :0.37746, ( RBBP4:0.06355, RBBP7:0.06351) :0.33629) :0.02019, ( BRWD1:0.23583, ( BRWD3:0.23125, PHIP:0.23102) :0.00470) :0.17900) :0.01180) :0.00482, ( ( ( B4DVM5:0.05661, WDR24:0.05885) :0.36345, PEX7:0.38687) :0.01489, ( DPH7:0.41974, WDR59:0.41654) :0.02361) :0.01021) :0.00438, ( ( ( ( ( ( B4DVD2:0.07277, GNB2L1:0.08107) :0.15670, B4DWC6:0.23201) :0.13491, WDR48:0.42071) :0.01251, ( ( ( COPA:0.39101, COPB2:0.39155) :0.02132, ( ( POC1A:0.20608, POC1B:0.21652) :0.11242, Q6ZW40:0.32744) :0.05323) :0.01827, PLAA:0.43715) :0.00375) :0.00749, ( WDR31:0.41330, WDR41:0.43138) :0.00923) :0.00689, ( ( ( CDRT1:0.06079, FBXW10:0.05756) :0.16337, Q59EB2:0.22408) :0.19781, TSSC1:0.41803) :0.02706) :0.00381) :0.00246) :0.00127, ( ( ( ( AAAS:0.00368, B4DDU7:0.00217) :0.43512, ( WDR77:0.38904, WDR90:0.37704) :0.02197) :0.01143, ( ( B4DVQ7:0.07250, WDR13:0.09771) :0.32295, DCAF10:0.42018) :0.02014) :0.00519, ( ( BOP1:0.42861, ( CDC40:0.40982, WDR25:0.41555) :0.01395) :0.01001, ( ( ( DCAF11:0.07938, Q59GN6:0.07627) :0.24148, H0YL77:0.33441) :0.09089, RPTOR:0.42585) :0.02229) :0.00618) :0.00430) :0.00076, ( ( ( ( ( ( ( AHI1:0.40130, WDR82:0.37506) :0.03193, ( ( ( B7Z2P6:0.00203, DCAF8:-0.00036) :0.15904, ( DCAF8L1:0.09869, DCAF8L2:0.09965) :0.06455) :0.23254, ( DCAF6:0.39601, WDTC1:0.39276) :0.00502) :0.04073) :0.00164, ( WDR44:0.40029, WDR83:0.35527) :0.03242) :0.01161, ( ( B4DNL1:-0.00363, PWP1:0.00363) :0.42075, LRWD1:0.44242) :0.01277) :0.00198, ( ( EED:0.42523, WDR76:0.43871) :0.00562, ( PALB2:0.43169, WDR89:0.42102) :0.01464) :0.01355) :0.00171, ( ( ( ( ( ( B4DPZ3:0.01412, DYNC1I2:0.01445) :0.00174, B4DX93:0.00613) :0.08999, DYNC1I1:0.10865) :0.30047, ( ( DNAI1:0.37465, WDR78:0.37357) :0.03257, WDR34:0.39929) :0.00653) :0.01937, ( DNAI2:0.37957, WDR63:0.39068) :0.04467) :0.01932, ( ( Q9Y6S1:0.03059, TLE6:0.03453) :0.37107, WDR60:0.41536) :0.03766) :0.00595) :0.00426, ( ( ( ( ( ( ( ( ( ( APAF1:0.38443, DAW1:0.36738) :0.01812, CSTF1:0.41112) :0.01287, ( ( ( DKFZP434D199:0.07977, SNRNP40:0.09346) :0.27479, WDR26:0.41317) :0.01004, ( ( PAFAH1B1:0.36051, ( WDR5B:0.07428, WDR5:0.07421) :0.26255) :0.01033, SMU1:0.39458) :0.02006) :0.00695) :0.00182, WDR88:0.41658) :0.00436, ( ( ( ( B4E074:0.00110, NLE1:0.00107) :0.00847, B4E303:0.01076) :0.38001, ( ( ( ( ( GNB1:0.04553, GNB4:0.04565) :0.00324, GNB2:0.04970) :0.04388, GNB3:0.09509) :0.14002, GNB5:0.24491) :0.13609, SPAG16:0.39576) :0.01277) :0.00607, WDR47:0.42413) :0.01224) :0.00333, ( ( ( ( BTRC:0.08136, FBXW11:0.07915) :0.29724, ( FBXW7:0.06995, Q53F40:0.07040) :0.30417) :0.02436, FBXW2:0.40974) :0.02740, ( PIK3R4:0.41642, WDR12:0.39446) :0.02518) :0.00374) :0.00073, ( ( DKFZP451A177:0.00547, ZNF106:-0.00304) :0.42524, TRAF7:0.42429) :0.01771) :0.00158, ( ( ( ( ( B7Z475:-0.00641, TBL1XR1:0.00641) :0.06013, ( TBL1X:0.04446, TBL1Y:0.04175) :0.02600) :0.32034, CIAO1:0.36726) :0.02291, ( ( STRN3:0.18112, STRN:0.18299) :0.05937, STRN4:0.23401) :0.18763) :0.00531, ( PLRG1:0.41162, ( PRPF19:0.40837, ( TAF5L:0.30796, TAF5:0.30834) :0.09896) :0.00834) :0.00738) :0.00813) :0.00255, ( ( ( ( ATG16L1:0.00344, Q9NWG8:0.01275) :0.25871, Q8TCI4:0.23490) :0.11177, ( ATG16L2:0.18566, FLJ00012:0.16049) :0.19150) :0.05598, ( ( Q59EZ2:0.00688, TEP1:0.00047) :0.37045, WDR55:0.39349) :0.02789) :0.00450) :0.00338, ( ( DENND3:0.43279, UTP18:0.42873) :0.01247, ( PAAF1:0.40268, RFWD2:0.41875) :0.01927) :0.01205) :0.00286) :0.00102);
((MLLT1:0.23658,MLLT3:0.23569):0.22518,YEATS2:0.36660,YEATS4:0.35586);

Chemical Probes

Potent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories.

SGC chemical probes are open-access reagents that are meant to be used by  the biomedical research community with no restrictions on use. To acquire a sample, follow the links on the webpage of your desired chemical probe. You can sort the table by clicking the column headers.

The SGC probes set is complemented by the donated probe set

Namesort descending Structures Protein family Specific Targets Control In Vivo Activity* Added
(R)-9s GPCR ADRA1D (S)-9s Yes 05/18
(R)-ZINC-3573 GPCR MRGPRX2 (S)-ZINC-3573 No 06/20
8RK64 Regulator protein UCHL1 JYQ88 Yes 09/21
A-079 Ion channel TRPA1 A-226 Yes 11/18
A-1155463 Regulator protein BCL2L1 A-1107969 Yes 11/19
A-1211212 Regulator protein BCL2 A-1210227 Yes 11/19
A-1596586 Ion channel CFTR A-1596584 No 06/19
A-192621 GPCR EDNRB A-1806262 Yes 03/19
A-196
Methyltransferase SUV420H1, SUV420H2 A-197, SGC2043 No 07/15
A-366
Methyltransferase EHMT1/GLP, EHMT2/G9a No 06/13
A-395
WD40 repeat EED A-395N 07/16
A-446 Hydrolase GLS A-426 Yes 07/21
A-485 Transferase EP300, CREBBP A-486 Yes 05/18
A-485
Lysine acetyltransferase CREBBP, EP300 A-486 10/17
ABT-100 Transferase FNTB A-108 Yes 05/18
ABT-546 GPCR EDNRA A-545 Yes 05/18
ABT-724 GPCR DRD4 A-769 Yes 05/18
BAY-069 Amino acid transaminase BCAT1, BCAT2 BAY-771 Yes 09/20
BAY-091 Kinase PIP4K2A BAY-0361 No 10/21
BAY-179 Complex I BAY-070 Yes 01/20
BAY-1797 Ion channel P2X4 BAY-207 Yes 11/18
BAY-293 Nucleotide exchange factor SOS1 BAY-294 No 04/19
BAY-299
Bromodomains TAF1, BRD1 BAY-364 No 06/16
BAY-3153 GPCR CCR1 BAY-173 Yes 02/21
BAY-3827 Kinase PRKAA1, RPS6KA1 BAY-974 No 01/20
BAY-386 GPCR F2R BAY-448 Yes 05/18
BAY-390 Ion channel TRPA1 BAY-9897 Yes 09/20
BAY-474 Kinase MET BAY-827 Yes 05/18
BAY-549 Kinase ROCK1, ROCK2 BAY-4900 Yes 06/19
BAY-598
Methyltransferase SMYD2 BAY-369 Yes 04/15
BAY-6035
Methyltransferase SMYD3 BAY-444 06/17
BAY-6672 GPCR PTGFR BAY-403 Yes 11/20
BAY-678
Protease ELANE BAY-677 Yes 10/15
BAY-678 Protease ELANE BAY-677 Yes 05/18
BAY-707 Hydrolase NUDT1 BAY-604 Yes 05/18
BAY-7598 Protease MMP12 BAY-694 Yes 05/18
BAY-784 GPCR GNRHR BAY-786 Yes 11/18
BAY-826 Kinase TIE1, TEK, DDR1, DDR2 BAY-309 Yes 05/18
BAY-850
Bromodomains ATAD2 BAY-460 01/17
BAY-876 Solute carriers SLC2A1 BAY-588 Yes 05/18
BAY-885 Kinase MAPK7 BAY-693 No 11/18
BAY-899 GPCR LHCGR BAY-897 Yes 01/20
BAY-985 Kinase TBK1, IKBKE BAY-440 Yes 01/20
BAY1125976 Kinase AKT1/2 BAY-940 Yes 11/21
BAZ2-ICR
Bromodomains BAZ2A, BAZ2B Yes 05/14
BI 207127 RNA polymerase HCV NS5B BI-7656 Yes 11/20
BI 605906 Kinase IKBKB BI-5026 Yes 06/21
BI 639667 GPCR CCR1 BI-9307 Yes 11/18
BI 653048 Nuclear hormone receptor NR3C1 BI-3047 Yes 11/18
BI 665915 Lipoxygenase ALOX5AP BI-0153 Yes 05/18
BI 99179 Synthase FASN BI 99990 No 05/18
BI-1230 Protease HCV NS3 BI-1675 Yes 03/19
BI-1935 Hydrolase EPHX2 BI-2049 Yes 05/18
BI-1942 Protease CMA1 No 06/21
BI-1950 Integrin ITGAL BI-9446 Yes 11/18
BI-2540 Reverse transcriptase HIV NNRT BI-2439 Yes 11/20
BI-2545 Phosphodiesterase ENPP2 BI-3017 Yes 11/18
BI-4394 Protease MMP13 BI-4395 Yes 11/18
BI-9321
Methyl Lysine Binder NSD3 BI-9466 07/18
BI-9564
Bromodomains BRD9, BRD7 Yes 04/15
BI-9627 Solute carriers SLC9A1 BI-0054 Yes 05/18
BI01383298
Solute carriers SLC13A5 BI01372674 01/18
Borussertib Kinase AKT1, AKT2 RL2578 Yes 10/21
Bromosporine (BSP)
(tool compound)
Bromodomains pan-Bromodomain No 01/13
BTZO-1 Cytokine MIF BTZO-4 No 05/18
CK156
Kinase STK17A, DRAK1 CKJB71 No 10/21
CRTH2 antagonist GPCR PTGDR2 CRTH2 negative control Yes 05/18
DDR-TRK-1
Kinase DDR, TRK DDR-TRK-1N Yes 08/18
ERKi Kinase MAPK3, MAPK1 ERKi-NC Yes 05/18
FM-381
Kinase JAK3 FM-479 02/17
FS-694 Kinase MAPK14 FM-743 No 01/20
GNE-2256 Kinase IRAK4 GNE-6689 Yes 11/21
GSK-J1
use pro-drug GSK-J4 for cell assays
Lysine Demethylase KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B GSK-J2 (GSK-J5) No 07/12
GSK-LSD1
Lysine Demethylase KDM1A/LSD1 No 03/14
GSK046 Bromodomains BRD2, BRD3, BRD4, BRDT Yes 02/21
GSK2801
Bromodomains BAZ2A, BAZ2B GSK8573 Yes 12/14
GSK343
Methyltransferase EZH2 No 08/12
GSK4027
Bromodomains KAT2A, KAT2B GSK4028 06/17
GSK484
Arginine deiminases PAD4 GSK106 Yes 03/15
GSK591
Methyltransferase PRMT5 SGC2096 No 07/15
GSK620 Bromodomains BRD2, BRD3, BRD4, BRDT Yes 02/21
GSK6853
Bromodomains BRPF1 GSK9311 Yes 01/17
GSK778 Bromodomains BRD2, BRD3, BRD4, BRDT Yes 02/21
GSK789 Bromodomains BRD2, BRD3, BRD4, BRDT GSK791 No 02/21
GSK864
Dehydrogenase IDH1 GSK990 Yes 11/15
GSK8814
Bromodomains ATAD2, ATAD2B GSK8815 01/17
GSK973 Bromodomains BRD2, BRD3, BRD4, BRDT GSK943 Yes 02/21
GSM1 Protease Gamma secretase complex GSM-NC Yes 05/18
Homer
WD40 repeat WDR5 nc_WDR5 and nc_VHL No 07/21
I-BRD9
Bromodomains BRD9 No 05/15
I-CBP112
Bromodomains CREBBP, EP300 No 03/13
IOX1
(tool compound)
2OG Pan-KDM No 01/12
IOX2
(requires >>> 1 microM for cell assays)
2OG PHD2 No 02/12
IPP/CNRS-A017 Dehydrogenase DHODH IPP/CNRS-A019 No 10/19
JNJ-42396302 Phosphodiesterase PDE10A JNJ-40573663 Yes 09/21
JNJ-54119936 Nuclear hormone receptor RORC JNJ-53721590 Yes 09/21
JNJ-65355394 Hydrolase OGA JNJ-73924149 Yes 11/21
JQ1
Bromodomains BRD2, BRD3, BRD4, BRDT (-)-JQ1 Yes 06/10
KISS1-305 GPCR KISS1R KISS1-543 Yes 05/18
L-Moses
Bromodomains KAT2A, KAT2B D-Moses Yes 10/17
LLY-283
Methyltransferase PRMT5 LLY-284 07/16
LLY-507
(Multiple Off-target Effects)
Methyltransferase SMYD2 SGC705 No 11/13
LP99
Bromodomains BRD9, BRD7 2S,3R-enantiomer No 12/14
MLi-2 Kinase LRRK2 MLi-2-NC Yes 05/19
MRIA9
Kinase SIK1, SIK2, SIK3 MR7 Yes 08/21
MRK-560 Protease Gamma secretase complex GSI-NC Yes 05/18
MRK-740
Methyltransferase PRDM9 MRK-740-NC 06/18
MRL-650 GPCR CNR1 MRL-CB1-NC Yes 05/18
MRL-SYKi Kinase SYK MRL-SYKi-NC Yes 05/18
MS023
Methyltransferase PRMT1, PRMT3, CARM1, PRMT6, PRMT8 MS094 No 07/15
MS049
Methyltransferase CARM1, PRMT6 MS049N No 06/15
MSC-4381 Monocarboxylate transporter SLC16A3 MSC-0516 Yes 09/21
MSD-CYP11B2 Cytochrome P450 CYP11B2 MSD-CYP11B2 Negative control Yes 06/19
MSD-M1PAM GPCR CHRM1 MSD-M1PAM-NC Yes 08/19
MU1210
Kinase CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 MU140 No 05/19
NI-57
Bromodomains BRPF1, BRD1, BRPF3 No 12/14
NR162
Kinase CASK NR187 No 09/20
NVS-BPTF-1
Bromodomains BPTF NVS-BPTF-C No 02/19
NVS-CECR2-1
Bromodomains CECR2 NVS-CECR2-C No 06/15
NVS-MALT1 Protease MALT1 NVS-MALT1-C Yes 02/20
NVS-MLLT-1
YEATS MLLT1, MLLT3 NVS-iMLLT-C No 03/20
NVS-PAK1-1
Kinase PAK1 NVS-PAK1-C No 06/16
OF-1
Bromodomains BRPF1, BRD1, BRPF3 No 07/14
Ogerin GPCR GPR68 ZINC32547799 Yes 06/20
OICR-9429
WD40 repeat WDR5 OICR-0547 No 05/14
PF-04418948 GPCR PTGER2 PF-04475866 Yes 05/18
PF-04457845 Hydrolase FAAH PF-04875474 Yes 05/18
PF-05105679 Ion channel TRPM8 PF-05257137 Yes 05/18
PFI-1
Bromodomains BRD2, BRD3, BRD4, BRDT No 11/11
PFI-2
Methyltransferase SETD7 (S)-PFI-2 No 05/13
PFI-3
Bromodomains SMARCA2, PBRM1, SMARCA4 PFI-3oMet No 11/13
PFI-4
Bromodomains BRPF1 No 12/14
PFI-5
Methyltransferase SMYD2 PFI-5N 07/17
PFI-6
YEATS MLLT1, MLLT3 PFI-6N No 06/20
PFI-653 Hydrolase VNN1 PFI-653-N Yes 09/21
PFI-7
E3 ligase GID4 PFI-7N No 09/21
PPTN GPCR P2RY14 PPTN-NC Yes 06/19
SGC-AAK1-1
Kinase AAK1, BMP2K, BIKE SGC-AAK1-1N 02/18
SGC-CAMKK2-1
Kinase CAMKK1, CAMKK2 SGC-CAMKK2-1N No 01/20
SGC-CBP30
Bromodomains CREBBP, EP300 BDOIA513 No 03/13
SGC-CK2-1
Kinase CSNK2A1, CSNK2A2 SGC-CK2-1N No 06/20
SGC-CLK-1
Kinase CLK1, CLK2, CLK4 SGC-CLK-1N No 02/20
SGC-GAK-1
Kinase GAK SGC-GAK-1N 02/18
SGC-SMARCA-BRDVIII
Bromodomains PB1(5), SMARCA2/4 SGC-BRDVIII-NC 12/20
SGC-STK17B-1
Kinase STK17B, DRAK2 SGC-STK17B-1N 02/20
SGC0946
Methyltransferase DOT1L SGC0649 No 08/12
SGC3027
Methyltransferase PRMT7 SGC3027N 03/18
SGC6870
Methyltransferase PRMT6 SGC6870N 06/19
SGC707
Methyltransferase PRMT3 XY1 No 06/14
Skepinone-L Kinase MAPK14 FM-743 Yes 01/20
SKI-73
Methyltransferase CARM1 SKI-73N 07/17
SR-302 Kinase DDR1, DDR2, MAPK11, MAPK14 SR-301 No 06/20
SR-318 Kinase MAPK14 SR-321 No 01/20
T-26c
Protease MMP13 T-26f 06/16
T-26c Protease MMP13 T-26f Yes 05/18
T3-CLK Kinase CLK1, CLK2, CLK3, CLK4 T3-CLK-N No 04/19
T3-CLK
Kinase CLK1, CLK2, CLK3, CLK4 T3-CLK-N No 05/19
TH-257
Kinase LIMK1, LIMK2 TH-263 07/17
THPP-1 Phosphodiesterase PDE10A THPP-1-NC Yes 06/19
TP-004 Protease METAP2 TPn-004 Yes 05/18
TP-008
Kinase ALK4, ALK5 AI11 No 05/19
TP-008 Kinase ACVR1B, TGFBR1 Al11 No 06/19
TP-020 Transferase MGAT2 TP-020n Yes 11/18
TP-021 Transcription factor BCL6 TP-021n Yes 11/18
TP-024 GPCR GPR52 TP-024n Yes 11/18
TP-030-1 Kinase RIPK1 TP-030n Yes 09/20
TP-030-2 Kinase RIPK1 TP-030n Yes 09/20
TP-040 Hydrolase OGA TP-040n Yes 09/21
TP-064
Methyltransferase CARM1 TP-064N 06/16
TP-238
Bromodomains CECR2, BPTF TP-422 09/18
TP-472
Bromodomains BRD9, BRD7 TP-472N Yes 06/16
UCSF924 GPCR DRD4 UCSF924NC Yes 04/19
UNC0638
Methyltransferase EHMT2/G9a, EHMT1/GLP UNC0737 No 06/10
UNC0642
Methyltransferase EHMT2/G9a, EHMT1/GLP Yes 08/12
UNC1215
Methyl Lysine Binder L3MBTL3 UNC1079 No 08/12
UNC1999
Methyltransferase EZH2 UNC2400 Yes 05/13
UNC6934
Methyl Lysine Binder NSD2-PWWP1 UNC7145 06/19
VinSpinIn
Spindlin domains Spin1 VinSpinIC 09/18
WM-1119 Transferase KAT6A, KAT6B WM-2474 Yes 06/20
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