Chemical Probes

Please select a protein family

( ( ( ASH1L:0.42656, ( SP100:0.36789, ( SP110:0.33224, ( SP140:0.13671, SP140L:0.10984) :0.20058) :0.03793) :0.06052) :0.01373, ( ( ( ATAD2:0.26940, ATAD2B:0.26369) :0.19033, ( ( ( ( ( BRD1:0.22380, BRPF3:0.22705) :0.01451, BRPF1:0.23801) :0.20719, ( ( ( ( ( ( BRD2:0.19557, BRD3:0.19148) :0.04050, BRD4:0.25182) :0.02415, BRDT:0.28925) :0.14057, PBRM1:0.44189) :0.00803, ( CREBBP:0.20246, EP300:0.20268) :0.23148) :0.00872, ( ( BRD7:0.33523, BRD9:0.32809) :0.08483, ( CECR2:0.43144, KIAA2026:0.43985) :0.00515) :0.00941) :0.00414) :0.00503, ( ( BRWD1:0.23336, ( BRWD3:0.23371, PHIP:0.22856) :0.00717) :0.20977, ( ZMYND11:0.36547, ZMYND8:0.37118) :0.07274) :0.01167) :0.00465, ( TAF1:0.04053, TAF1L:0.04161) :0.41155) :0.00158) :0.00393, BRD8:0.44351) :0.00285) :0.00187, ( ( ( BAZ1A:0.40491, BAZ1B:0.40021) :0.02117, ( BAZ2A:0.35523, BAZ2B:0.35501) :0.06222) :0.02521, ( MLL:0.41568, ( ( ( TRIM24:0.25638, TRIM33:0.25600) :0.09230, TRIM28:0.34971) :0.03714, TRIM66:0.38654) :0.04652) :0.01663) :0.00258, ( ( BPTF:0.42133, ( KAT2A:0.15500, KAT2B:0.14788) :0.26722) :0.02034, ( SMARCA2:0.11640, SMARCA4:0.11442) :0.33318) :0.00435);
( ( ( ( JARID2:0.43039, ( ( ( ( KDM4A/JMJD2A:0.23155, KDM4C/JMJD2C:0.23341) :0.01707, KDM4B/JMJD2B:0.24566) :0.01607, ( KDM4D/JMJD2D:0.16619, KDM4DL/JMJD2E:0.17175) :0.06332) :0.15741, ( ( KDM5A/JARID1A:0.23147, KDM5B/JARID1B:0.24003) :0.02678, ( KDM5C/JARID1C:0.06805, KDM5D/JARID1D:0.07750) :0.18760) :0.14048) :0.03729) :0.01341, ( MINA:0.35985, NO66/FLJ21802:0.34553) :0.09246) :0.00726, ( ( ( JHDM1D/KIAA1718:0.30283, ( PHF2:0.26273, PHF8:0.26463) :0.04507) :0.10219, ( KDM2A/FBXL11:0.24364, KDM2B/FBXL10:0.23571) :0.16985) :0.01908, JMJD6:0.41429) :0.03462) :0.00458, ( ( JMJD1C:0.30946, ( KDM3A/JMJD1A:0.26975, KDM3B/JMJD1B:0.25258) :0.06381) :0.12378, ( JMJD5:0.43831, ( ( KDM6A/UTX:0.06705, UTY:0.06732) :0.27041, KDM6B/JMJD3:0.33895) :0.11043) :0.01232) :0.00148, ( KDM1A/LSD1:0.38589, KDM1B/LSD2:0.38297) :0.08988);
( ( L3MBTL:0.26880, ( ( L3MBTL2:0.22568, MBTD1:0.22655) :0.17920, ( ( SCMH1:0.26354, SCML2:0.26828) :0.12779, ( SFMBT1:0.22793, SFMBT2:0.23512) :0.13803) :0.02634) :0.10947) :0.01818, L3MBTL3:0.27089, L3MBTL4:0.23794);
( ( ( ( ( ( ( ASH1L:0.41664, ( ( SETD3:0.41040, SETD4:0.41233) :0.00239, SETD6:0.41336) :0.04317) :0.00783, ( ( ( ( SMYD1:0.34933, SMYD3:0.34226) :0.00652, SMYD2:0.34805) :0.05781, SMYD4:0.40382) :0.01255, SMYD5:0.42036) :0.03407) :0.00364, ( ( ( ( CARM1:0.35324, ( PRMT2:0.33715, PRMT6:0.32951) :0.01450) :0.01142, ( ( PRMT1:0.11741, PRMT8:0.11805) :0.16780, PRMT3:0.29132) :0.07270) :0.06188, ( PRMT7:0.41262, PRMT9:0.40675) :0.01709) :0.03029, PRMT5:0.44807) :0.01398) :0.00463, ( ( ( ( CAMKMT:0.42587, EEF2KMT:0.42552) :0.00950, ( ( METTL21A:0.35150, METTL21D:0.34116) :0.03059, METTL21C:0.37356) :0.05156) :0.00986, SETD2:0.41629) :0.01686, ( ( ( ( ( ( EHMT1/GLP:0.26312, EHMT2/G9A:0.26663) :0.10422, ( SUV39H1:0.20671, SUV39H2:0.20548) :0.16629) :0.02669, ( SETDB1:0.34392, SETDB2:0.35705) :0.06209) :0.01897, SETMAR:0.43380) :0.00575, ( NSD1:0.28947, ( WHSC1:0.28335, WHSC1L1:0.28588) :0.02046) :0.12647) :0.01053, ( ( ( EZH1:0.17720, EZH2:0.17535) :0.24657, SETD7:0.43372) :0.01694, ( ( MLL:0.31117, MLL4:0.31609) :0.05423, SETD8:0.39677) :0.03148) :0.00684) :0.00558) :0.00421) :0.00550, ( ( ( ( MECOM:0.23499, PRDM16:0.22172) :0.19790, ( PRDM13:0.40625, PRDM8:0.41523) :0.01377) :0.01047, ( METTL20:0.41561, PRDM2:0.40118) :0.02407) :0.00891, ( ( ( PRDM1:0.41095, ( ( ( PRDM12:0.34755, PRDM6:0.35817) :0.02348, PRDM14:0.38137) :0.01014, PRDM4:0.40304) :0.01522) :0.00630, ( ( PRDM15:0.36547, PRDM5:0.38056) :0.03066, ( PRDM7:0.13090, PRDM9:0.11910) :0.29272) :0.00897) :0.00944, ( PRDM10:0.41440, PRDM11:0.41339) :0.00558) :0.02345) :0.00880) :0.00378, ( MLL5:0.34249, SETD5:0.34753) :0.10101) :0.00319, ( DOT1L:0.43970, ( ( FBL:0.43564, ( PCMT1:0.41513, ( SETD1A:0.30089, SETD1B:0.30309) :0.09786) :0.01938) :0.00301, ( MLL2:0.34090, MLL3:0.34348) :0.05345) :0.01186) :0.00212, ( SUV420H1:0.28698, SUV420H2:0.27795) :0.16293);
( ( SPIN1:0.05966, SPIN3:0.09538) :0.01442, ( SPIN2A:0.00390, SPIN2B:0.00000) :0.15225, SPIN4:0.19320);
( ( ( ( ( ( ( ( ( ( ( ( ( A6NM71:0.19599, WDR45:0.20470) :0.09963, WDR45B:0.29608) :0.08691, ( WIPI1:0.23323, WIPI2:0.23314) :0.16096) :0.05462, ( HPS5:0.42495, ( Q6ZS54:0.07930, TECPR2:0.06531) :0.34740) :0.02830) :0.00738, ( ( ( ( ( B3KP68:0.02958, IFT172:0.01983) :0.40428, ( H3BRJ5:0.08519, IFT80:0.08212) :0.34677) :0.01950, ( ( ( ( B4DGB7:0.10634, ( FLJ00025:0.01620, IFT122:0.01417) :0.08590) :0.33152, ( B4E286:0.00099, WDR19:-0.00021) :0.43697) :0.00625, ( B4DX09:0.00715, WDR11:-0.00715) :0.43568) :0.00117, WDR35:0.44480) :0.00621) :0.00259, ( NOL10:0.43979, ( WDR4:0.40993, WDR87:0.39832) :0.01255) :0.01757) :0.00463, ( ( C2ORF44:0.45495, ( RIC1:0.42645, WDPCP:0.44085) :0.01431) :0.01021, ( ( CFAP43:0.40442, WRAP73:0.39775) :0.03042, ( ( CIRH1A:0.01057, UTP4:-0.01057) :0.26437, UTP4B:0.22739) :0.15541) :0.01526) :0.00324) :0.00174) :0.00345, ( ( ( ( ( ARPC1A:0.15819, ARPC1B:0.15532) :0.26205, TULP4:0.42618) :0.01479, ( B4DT22:0.02871, PPWD1:0.02811) :0.42170) :0.00791, ( ( CHAF1B:0.38203, HIRA:0.38363) :0.04882, TBL2:0.42406) :0.01183) :0.00567, ( ( ( ( ( B4E018:0.06432, WDR74:0.07068) :0.34127, TBC1D31:0.43230) :0.01525, ( CFAP57:0.41726, WDR43:0.42173) :0.02215) :0.00643, ( ( IFT140:0.41881, PAK1IP1:0.40262) :0.01842, NEDD1:0.43401) :0.01328) :0.00169, ( ( ( Q9H8N9:0.00036, WDFY1:-0.00036) :0.19830, WDFY2:0.19595) :0.22661, WDR75:0.43841) :0.01209) :0.00368) :0.00262) :0.00142, ( ( ( ( ( ( B3KXN4:0.00113, WDR1:0.00063) :0.20232, B4DZX5:0.20358) :0.19099, NUP214:0.41605) :0.02208, ( B4E3M9:0.05032, BCAS3:0.04158) :0.40645) :0.01139, ( ( LYST:0.39074, WDR73:0.41613) :0.01794, WDR70:0.42844) :0.01302) :0.00482, ( ( ( ( B4DGE3:-0.00339, SEC31B:0.01476) :0.21084, SEC31A:0.22467) :0.20565, ( ( ( ( ( ( ( B4DMH3:0.00480, CORO1C:-0.00252) :0.15714, ( CORO1B:0.07346, Q59F81:0.04849) :0.07712) :0.01779, CORO6:0.16560) :0.00886, CORO1A:0.17512) :0.10337, ( CORO2A:0.17112, CORO2B:0.17054) :0.11519) :0.08192, CORO7:0.35399) :0.00600, Q6ZW98:0.35243) :0.05427) :0.01648, ( ( DMWD:0.20530, WDR20:0.20771) :0.22659, EDC4:0.43492) :0.01149) :0.00762) :0.00284) :0.00084, ( ( ( ( ( B3KP80:0.00256, KCTD3:-0.00040) :0.20355, SHKBP1:0.20559) :0.24354, ( ( LLGL1:0.22912, LLGL2:0.22970) :0.14773, ( STXBP5L:0.17197, STXBP5:0.16774) :0.20385) :0.06098) :0.00826, ( PAN2:0.44184, WDR53:0.40732) :0.01742) :0.00659, ( ( FBXW12:0.44201, WDR91:0.42868) :0.01595, ( WDR72:0.34853, WDR7:0.33569) :0.09711) :0.00847) :0.00188) :0.00094, ( ( ( ( DDB2:0.41348, WDR64:0.41790) :0.02504, ( EIF2A:0.42370, EIF3B:0.42416) :0.03594) :0.00269, ( ( NBAS:0.39925, PREB:0.41130) :0.03107, ( Q8N7X6:0.35163, WDR49:0.33563) :0.09867) :0.01070) :0.00192, ( ( ( ( ( PPP2R2A:0.06095, PPP2R2D:0.05986) :0.02793, ( PPP2R2B:0.06394, PPP2R2C:0.06473) :0.02365) :0.10439, Q59GC6:0.19117) :0.11725, Q6ZP32:0.32295) :0.13007, ( Q8N797:0.11339, WDR17:0.12507) :0.29318) :0.01686) :0.00252) :0.00185, ( ( ( ( AMBRA1:0.42291, ( B4E068:0.18682, WRAP53:0.19616) :0.21323) :0.02271, ( ( ( ( ( B3KUA2:0.00923, TLE3:0.00937) :0.09175, ( ( B4DEF9:0.00629, ( B4E345:0.00247, TLE1:-0.00247) :0.00846) :0.05931, TLE4:0.06588) :0.03599) :0.05206, ( B4DE62:0.03566, TLE2:0.04726) :0.10225) :0.17653, Q59EY9:0.33100) :0.09577, RFWD3:0.44119) :0.00962) :0.00837, ( ( ( ( B3KVI6:0.01383, LRBA:-0.01062) :0.15720, NBEA:0.14845) :0.21809, ( ( ( B4DVX0:0.01445, NBEAL2:-0.01445) :0.22279, NBEAL1:0.22376) :0.14282, NSMAF:0.37265) :0.00570) :0.05341, ( ( WDF3:0.04066, WDFY3:0.01411) :0.33624, WDFY4:0.35214) :0.05767) :0.01384) :0.00290, ( ( ( B7Z6H0:0.00262, SCAP:0.00031) :0.40861, WDR54:0.40729) :0.02915, ( MIOS:0.43207, THOC6:0.39784) :0.02348) :0.00730) :0.00379) :0.00107, ( ( ( ( B4DDD4:0.07776, WDR27:0.08246) :0.34083, ( FBXW4:0.41335, FBXW8:0.42160) :0.01194) :0.01445, ( VPRBP:0.43447, WDR37:0.41978) :0.01648) :0.00551, ( ( ( ( ( ( ( B4DN30:0.05743, DCAF4:0.05227) :0.06312, DCAF4L1:0.11562) :0.01435, DCAF4L2:0.12771) :0.30738, NWD2:0.42207) :0.01402, ( ( DMXL1:0.21995, DMXL2:0.22669) :0.16977, WDR92:0.40662) :0.03040) :0.00562, ( ( FBXW5:0.43540, ( FBXW9:0.40893, WDR81:0.40050) :0.01014) :0.01788, ( LRRK2:0.41772, MED16:0.44545) :0.01573) :0.00671) :0.00053, ( ( DCAF12L1:0.06676, DCAF12L2:0.06499) :0.11804, DCAF12:0.19026) :0.26659) :0.00373) :0.00089) :0.00136, ( ( ( ( ( AAMP:0.40151, ( ( DKFZP779C159:0.00283, KIF21A:0.00177) :0.22040, KIF21B:0.22176) :0.19539) :0.01372, WDR46:0.44082) :0.00864, ( RRP9:0.40700, WDR66:0.42458) :0.02017) :0.00541, ( ( ( B3KRR8:0.00369, WDR6:-0.00075) :0.23320, B4DK45:0.23445) :0.19837, ( GTF3C2:0.43690, ( HERC1:0.37630, NUP43:0.41054) :0.01224) :0.00945) :0.00794) :0.00125, ( CFAP44:0.41208, DCAF7:0.40955) :0.03312) :0.00392) :0.00045, ( ( ( ( ( ( ( ( ( ( ( ( A6P4T4:0.00508, EML4-ALK:-0.00131) :0.00549, B6EXY3:0.00431) :0.00673, A6P4V4:-0.00608) :0.16334, EML4:0.15948) :0.11014, ( ( B3KXA3:0.00255, EML1:0.00113) :0.19920, ( ( B7Z2F5:0.03845, EML2:0.03859) :0.07400, ( B7Z872:0.09969, B7Z918:0.09988) :0.02044) :0.08517) :0.07339) :0.02170, ( B4DL97:0.05251, EML3:0.05016) :0.23941) :0.12143, ( ( EML5:0.12612, EML6:0.12516) :0.24748, THOC3:0.37474) :0.01937) :0.02300, ( ( ( ( ( B4E1H5:-0.00073, CDC20:0.00073) :0.04208, Q2VIM1:0.04564) :0.27443, FZR1:0.32015) :0.03459, CDC20B:0.36376) :0.06893, ( B4E383:0.05144, ERCC8:0.05236) :0.36590) :0.01070) :0.00439, ( ( ( ( B4E2R3:0.09408, MLST8:0.11371) :0.27792, ELP2:0.41424) :0.01052, PRPF4:0.41017) :0.01458, ( BUB3:0.32893, RAE1:0.33876) :0.09452) :0.00675) :0.00252, ( ( ( ( ( B3KMW5:0.00404, WDR3:-0.00404) :0.42113, ( ( EIF3I:0.38888, STRAP:0.38651) :0.00967, UTP15:0.41483) :0.01348) :0.00625, ( ( ( GEMIN5:0.38483, WDR61:0.35287) :0.02545, WDSUB1:0.41275) :0.00266, ( TBL3:0.39295, ( WDR38:0.33694, WDR86:0.36688) :0.01314) :0.01698) :0.01064) :0.00548, ( ( ( B4DYK8:0.04841, WDR97:0.05199) :0.36562, ( PWP2:0.20216, Q59FM2:0.17758) :0.21800) :0.00823, ( WSB1:0.25729, WSB2:0.25756) :0.15581) :0.00778) :0.00546, ( ( ( CFAP52:0.40760, ( MAPKBP1:0.31335, WDR62:0.31281) :0.08255) :0.03133, ( WDR18:0.40917, WDR36:0.41258) :0.02506) :0.00504, ( DCAF13:0.42565, ( GNB1L:0.38044, NWD1:0.39632) :0.02210) :0.01611) :0.00258) :0.00317) :0.00112, ( ( ( ( ( ( ( ( A8MWR8:0.09797, SEC13:0.12883) :0.22721, SEH1L:0.36857) :0.05121, ( RBBP5:0.41351, WDR33:0.40991) :0.01392) :0.00833, ( ( B4E0E6:0.00291, DTL:0.00291) :0.41190, DCAF5:0.42079) :0.01470) :0.00503, ( KATNB1:0.41545, ( NUP37:0.40160, WDHD1:0.41128) :0.01968) :0.01110) :0.00528, ( ( ( B4DTI1:-0.01954, GRWD1:0.02486) :0.37746, ( RBBP4:0.06355, RBBP7:0.06351) :0.33629) :0.02019, ( BRWD1:0.23583, ( BRWD3:0.23125, PHIP:0.23102) :0.00470) :0.17900) :0.01180) :0.00482, ( ( ( B4DVM5:0.05661, WDR24:0.05885) :0.36345, PEX7:0.38687) :0.01489, ( DPH7:0.41974, WDR59:0.41654) :0.02361) :0.01021) :0.00438, ( ( ( ( ( ( B4DVD2:0.07277, GNB2L1:0.08107) :0.15670, B4DWC6:0.23201) :0.13491, WDR48:0.42071) :0.01251, ( ( ( COPA:0.39101, COPB2:0.39155) :0.02132, ( ( POC1A:0.20608, POC1B:0.21652) :0.11242, Q6ZW40:0.32744) :0.05323) :0.01827, PLAA:0.43715) :0.00375) :0.00749, ( WDR31:0.41330, WDR41:0.43138) :0.00923) :0.00689, ( ( ( CDRT1:0.06079, FBXW10:0.05756) :0.16337, Q59EB2:0.22408) :0.19781, TSSC1:0.41803) :0.02706) :0.00381) :0.00246) :0.00127, ( ( ( ( AAAS:0.00368, B4DDU7:0.00217) :0.43512, ( WDR77:0.38904, WDR90:0.37704) :0.02197) :0.01143, ( ( B4DVQ7:0.07250, WDR13:0.09771) :0.32295, DCAF10:0.42018) :0.02014) :0.00519, ( ( BOP1:0.42861, ( CDC40:0.40982, WDR25:0.41555) :0.01395) :0.01001, ( ( ( DCAF11:0.07938, Q59GN6:0.07627) :0.24148, H0YL77:0.33441) :0.09089, RPTOR:0.42585) :0.02229) :0.00618) :0.00430) :0.00076, ( ( ( ( ( ( ( AHI1:0.40130, WDR82:0.37506) :0.03193, ( ( ( B7Z2P6:0.00203, DCAF8:-0.00036) :0.15904, ( DCAF8L1:0.09869, DCAF8L2:0.09965) :0.06455) :0.23254, ( DCAF6:0.39601, WDTC1:0.39276) :0.00502) :0.04073) :0.00164, ( WDR44:0.40029, WDR83:0.35527) :0.03242) :0.01161, ( ( B4DNL1:-0.00363, PWP1:0.00363) :0.42075, LRWD1:0.44242) :0.01277) :0.00198, ( ( EED:0.42523, WDR76:0.43871) :0.00562, ( PALB2:0.43169, WDR89:0.42102) :0.01464) :0.01355) :0.00171, ( ( ( ( ( ( B4DPZ3:0.01412, DYNC1I2:0.01445) :0.00174, B4DX93:0.00613) :0.08999, DYNC1I1:0.10865) :0.30047, ( ( DNAI1:0.37465, WDR78:0.37357) :0.03257, WDR34:0.39929) :0.00653) :0.01937, ( DNAI2:0.37957, WDR63:0.39068) :0.04467) :0.01932, ( ( Q9Y6S1:0.03059, TLE6:0.03453) :0.37107, WDR60:0.41536) :0.03766) :0.00595) :0.00426, ( ( ( ( ( ( ( ( ( ( APAF1:0.38443, DAW1:0.36738) :0.01812, CSTF1:0.41112) :0.01287, ( ( ( DKFZP434D199:0.07977, SNRNP40:0.09346) :0.27479, WDR26:0.41317) :0.01004, ( ( PAFAH1B1:0.36051, ( WDR5B:0.07428, WDR5:0.07421) :0.26255) :0.01033, SMU1:0.39458) :0.02006) :0.00695) :0.00182, WDR88:0.41658) :0.00436, ( ( ( ( B4E074:0.00110, NLE1:0.00107) :0.00847, B4E303:0.01076) :0.38001, ( ( ( ( ( GNB1:0.04553, GNB4:0.04565) :0.00324, GNB2:0.04970) :0.04388, GNB3:0.09509) :0.14002, GNB5:0.24491) :0.13609, SPAG16:0.39576) :0.01277) :0.00607, WDR47:0.42413) :0.01224) :0.00333, ( ( ( ( BTRC:0.08136, FBXW11:0.07915) :0.29724, ( FBXW7:0.06995, Q53F40:0.07040) :0.30417) :0.02436, FBXW2:0.40974) :0.02740, ( PIK3R4:0.41642, WDR12:0.39446) :0.02518) :0.00374) :0.00073, ( ( DKFZP451A177:0.00547, ZNF106:-0.00304) :0.42524, TRAF7:0.42429) :0.01771) :0.00158, ( ( ( ( ( B7Z475:-0.00641, TBL1XR1:0.00641) :0.06013, ( TBL1X:0.04446, TBL1Y:0.04175) :0.02600) :0.32034, CIAO1:0.36726) :0.02291, ( ( STRN3:0.18112, STRN:0.18299) :0.05937, STRN4:0.23401) :0.18763) :0.00531, ( PLRG1:0.41162, ( PRPF19:0.40837, ( TAF5L:0.30796, TAF5:0.30834) :0.09896) :0.00834) :0.00738) :0.00813) :0.00255, ( ( ( ( ATG16L1:0.00344, Q9NWG8:0.01275) :0.25871, Q8TCI4:0.23490) :0.11177, ( ATG16L2:0.18566, FLJ00012:0.16049) :0.19150) :0.05598, ( ( Q59EZ2:0.00688, TEP1:0.00047) :0.37045, WDR55:0.39349) :0.02789) :0.00450) :0.00338, ( ( DENND3:0.43279, UTP18:0.42873) :0.01247, ( PAAF1:0.40268, RFWD2:0.41875) :0.01927) :0.01205) :0.00286) :0.00102);
((MLLT1:0.23658,MLLT3:0.23569):0.22518,YEATS2:0.36660,YEATS4:0.35586);

Chemical Probes

Potent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories.

Donated probe website KCGS website

SGC chemical probes are open-access reagents that are meant to be used by  the biomedical research community with no restrictions on use. To acquire a sample, follow the links on the webpage of your desired chemical probe. You can sort the table by clicking the column headers.

The SGC probes set is complemented by the donated probe set

Name Structures Protein family Specific Targets Control In Vivo Activity* Addedsort descending
JQ1
 		Bromodomains BRD2, BRD3, BRD4, BRDT (-)-JQ1 Yes 06/10
UNC0638
 		Methyltransferase EHMT2/G9a, EHMT1/GLP UNC0737 No 06/10
PFI-1
 		Bromodomains BRD2, BRD3, BRD4, BRDT No 11/11
IOX1
(tool compound)
 		2OG Pan-KDM No 01/12
IOX2
(requires >>> 1 microM for cell assays)
 		2OG PHD2 No 02/12
GSK-J1
use pro-drug GSK-J4 for cell assays
 		Lysine Demethylase KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B GSK-J2 (GSK-J5) No 07/12
GSK343
 		Methyltransferase EZH2 No 08/12
UNC0642
 		Methyltransferase EHMT2/G9a, EHMT1/GLP Yes 08/12
SGC0946
 		Methyltransferase DOT1L SGC0649 No 08/12
UNC1215
 		Methyl Lysine Binder L3MBTL3 UNC1079 No 08/12
Bromosporine (BSP)
(tool compound)
 		Bromodomains pan-Bromodomain No 01/13
I-CBP112
 		Bromodomains CREBBP, EP300 No 03/13
SGC-CBP30
 		Bromodomains CREBBP, EP300 BDOIA513 No 03/13
PFI-2
 		Methyltransferase SETD7 (S)-PFI-2 No 05/13
UNC1999
 		Methyltransferase EZH2 UNC2400 Yes 05/13
A-366
 		Methyltransferase EHMT1/GLP, EHMT2/G9a No 06/13
PFI-3
 		Bromodomains SMARCA2, PBRM1, SMARCA4 PFI-3oMet No 11/13
LLY-507
(Multiple Off-target Effects)
 		Methyltransferase SMYD2 SGC705 No 11/13
GSK-LSD1
 		Lysine Demethylase KDM1A/LSD1 No 03/14
OICR-9429
 		WD40 repeat WDR5 OICR-0547 No 05/14
BAZ2-ICR
 		Bromodomains BAZ2A, BAZ2B Yes 05/14
SGC707
 		Methyltransferase PRMT3 XY1 No 06/14
OF-1
 		Bromodomains BRPF1, BRD1, BRPF3 No 07/14
PFI-4
 		Bromodomains BRPF1 No 12/14
NI-57
 		Bromodomains BRPF1, BRD1, BRPF3 No 12/14
LP99
 		Bromodomains BRD9, BRD7 2S,3R-enantiomer No 12/14
GSK2801
 		Bromodomains BAZ2A, BAZ2B GSK8573 Yes 12/14
GSK484
 		Arginine deiminases PAD4 GSK106 Yes 03/15
BAY-598
 		Methyltransferase SMYD2 BAY-369 Yes 04/15
BI-9564
 		Bromodomains BRD9, BRD7 Yes 04/15
I-BRD9
 		Bromodomains BRD9 No 05/15
NVS-CECR2-1
 		Bromodomains CECR2 NVS-CECR2-C No 06/15
MS049
 		Methyltransferase CARM1, PRMT6 MS049N No 06/15
MS023
 		Methyltransferase PRMT1, PRMT3, CARM1, PRMT6, PRMT8 MS094 No 07/15
GSK591
 		Methyltransferase PRMT5 SGC2096 No 07/15
A-196
 		Methyltransferase SUV420H1, SUV420H2 A-197, SGC2043 No 07/15
BAY-678
 		Protease ELANE BAY-677 Yes 10/15
GSK864
 		Dehydrogenase IDH1 GSK990 Yes 11/15
NVS-PAK1-1
 		Kinase PAK1 NVS-PAK1-C No 06/16
BAY-299
 		Bromodomains TAF1, BRD1 BAY-364 No 06/16
T-26c
 		Protease MMP13 T-26f 06/16
TP-064
 		Methyltransferase CARM1 TP-064N 06/16
TP-472
 		Bromodomains BRD9, BRD7 TP-472N Yes 06/16
A-395
 		WD40 repeat EED A-395N 07/16
LLY-283
 		Methyltransferase PRMT5 LLY-284 07/16
GSK6853
 		Bromodomains BRPF1 GSK9311 Yes 01/17
GSK8814
 		Bromodomains ATAD2, ATAD2B GSK8815 01/17
BAY-850
 		Bromodomains ATAD2 BAY-460 01/17
FM-381
 		Kinase JAK3 FM-479 02/17
GSK4027
 		Bromodomains KAT2A, KAT2B GSK4028 06/17
BAY-6035
 		Methyltransferase SMYD3 BAY-444 06/17
PFI-5
 		Methyltransferase SMYD2 PFI-5N 07/17
SKI-73
 		Methyltransferase CARM1 SKI-73N 07/17
TH-257
 		Kinase LIMK1, LIMK2 TH-263 07/17
L-Moses
 		Bromodomains KAT2A, KAT2B D-Moses Yes 10/17
A-485
 		Lysine acetyltransferase CREBBP, EP300 A-486 10/17
BI01383298
 		Solute carriers SLC13A5 BI01372674 01/18
SGC-AAK1-1
 		Kinase AAK1, BMP2K, BIKE SGC-AAK1-1N 02/18
SGC-GAK-1
 		Kinase GAK SGC-GAK-1N 02/18
SGC3027
 		Methyltransferase PRMT7 SGC3027N 03/18
BAY-474 Kinase MET BAY-827 Yes 05/18
BI 99179 Synthase FASN BI 99990 No 05/18
BAY-7598 Protease MMP12 BAY-694 Yes 05/18
ERKi Kinase MAPK3, MAPK1 ERKi-NC Yes 05/18
ABT-724 GPCR DRD4 A-769 Yes 05/18
BI 665915 Lipoxygenase ALOX5AP BI-0153 Yes 05/18
BAY-826 Kinase TIE1, TEK, DDR1, DDR2 BAY-309 Yes 05/18
CRTH2 antagonist GPCR PTGDR2 CRTH2 negative control Yes 05/18
MRL-650 GPCR CNR1 MRL-CB1-NC Yes 05/18
MRL-SYKi Kinase SYK MRL-SYKi-NC Yes 05/18
MRK-560 Protease Gamma secretase complex GSI-NC Yes 05/18
GSM1 Protease Gamma secretase complex GSM-NC Yes 05/18
BI-1935 Hydrolase EPHX2 BI-2049 Yes 05/18
PF-04418948 GPCR PTGER2 PF-04475866 Yes 05/18
PF-05105679 Ion channel TRPM8 PF-05257137 Yes 05/18
TP-004 Protease METAP2 TPn-004 Yes 05/18
BI-9627 Solute carriers SLC9A1 BI-0054 Yes 05/18
A-485 Transferase EP300, CREBBP A-486 Yes 05/18
BAY-707 Hydrolase NUDT1 BAY-604 Yes 05/18
BAY-386 GPCR F2R BAY-448 Yes 05/18
BTZO-1 Cytokine MIF BTZO-4 No 05/18
ABT-100 Transferase FNTB A-108 Yes 05/18
(R)-9s GPCR ADRA1D (S)-9s Yes 05/18
KISS1-305 GPCR KISS1R KISS1-543 Yes 05/18
PF-04457845 Hydrolase FAAH PF-04875474 Yes 05/18
ABT-546 GPCR EDNRA A-545 Yes 05/18
T-26c Protease MMP13 T-26f Yes 05/18
BAY-876 Solute carriers SLC2A1 BAY-588 Yes 05/18
BAY-678 Protease ELANE BAY-677 Yes 05/18
MRK-740
 		Methyltransferase PRDM9 MRK-740-NC 06/18
BI-9321
 		Methyl Lysine Binder NSD3 BI-9466 07/18
DDR-TRK-1
 		Kinase DDR, TRK DDR-TRK-1N Yes 08/18
TP-238
 		Bromodomains CECR2, BPTF TP-422 09/18
VinSpinIn
 		Spindlin domains Spin1 VinSpinIC 09/18
A-079 Ion channel TRPA1 A-226 Yes 11/18
BI-4394 Protease MMP13 BI-4395 Yes 11/18
BAY-885 Kinase MAPK7 BAY-693 No 11/18
BI-2545 Phosphodiesterase ENPP2 BI-3017 Yes 11/18
BI 639667 GPCR CCR1 BI-9307 Yes 11/18
BI 653048 Nuclear hormone receptor NR3C1 BI-3047 Yes 11/18
BI-1950 Integrin ITGAL BI-9446 Yes 11/18
BAY-1797 Ion channel P2X4 BAY-207 Yes 11/18
BAY-784 GPCR GNRHR BAY-786 Yes 11/18
TP-020 Transferase MGAT2 TP-020n Yes 11/18
TP-021 Transcription factor BCL6 TP-021n Yes 11/18
TP-024 GPCR GPR52 TP-024n Yes 11/18
NVS-BPTF-1
 		Bromodomains BPTF NVS-BPTF-C No 02/19
BI-1230 Protease HCV NS3 BI-1675 Yes 03/19
A-192621 GPCR EDNRB A-1806262 Yes 03/19
BAY-293 Nucleotide exchange factor SOS1 BAY-294 No 04/19
T3-CLK Kinase CLK1, CLK2, CLK3, CLK4 T3-CLK-N No 04/19
UCSF924 GPCR DRD4 UCSF924NC Yes 04/19
TP-008
 		Kinase ALK4, ALK5 AI11 No 05/19
T3-CLK
 		Kinase CLK1, CLK2, CLK3, CLK4 T3-CLK-N No 05/19
MU1210
 		Kinase CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 MU140 No 05/19
MLi-2 Kinase LRRK2 MLi-2-NC Yes 05/19
TP-008 Kinase ACVR1B, TGFBR1 Al11 No 06/19
BAY-549 Kinase ROCK1, ROCK2 BAY-4900 Yes 06/19
PPTN GPCR P2RY14 PPTN-NC Yes 06/19
THPP-1 Phosphodiesterase PDE10A THPP-1-NC Yes 06/19
MSD-CYP11B2 Cytochrome P450 CYP11B2 MSD-CYP11B2 Negative control Yes 06/19
UNC6934
 		Methyl Lysine Binder NSD2-PWWP1 UNC7145 06/19
SGC6870
 		Methyltransferase PRMT6 SGC6870N 06/19
A-1596586 Ion channel CFTR A-1596584 No 06/19
MSD-M1PAM GPCR CHRM1 MSD-M1PAM-NC Yes 08/19
IPP/CNRS-A017 Dehydrogenase DHODH IPP/CNRS-A019 No 10/19
A-1211212 Regulator protein BCL2 A-1210227 Yes 11/19
A-1155463 Regulator protein BCL2L1 A-1107969 Yes 11/19
BAY-985 Kinase TBK1, IKBKE BAY-440 Yes 01/20
BAY-899 GPCR LHCGR BAY-897 Yes 01/20
BAY-179 Complex I BAY-070 Yes 01/20
SR-318 Kinase MAPK14 SR-321 No 01/20
Skepinone-L Kinase MAPK14 FM-743 Yes 01/20
FS-694 Kinase MAPK14 FM-743 No 01/20
BAY-3827 Kinase PRKAA1, RPS6KA1 BAY-974 No 01/20
SGC-CAMKK2-1
 		Kinase CAMKK1, CAMKK2 SGC-CAMKK2-1N No 01/20
SGC-CLK-1
 		Kinase CLK1, CLK2, CLK4 SGC-CLK-1N No 02/20
SGC-STK17B-1
 		Kinase STK17B, DRAK2 SGC-STK17B-1N 02/20
NVS-MALT1 Protease MALT1 NVS-MALT1-C Yes 02/20
NVS-MLLT-1
 		YEATS MLLT1, MLLT3 NVS-iMLLT-C No 03/20
SGC-CK2-1
 		Kinase CSNK2A1, CSNK2A2 SGC-CK2-1N No 06/20
SR-302 Kinase DDR1, DDR2, MAPK11, MAPK14 SR-301 No 06/20
WM-1119 Transferase KAT6A, KAT6B WM-2474 Yes 06/20
Ogerin GPCR GPR68 ZINC32547799 Yes 06/20
(R)-ZINC-3573 GPCR MRGPRX2 (S)-ZINC-3573 No 06/20
PFI-6
 		YEATS MLLT1, MLLT3 PFI-6N No 06/20
NR162
 		Kinase CASK NR187 No 09/20
TP-030-1 Kinase RIPK1 TP-030n Yes 09/20
TP-030-2 Kinase RIPK1 TP-030n Yes 09/20
BAY-069 Amino acid transaminase BCAT1, BCAT2 BAY-771 Yes 09/20
BAY-390 Ion channel TRAP1 BAY-9897 Yes 09/20
BI-2540 Reverse transcriptase HIV NNRT BI-2439 Yes 11/20
BI 207127 RNA polymerase HCV NS5B BI-7656 Yes 11/20
BAY-6672 GPCR PTGFR BAY-403 Yes 11/20
SGC-SMARCA-BRDVIII
 		Bromodomains PB1(5), SMARCA2/4 SGC-BRDVIII-NC 12/20
BAY-3153 GPCR CCR1 BAY-173 Yes 02/21
GSK778 Bromodomains BRD2, BRD3, BRD4, BRDT Yes 02/21
GSK789 Bromodomains BRD2, BRD3, BRD4, BRDT GSK791 No 02/21
GSK046 Bromodomains BRD2, BRD3, BRD4, BRDT Yes 02/21
GSK620 Bromodomains BRD2, BRD3, BRD4, BRDT Yes 02/21
GSK973 Bromodomains BRD2, BRD3, BRD4, BRDT GSK943 Yes 02/21
* Data includes at least one of PK, clearance, etc.
glqxz9283 sfy39587stf02 mnesdcuix8
sfy39587stf03