Chemical Probes

SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. SGC-developed probes are complemented by a growing set of donated high-quality chemical probes developed in industry and non-SGC laboratories. These are also available for unencumbered use.

The table below contains the entire collection of probes from SGC’s chemical probes program and donated chemical probes. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers.

For inquiries or requests related to chemical probes or libraries, please contact us at proberequests@thesgc.org.

Add Filter
  • Probes
  • Protein
Name Structures Protein Family Target Protein Negative Control Cellular usage Added
JNJ-8003 RNA polymerase RSV-L JNJ-6643
JNJ-78911118 Glutamate-gated ion channel GRIN2A JNJ-77914993 up to 10 µM
ACBI3 GTPase KRAS cis-ACBI3 1-10 µM
THNAN69 Kinase LIMK2 THNAN69-NC 10 -100 nM
SM311 Kinase LIMK1 SM311-NC 0.1 - 1 µM
BI-5121 GPCR HCRTR1 BI-6199 100 nM
BAY-439 Phospholipase A2 PLA2G5 BAY-163 up to 300 nM
SGC-NSP2hel-1 Helicases CHIKV_nsp2 helicase SGC-NSP2hel-1N 1 µM
JYQ-173 Peptidase C56 PARK7 MB078 Up to 1 µM
Huib32 Deubiquitinase USP32 Huib32NC 5 µM
JNJ-79883960 Receptor NRLP3 JNJ-78832000 up to 10 µM
SGC-NSP2PRO-1 Protease CHIKV_nsp2 SGC-NSP2PRO-1N
LH168 WD40 repeat WDR5 LH222 1 µM
OICR-41103 WD40 repeat DCAF1 OICR-41103N 1 µM; not to exceed 5 µM
BI-1915 Protease CTSS BI-1920 1 µM
BI-113823 GPCR BDKRB1 BI-5832 100 nM
JNJ-54082730 Hydrolase PDE2A JNJ-54103985 1 µM
JNJ-3738 Kinase CDK7 JNJ-6240 1 µM
BAY-9835 Protease ADAMTS7, ADAMTS12 BAY-1880 100 nM
SGC-CDKL2/AAK1/BMP2K-1 Kinase CDKL2 CDKL2/AAK1/BMP2K -1N ≤1 µM
ABT-724 GPCR DRD4 A-769
ERKi Kinase MAPK3, MAPK1 ERKi-NC
BAY-7598 Protease MMP12 BAY-694
BI 99179 Synthase FASN BI 99990
BAY-474 Kinase MET BAY-827
(R)-9s GPCR ADRA1D (S)-9s
ABT-100 Transferase FNTB A-108
BTZO-1 Cytokine MIF BTZO-4
BAY-386 GPCR F2R BAY-448
BAY-707 Hydrolase NUDT1 BAY-604
A-485 Transferase EP300, CREBBP A-486
BI-9627 Solute carriers SLC9A1 BI-0054
TP-004 Protease METAP2 TPn-004
PF-05105679 Ion channel TRPM8 PF-05257137
PF-04418948 GPCR PTGER2 PF-04475866
BI-1935 Hydrolase EPHX2 BI-2049
GSM1 Protease Gamma secretase complex GSM-NC
MRK-560 Protease Gamma secretase complex GSI-NC
MRL-SYKi Kinase SYK MRL-SYKi-NC
MRL-650 GPCR CNR1 MRL-CB1-NC
CRTH2 antagonist GPCR PTGDR2 CRTH2 negative control
TP-021 Transcription factor BCL6 TP-021n
TP-020 Transferase MGAT2 TP-020n
BAY-784 GPCR GNRHR BAY-786
BAY-1797 Ion channel P2X4 BAY-207
BI-1950 Integrin ITGAL BI-9446
BI 653048 Nuclear hormone receptor NR3C1 BI-3047
BI 639667 GPCR CCR1 BI-9307
BI-2545 Phosphodiesterase ENPP2 BI-3017
BAY-885 Kinase MAPK7 BAY-693
BI-4394 Protease MMP13 BI-4395
A-079 Ion channel TRPA1 A-226
BAY-678 Protease ELANE BAY-677
BAY-876 Solute carriers SLC2A1 BAY-588
T-26c Protease MMP13 T-26f
ABT-546 GPCR EDNRA A-545
PF-04457845 Hydrolase FAAH PF-04875474
KISS1-305 GPCR KISS1R KISS1-543
A-1155463 Regulator protein BCL2L1 A-1107969
A-1211212 Regulator protein BCL2 A-1210227
IPP/CNRS-A017 Dehydrogenase DHODH IPP/CNRS-A019
MSD-M1PAM GPCR CHRM1 MSD-M1PAM-NC
A-1596586 Ion channel CFTR A-1596584
MSD-CYP11B2 Cytochrome P450 CYP11B2 MSD-CYP11B2 Negative control
THPP-1 Phosphodiesterase PDE10A THPP-1-NC
PPTN GPCR P2RY14 PPTN-NC
BAY-549 Kinase ROCK1, ROCK2 BAY-4900
TP-008 Kinase ACVR1B, TGFBR1 Al11
MLi-2 Kinase LRRK2 MLi-2-NC
UCSF924 GPCR DRD4 UCSF924NC
T3-CLK Kinase CLK1, CLK2, CLK3, CLK4 T3-CLK-N
BAY-293 Nucleotide exchange factor SOS1 BAY-294
A-192621 GPCR EDNRB A-1806262
BI-1230 Protease HCV NS3 BI-1675
TP-024 GPCR GPR52 TP-024n
BI-2540 Reverse transcriptase HIV NNRT BI-2439
BAY-390 Ion channel TRPA1 BAY-9897
BAY-069 Amino acid transaminase BCAT1, BCAT2 BAY-771
TP-030-2 Kinase RIPK1 TP-030n
TP-030-1 Kinase RIPK1 TP-030n
(R)-ZINC-3573 GPCR MRGPRX2 (S)-ZINC-3573
Ogerin GPCR GPR68 ZINC32547799
WM-1119 Transferase KAT6A, KAT6B WM-2474
SR-302 Kinase DDR1, DDR2, MAPK11, MAPK14 SR-301
NVS-MALT1 Protease MALT1 NVS-MALT1-C
BAY-3827 Kinase PRKAA1, RPS6KA1 BAY-974
FS-694 Kinase MAPK14 FM-743
Skepinone-L Kinase MAPK14 FM-743
SR-318 Kinase MAPK14 SR-321
BAY-179 Protease Complex I BAY-070 Yes
BAY-899 GPCR LHCGR BAY-897
BAY-985 Kinase TBK1, IKBKE BAY-440
Borussertib Kinase AKT1, AKT2 RL2578
BAY-091 Kinase PIP4K2A BAY-0361
MSC-4381 Monocarboxylate transporter SLC16A3 MSC-0516
PFI-653 Hydrolase VNN1 PFI-653-N
JNJ-54119936 Nuclear hormone receptor RORC JNJ-53721590
JNJ-42396302 Phosphodiesterase PDE10A JNJ-40573663
TP-040 Hydrolase OGA TP-040n
8RK64 Regulator protein UCHL1 JYQ88
A-446 Hydrolase GLS A-426
BI-1942 Protease CMA1
BI 605906 Kinase IKBKB BI-5026
GSK973 Bromodomains BRD2, BRD3, BRD4, BRDT GSK943
GSK620 Bromodomains BRD2, BRD3, BRD4, BRDT
GSK046 Bromodomains BRD2, BRD3, BRD4, BRDT
GSK789 Bromodomains BRD2, BRD3, BRD4, BRDT GSK791
GSK778 Bromodomains BRD2, BRD3, BRD4, BRDT
BAY-3153 GPCR CCR1 BAY-173
BAY-6672 GPCR PTGFR BAY-403
BI 207127 RNA polymerase HCV NS5B BI-7656
BAY 1816032 Kinase BUB1 BAY-283
JNJ-9350 Oxidase SMOX JNJ-4545
SAFit2 Isomerase FKBP5 ddSAFit2
CCT369260 Transcription factor BCL6 CCT393732
JNJ-39758979 GPCR HRH4 JNJ-39668551
JNJ-6204 Kinase CSNK1D/CSNK1E JNJ-0293
BI-2081 GPCR FFAR1 BI-0340
TP-051 GPCR FFAR1 TP-051n
TP-050 Ion channel GRIN2A TP-050n
GNE-2256 Kinase IRAK4 GNE-6689
BAY1125976 Kinase AKT1/2 BAY-940
JNJ-65355394 Hydrolase OGA JNJ-73924149
TP-061 Helicases Brr2 TP-061N 5 µM
SGC-UBD1031 UBD (ubiquitin binding domain) USP16/HDAC6 SGC-UBD1031N 10 µM
BAY 1816032 2OG BUB1 BAY-283
UNC8732 Methyl Lysine Binder NSD2 UNC8884 3 µM
OICR11029 Transcription factor BCL6 OICR11600 1 µM
PFI-8 YEATS YEATS PFI-8N 1 µM
BI-5524 Chymotrypsin ELANE BI-5525
WEB2086 GPCR PTAFR WEB2387
BIBO3304 GPCR NPY1R BIBO3457
SGK3-PROTAC1 Kinase SGK3 cisSGK3-PROTAC1
VZ185 Bromodomain-containing protein family BRD7, BRD9 cisVZ185
BAY-277 Aminopeptidase METAP2 BAY-8805
BAY-6096 GPCR ADRA2B BAY-726
BAY 1753011 GPCR AVPR1A, AVPR2 BAY-2297
JA310 Kinase MST3, MST4 JA262 < 1 µM
BI-8668 Sodium channels Epithelial sodium channel (ENaC) BI-0337
BI-3812 Transcription factor BCL6 BI-5273
BI-3802 Transcription factor BCL6 BI-5273
JP3000 Nuclear hormone receptor RXRA, RXRB, RXRG JP3001
SGC-GSK3-1 Kinase GSK3 SGC-CDKL5/GSK3-1N 100 nM
SGC-CDKL5/GSK3 Kinase CDKL5, GSK3 SGC-CDKL5/GSK3-1N 100 nM
SGC-CAF382-1 Kinase CDKL5 SGC-CAF268-1N ≤ 100 nM
TP-060 Glucosyltransferase UGCG TP-060n
JNJ-42226314 Serine hydrolase MGLL JNJ-8034
JNJ-4355 BCL2 protein family MCL1 JNJ-78732576
BAY-7081 Phoshodiesterase PDE9A BAY-7424
FHT-2344 SWI/SNF SMARCA2, SMARCA4 FHT-5908
BI-3231 17β-hydroxysteroid dehydrogenases HSD17B13 BI-0955
TH-257 Kinase LIMK1, LIMK2 TH-263 1 µM
JA397 Kinase CDK14-18 JA314 < 1 µM
SGC-PI5P4Kγ/MYLK4-1 Kinase PI5P4K gamma, MYLK4 SGC-PI5P4Kγ/MYLK4-1N 100 nM
SGC-CK2-2 Kinase CK2/CSNK2 SGK-CK2-2N 1 µM
LIJTF500025 Kinase LIMK1, LIMK2 LIJTF500120 < 1 µM
MSC1186 Kinase SRPK MSC5360 < 1 µM
CS640 Kinase CAMK1 CS640s < 1 µM
MU1742 Kinase CK1delta, CK1epsilon MU2027 1 µM
BAY-805 USP (ubiquitin specific protease) USP21 BAY-728 1 µM
MRK-952 Hydrolase NUDT5 MRK-952-NC < 1 µM
MRK-990 Methyltransferase PRMT9, PRMT5 MRK-990-NC < 10 µM
SGC-PIKFYVE-1 Kinase PIKfyve SGC-PIKFYVE-1N 100 nM
MU1700 Kinase ALK1, ALK2 MU1700NC 1 µM
M4K2234 Kinase ALK1, ALK2 M4K2234NC 1 µM
SGC-UBD253 UBD (ubiquitin binding domain) HDAC6 SGC-UBD253N 3 µM
CK156 Kinase STK17A, DRAK1 CKJB71 5 µM
PFI-7 E3 ligase GID4 PFI-7N 1 µM
MRIA9 Kinase SIK1, SIK2, SIK3 MR7 10 µM
Homer WD40 repeat WDR5 nc_WDR5, nc_VHL 1 µM
SGC-SMARCA-BRDVIII Bromodomains PB1(5), SMARCA2/4 SGC-BRDVIII-NC 10 µM
NR162 Kinase CASK NR187 10 µM
PFI-6 YEATS MLLT1, MLLT3 PFI-6N 1 µM
SGC-CK2-1 Kinase CSNK2A1, CSNK2A2 SGC-CK2-1N 100 nM
NVS-MLLT-1 YEATS MLLT1, MLLT3 NVS-MLLT-C 1 µM
SGC-STK17B-1 Kinase STK17B, DRAK2 SGC-STK17B-1N 1 µM
SGC-CLK-1 Kinase CLK1, CLK2, CLK4 SGC-CLK-1N 1 µM
SGC-CAMKK2-1 Kinase CAMKK1, CAMKK2 SGC-CAMKK2-1N 1 µM
PFI-5 Methyltransferase SMYD2 PFI-5N 1 µM
SGC6870 Methyltransferase PRMT6 SGC6870N 1 µM
UNC6934 Methyl Lysine Binder NSD2-PWWP1 UNC7145 1 µM
MU1210 Kinase CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 MU140 1 µM
NVS-BPTF-1 Bromodomains BPTF NVS-BPTF-C < 1 µM
VinSpinIn Spindlin domains Spin1 VinSpinIC 0.5 µM - 3 µM
TP-238 Bromodomains CECR2, BPTF TP-422 < 2 µM
DDR-TRK-1 Kinase DDR, TRK DDR-TRK-1N 5 µM
SKI-73 Methyltransferase CARM1 SKI-73N 1 µM
BI-9321 Methyl Lysine Binder NSD3 BI-9466 0.5 µM - 20 µM
MRK-740 Methyltransferase PRDM9 MRK-740-NC 3 µM
BAY-826 Kinase TIE1, TEK, DDR1, DDR2 BAY-309
BI-665915 Lipoxygenase ALOX5AP BI-0153
SGC3027 Methyltransferase PRMT7 SGC3027N 1 µM
SGC-GAK-1 Kinase GAK SGC-GAK-1N 1 µM
SGC-AAK1-1 Kinase AAK1, BMP2K, BIKE SGC-AAK1-1N 1 µM
BI01383298 Solute carriers SLC13A5 BI01372674 1 µM
L-Moses Bromodomains KAT2A, KAT2B D-Moses 1 µM
BAY-6035 Methyltransferase SMYD3 BAY-444 1 µM
GSK4027 Bromodomains KAT2A, KAT2B GSK4028 1 µM
FM-381 Kinase JAK3 FM-479 100 nM
BAY-850 Bromodomains ATAD2 BAY-460 1 µM
GSK8814 Bromodomains ATAD2, ATAD2B GSK8815 1 µM
GSK6853 Bromodomains BRPF1 GSK9311 < 1 µM
LLY-283 Methyltransferase PRMT5 LLY-284 1 µM
A-395 WD40 repeat EED A-395N 100 nM
NVS-PAK1-1 Kinase PAK1 NVS-PAK1-C 1 µM
TP-472 Bromodomains BRD9, BRD7 TP-472N 1 µM
TP-064 Methyltransferase CARM1 TP-064N 1 µM
BAY-299 Bromodomains TAF1, BRD1 BAY-364 1 µM
GSK864 Dehydrogenase IDH1 GSK990 1 µM
MS023 Methyltransferase PRMT1, PRMT3, CARM1, PRMT6, PRMT8 MS094 1 µM
A-196 Methyltransferase SUV420H1, SUV420H2 SGC2043 1 µM
GSK591 Methyltransferase PRMT5 SGC2096 1 µM
MS049 Methyltransferase CARM1, PRMT6 MS049N 1 µM
NVS-CECR2-1 Bromodomains CECR2 NVS-CECR2-C 1 µM
I-BRD9 Bromodomains BRD9 1 µM
BI-9564 Bromodomains BRD9, BRD7 1 µM
BAY-598 Methyltransferase SMYD2 BAY-369 1 µM
GSK484 Arginine deiminases PAD4 GSK106 1 µM
GSK2801 Bromodomains BAZ2A, BAZ2B GSK8573 1 µM
LP99 Bromodomains BRD9, BRD7 2S,3R-enantiomer 1 µM
NI-57 Bromodomains BRPF1, BRD1, BRPF3 1 µM
PFI-4 Bromodomains BRPF1 1 µM
OF-1 Bromodomains BRPF1, BRD1, BRPF3 <5 µM
SGC707 Methyltransferase PRMT3 XY1 1 µM
BAZ2-ICR Bromodomains BAZ2A, BAZ2B 1 µM
OICR-9429 WD40 repeat WDR5 OICR-0547 1 µM
GSK-LSD1 Lysine Demethylase KDM1A/LSD1 100 nM
LLY-507 (multiple off-targets) Methyltransferase SMYD2 SGC705 1 µM
PFI-3 Bromodomains SMARCA2, PBRM1, SMARCA4 PFI-3oMet 1 µM
A-366 Methyltransferase EHMT1/GLP, EHMT2/G9a 1 µM
UNC1999 Methyltransferase EZH2 UNC2400 1 µM
(R)-PFI-2 Methyltransferase SETD7 (S)-PFI-2 1 µM
SGC-CBP30 Bromodomains CREBBP, EP300 BDOIA513 1 µM
I-CBP112 Bromodomains CREBBP, EP300 1 µM
Bromosporine (BSP) Bromodomains pan-Bromodomain 5 µM
UNC1215 Methyl Lysine Binder L3MBTL3 UNC1079 1 µM
UNC0642 Methyltransferase EHMT2/G9a, EHMT1/GLP 1 µM
GSK343 Methyltransferase EZH2 1 µM
GSK-J1 Lysine Demethylase KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B GSK-J2 (GSK-J5) 100 nM
SGC0946 Methyltransferase DOT1L SGC0649 1 µM
IOX2 2OG PHD2 1 µM
IOX1 2OG Pan-KDM 1 µM - 20 µM
PFI-1 Bromodomains BRD2, BRD3, BRD4, BRDT 1 µM
UNC0638 Methyltransferase EHMT2/G9a, EHMT1/GLP UNC0737 ≤ 1 µM
(+)-JQ1 Bromodomains BRD2, BRD3, BRD4, BRDT (-)-JQ1 1 µM