![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
Please select a protein family
Potent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories.
SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. To acquire a sample, follow the links on the webpage of your desired chemical probe. You can sort the table by clicking the column headers.
The SGC probes set is complemented by the donated probe set
Name | Structures | Protein family | Specific Targets | Control |
In Vivo Activity*![]() |
Added |
---|---|---|---|---|---|---|
GSK4027 |
![]() |
Bromodomains | KAT2A, KAT2B | GSK4028 | 06/17 | |
BI01383298 |
![]() |
Solute carriers | SLC13A5 | BI01372674 | 01/18 | |
T-26c |
![]() |
Protease | MMP13 | T-26f | 06/16 | |
VinSpinIn |
![]() |
Spindlin domains | Spin1 | VinSpinIC | 09/18 | |
BAY-850 |
![]() |
Bromodomains | ATAD2 | BAY-460 | 01/17 | |
SGC6870 |
![]() |
Methyltransferase | PRMT6 | SGC6870N | 06/19 | |
BI-9321 |
![]() |
Methyl Lysine Binder | NSD3 | BI-9466 | 07/18 | |
SKI-73 |
![]() |
Methyltransferase | CARM1 | SKI-73N | 07/17 | |
SGC3027 |
![]() |
Methyltransferase | PRMT7 | SGC3027N | 03/18 | |
A-395 |
![]() |
WD40 repeat | EED | A-395N | 07/16 | |
BAY-6035 |
![]() |
Methyltransferase | SMYD3 | BAY-444 | 06/17 | |
SGC-AAK1-1 |
![]() |
Kinase | AAK1, BMP2K, BIKE | SGC-AAK1-1N | 02/18 | |
SGC-STK17B-1 |
![]() |
Kinase | STK17B, DRAK2 | SGC-STK17B-1N | 02/20 | |
TP-064 |
![]() |
Methyltransferase | CARM1 | TP-064N | 06/16 | |
TP-238 |
![]() |
Bromodomains | CECR2, BPTF | TP-422 | 09/18 | |
FM-381 |
![]() |
Kinase | JAK3 | FM-479 | 02/17 | |
A-485 |
![]() |
Lysine acetyltransferase | CREBBP, EP300 | A-486 | 10/17 | |
SGC-SMARCA-BRDVIII |
![]() |
Bromodomains | PB1(5), SMARCA2/4 | SGC-BRDVIII-NC | 12/20 | |
GSK8814 |
![]() |
Bromodomains | ATAD2, ATAD2B | GSK8815 | 01/17 | |
UNC6934 |
![]() |
Methyl Lysine Binder | NSD2-PWWP1 | UNC7145 | 06/19 | |
TH-257 |
![]() |
Kinase | LIMK1, LIMK2 | TH-263 | 07/17 | |
MRK-740 |
![]() |
Methyltransferase | PRDM9 | MRK-740-NC | 06/18 | |
LLY-283 |
![]() |
Methyltransferase | PRMT5 | LLY-284 | 07/16 | |
PFI-5 |
![]() |
Methyltransferase | SMYD2 | PFI-5N | 07/17 | |
SGC-GAK-1 |
![]() |
Kinase | GAK | SGC-GAK-1N | 02/18 | |
NVS-BPTF-1 |
![]() |
Bromodomains | BPTF | NVS-BPTF-C | No | 02/19 |
PFI-1 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | No | 11/11 | |
PFI-3 |
![]() |
Bromodomains | SMARCA2, PBRM1, SMARCA4 | PFI-3oMet | No | 11/13 |
SGC-CLK-1 |
![]() |
Kinase | CLK1, CLK2, CLK4 | SGC-CLK-1N | No | 02/20 |
OF-1 |
![]() |
Bromodomains | BRPF1, BRD1, BRPF3 | No | 07/14 | |
OICR-9429 |
![]() |
WD40 repeat | WDR5 | OICR-0547 | No | 05/14 |
IOX1 (tool compound) |
![]() |
2OG | Pan-KDM | No | 01/12 | |
UNC1215 |
![]() |
Methyl Lysine Binder | L3MBTL3 | UNC1079 | No | 08/12 |
NVS-PAK1-1 |
![]() |
Kinase | PAK1 | NVS-PAK1-C | No | 06/16 |
FS-694 |
![]() |
Kinase | MAPK14 | FM-743 | No | 01/20 |
NR162 |
![]() |
Kinase | CASK | NR187 | No | 09/20 |
LP99 |
![]() |
Bromodomains | BRD9, BRD7 | 2S,3R-enantiomer | No | 12/14 |
MU1210 |
![]() |
Kinase | CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 | MU140 | No | 05/19 |
I-CBP112 |
![]() |
Bromodomains | CREBBP, EP300 | No | 03/13 | |
SGC707 |
![]() |
Methyltransferase | PRMT3 | XY1 | No | 06/14 |
SR-318 |
![]() |
Kinase | MAPK14 | SR-321 | No | 01/20 |
SGC-CK2-1 |
![]() |
Kinase | CSNK2A1, CSNK2A2 | SGC-CK2-1N | No | 06/20 |
GSK-J1 use pro-drug GSK-J4 for cell assays |
![]() |
Lysine Demethylase | KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B | GSK-J2 (GSK-J5) | No | 07/12 |
I-BRD9 |
![]() |
Bromodomains | BRD9 | No | 05/15 | |
T3-CLK |
![]() |
Kinase | CLK1, CLK2, CLK3, CLK4 | T3-CLK-N | No | 04/19 |
TP-008 |
![]() |
Kinase | ALK4, ALK5 | AI11 | No | 05/19 |
Bromosporine (BSP) (tool compound) |
![]() |
Bromodomains | pan-Bromodomain | No | 01/13 | |
SGC-CBP30 |
![]() |
Bromodomains | CREBBP, EP300 | BDOIA513 | No | 03/13 |
MS023 |
![]() |
Methyltransferase | PRMT1, PRMT3, CARM1, PRMT6, PRMT8 | MS094 | No | 07/15 |
PFI-4 |
![]() |
Bromodomains | BRPF1 | No | 12/14 | |
NVS-CECR2-1 |
![]() |
Bromodomains | CECR2 | NVS-CECR2-C | No | 06/15 |
SR-302 |
![]() |
Kinase | DDR1, DDR2, MAPK11, MAPK14 | SR-301 | No | 06/20 |
GSK-LSD1 |
![]() |
Lysine Demethylase | KDM1A/LSD1 | No | 03/14 | |
BI 99179 |
![]() |
Synthase | FASN | BI 99990 | No | 05/18 |
PFI-2 |
![]() |
Methyltransferase | SETD7 | (S)-PFI-2 | No | 05/13 |
MS049 |
![]() |
Methyltransferase | CARM1, PRMT6 | MS049N | No | 06/15 |
SGC-CAMKK2-1 |
![]() |
Kinase | CAMKK1, CAMKK2 | SGC-CAMKK2-1N | No | 01/20 |
A-366 |
![]() |
Methyltransferase | EHMT1/GLP, EHMT2/G9a | No | 06/13 | |
BAY-299 |
![]() |
Bromodomains | TAF1, BRD1 | BAY-364 | No | 06/16 |
BAY-3827 |
![]() |
Kinase | PRKAA1, RPS6KA1 | BAY-974 | No | 01/20 |
LLY-507 (Multiple Off-target Effects) |
![]() |
Methyltransferase | SMYD2 | SGC705 | No | 11/13 |
A-196 |
![]() |
Methyltransferase | SUV420H1, SUV420H2 | A-197, SGC2043 | No | 07/15 |
BAY-885 |
![]() |
Kinase | MAPK7 | BAY-693 | No | 11/18 |
TP-008 |
![]() |
Kinase | ACVR1B, TGFBR1 | Al11 | No | 06/19 |
IPP/CNRS-A017 |
![]() |
Dehydrogenase | DHODH | IPP/CNRS-A019 | No | 10/19 |
UNC0638 |
![]() |
Methyltransferase | EHMT2/G9a, EHMT1/GLP | UNC0737 | No | 06/10 |
(R)-ZINC-3573 |
![]() |
GPCR | MRGPRX2 | (S)-ZINC-3573 | No | 06/20 |
PFI-6 |
![]() |
YEATS | MLLT1, MLLT3 | PFI-6N | No | 06/20 |
NI-57 |
![]() |
Bromodomains | BRPF1, BRD1, BRPF3 | No | 12/14 | |
A-1596586 |
![]() |
Ion channel | CFTR | A-1596584 | No | 06/19 |
T3-CLK |
![]() |
Kinase | CLK1, CLK2, CLK3, CLK4 | T3-CLK-N | No | 05/19 |
GSK343 |
![]() |
Methyltransferase | EZH2 | No | 08/12 | |
SGC0946 |
![]() |
Methyltransferase | DOT1L | SGC0649 | No | 08/12 |
BTZO-1 |
![]() |
Cytokine | MIF | BTZO-4 | No | 05/18 |
GSK591 |
![]() |
Methyltransferase | PRMT5 | SGC2096 | No | 07/15 |
NVS-MLLT-1 |
![]() |
YEATS | MLLT1, MLLT3 | NVS-iMLLT-C | No | 03/20 |
IOX2 (requires >>> 1 microM for cell assays) |
![]() |
2OG | PHD2 | No | 02/12 | |
BAY-293 |
![]() |
Nucleotide exchange factor | SOS1 | BAY-294 | No | 04/19 |
THPP-1 |
![]() |
Phosphodiesterase | PDE10A | THPP-1-NC | Yes | 06/19 |
BAY-7598 |
![]() |
Protease | MMP12 | BAY-694 | Yes | 05/18 |
BAY-707 |
![]() |
Hydrolase | NUDT1 | BAY-604 | Yes | 05/18 |
GSK484 |
![]() |
Arginine deiminases | PAD4 | GSK106 | Yes | 03/15 |
BI 653048 |
![]() |
Nuclear hormone receptor | NR3C1 | BI-3047 | Yes | 11/18 |
BAY-985 |
![]() |
Kinase | TBK1, IKBKE | BAY-440 | Yes | 01/20 |
BAZ2-ICR |
![]() |
Bromodomains | BAZ2A, BAZ2B | Yes | 05/14 | |
MRL-SYKi |
![]() |
Kinase | SYK | MRL-SYKi-NC | Yes | 05/18 |
ABT-546 |
![]() |
GPCR | EDNRA | A-545 | Yes | 05/18 |
BI-1230 |
![]() |
Protease | HCV NS3 | BI-1675 | Yes | 03/19 |
BAY-069 |
![]() |
Amino acid transaminase | BCAT1, BCAT2 | BAY-771 | Yes | 09/20 |
NVS-MALT1 |
![]() |
Protease | MALT1 | NVS-MALT1-C | Yes | 02/20 |
BAY-474 |
![]() |
Kinase | MET | BAY-827 | Yes | 05/18 |
BI-9627 |
![]() |
Solute carriers | SLC9A1 | BI-0054 | Yes | 05/18 |
BAY-598 |
![]() |
Methyltransferase | SMYD2 | BAY-369 | Yes | 04/15 |
BI-2545 |
![]() |
Phosphodiesterase | ENPP2 | BI-3017 | Yes | 11/18 |
BAY-549 |
![]() |
Kinase | ROCK1, ROCK2 | BAY-4900 | Yes | 06/19 |
A-1211212 |
![]() |
Regulator protein | BCL2 | A-1210227 | Yes | 11/19 |
CRTH2 antagonist |
![]() |
GPCR | PTGDR2 | CRTH2 negative control | Yes | 05/18 |
KISS1-305 |
![]() |
GPCR | KISS1R | KISS1-543 | Yes | 05/18 |
TP-021 |
![]() |
Transcription factor | BCL6 | TP-021n | Yes | 11/18 |
TP-030-1 |
![]() |
Kinase | RIPK1 | TP-030n | Yes | 09/20 |
L-Moses |
![]() |
Bromodomains | KAT2A, KAT2B | D-Moses | Yes | 10/17 |
JQ1 |
![]() |
Bromodomains | BRD2, BRD3, BRD4, BRDT | (-)-JQ1 | Yes | 06/10 |
PF-05105679 |
![]() |
Ion channel | TRPM8 | PF-05257137 | Yes | 05/18 |
BI-4394 |
![]() |
Protease | MMP13 | BI-4395 | Yes | 11/18 |
GSK6853 |
![]() |
Bromodomains | BRPF1 | GSK9311 | Yes | 01/17 |
MLi-2 |
![]() |
Kinase | LRRK2 | MLi-2-NC | Yes | 05/19 |
MSD-M1PAM |
![]() |
GPCR | CHRM1 | MSD-M1PAM-NC | Yes | 08/19 |
BI 665915 |
![]() |
Lipoxygenase | ALOX5AP | BI-0153 | Yes | 05/18 |
ABT-100 |
![]() |
Transferase | FNTB | A-108 | Yes | 05/18 |
BAY-678 |
![]() |
Protease | ELANE | BAY-677 | Yes | 10/15 |
BAY-784 |
![]() |
GPCR | GNRHR | BAY-786 | Yes | 11/18 |
Ogerin |
![]() |
GPCR | GPR68 | ZINC32547799 | Yes | 06/20 |
BI-1935 |
![]() |
Hydrolase | EPHX2 | BI-2049 | Yes | 05/18 |
BAY-678 |
![]() |
Protease | ELANE | BAY-677 | Yes | 05/18 |
BI 207127 |
![]() |
RNA polymerase | HCV NS5B | BI-7656 | Yes | 11/20 |
MSD-CYP11B2 |
![]() |
Cytochrome P450 | CYP11B2 | MSD-CYP11B2 Negative control | Yes | 06/19 |
ERKi |
![]() |
Kinase | MAPK3, MAPK1 | ERKi-NC | Yes | 05/18 |
BAY-386 |
![]() |
GPCR | F2R | BAY-448 | Yes | 05/18 |
BI-1950 |
![]() |
Integrin | ITGAL | BI-9446 | Yes | 11/18 |
BAY-899 |
![]() |
GPCR | LHCGR | BAY-897 | Yes | 01/20 |
MRK-560 |
![]() |
Protease | Gamma secretase complex | GSI-NC | Yes | 05/18 |
T-26c |
![]() |
Protease | MMP13 | T-26f | Yes | 05/18 |
A-192621 |
![]() |
GPCR | EDNRB | A-1806262 | Yes | 03/19 |
BAY-390 |
![]() |
Ion channel | TRAP1 | BAY-9897 | Yes | 09/20 |
A-485 |
![]() |
Transferase | EP300, CREBBP | A-486 | Yes | 05/18 |
BI 639667 |
![]() |
GPCR | CCR1 | BI-9307 | Yes | 11/18 |
PPTN |
![]() |
GPCR | P2RY14 | PPTN-NC | Yes | 06/19 |
A-1155463 |
![]() |
Regulator protein | BCL2L1 | A-1107969 | Yes | 11/19 |
MRL-650 |
![]() |
GPCR | CNR1 | MRL-CB1-NC | Yes | 05/18 |
UNC1999 |
![]() |
Methyltransferase | EZH2 | UNC2400 | Yes | 05/13 |
PF-04457845 |
![]() |
Hydrolase | FAAH | PF-04875474 | Yes | 05/18 |
TP-024 |
![]() |
GPCR | GPR52 | TP-024n | Yes | 11/18 |
TP-030-2 |
![]() |
Kinase | RIPK1 | TP-030n | Yes | 09/20 |
DDR-TRK-1 |
![]() |
Kinase | DDR, TRK | DDR-TRK-1N | Yes | 08/18 |
TP-004 |
![]() |
Protease | METAP2 | TPn-004 | Yes | 05/18 |
UNC0642 |
![]() |
Methyltransferase | EHMT2/G9a, EHMT1/GLP | Yes | 08/12 | |
BAY-826 |
![]() |
Kinase | TIE1, TEK, DDR1, DDR2 | BAY-309 | Yes | 05/18 |
(R)-9s |
![]() |
GPCR | ADRA1D | (S)-9s | Yes | 05/18 |
GSK864 |
![]() |
Dehydrogenase | IDH1 | GSK990 | Yes | 11/15 |
TP-020 |
![]() |
Transferase | MGAT2 | TP-020n | Yes | 11/18 |
Skepinone-L |
![]() |
Kinase | MAPK14 | FM-743 | Yes | 01/20 |
GSK2801 |
![]() |
Bromodomains | BAZ2A, BAZ2B | GSK8573 | Yes | 12/14 |
PF-04418948 |
![]() |
GPCR | PTGER2 | PF-04475866 | Yes | 05/18 |
A-079 |
![]() |
Ion channel | TRPA1 | A-226 | Yes | 11/18 |
UCSF924 |
![]() |
GPCR | DRD4 | UCSF924NC | Yes | 04/19 |
BAY-6672 |
![]() |
GPCR | PTGFR | BAY-403 | Yes | 11/20 |
ABT-724 |
![]() |
GPCR | DRD4 | A-769 | Yes | 05/18 |
BAY-1797 |
![]() |
Ion channel | P2X4 | BAY-207 | Yes | 11/18 |
WM-1119 |
![]() |
Transferase | KAT6A, KAT6B | WM-2474 | Yes | 06/20 |
BAY-179 |
![]() |
Complex I | BAY-070 | Yes | 01/20 | |
GSM1 |
![]() |
Protease | Gamma secretase complex | GSM-NC | Yes | 05/18 |
BI-9564 |
![]() |
Bromodomains | BRD9, BRD7 | Yes | 04/15 | |
BAY-876 |
![]() |
Solute carriers | SLC2A1 | BAY-588 | Yes | 05/18 |
TP-472 |
![]() |
Bromodomains | BRD9, BRD7 | TP-472N | Yes | 06/16 |
BI-2540 |
![]() |
Reverse transcriptase | HIV NNRT | BI-2439 | Yes | 11/20 |