Chemical Probes

Chemical Probes
Chemical Handles
Phylogenetic tree view

Chemical Probes

Potent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories.

Donated probe website KCGS website

SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. To acquire a sample, follow the links on the webpage of your desired chemical probe. You can sort the table by clicking the column headers.

Brochure - SGC Chemical Probes ( May 2023 )

The SGC probes set is complemented by the donated probe set

Brochure - Donated Chemical Probes ( July 2021 )

Name	Protein family	Specific Targets	Control	In Vivo Activity*	Added
BAY-6035	Methyltransferase	SMYD3	BAY-444		06/17
UNC6934	Methyl Lysine Binder	NSD2-PWWP1	UNC7145		06/19
TP-064	Methyltransferase	CARM1	TP-064N		06/16
SGC-GAK-1	Kinase	GAK	SGC-GAK-1N		02/18
MSC1186	Kinase	SRPK	MSC5360		01/23
FM-381	Kinase	JAK3	FM-479		02/17
BI01383298	Solute carriers	SLC13A5	BI01372674		01/18
GSK8814	Bromodomains	ATAD2, ATAD2B	GSK8815		01/17
VinSpinIn	Spindlin domains	Spin1	VinSpinIC		09/18
SGC-CAF382-1	Kinase	CDKL5	SGC-CAF268-1N		09/23
TH-257	Kinase	LIMK1, LIMK2	TH-263		07/17
LLY-283	Methyltransferase	PRMT5	LLY-284		07/16
BI-9321	Methyl Lysine Binder	NSD3	BI-9466		07/18
JA397	Kinase	CDK14-18	JA314		07/23
PFI-5	Methyltransferase	SMYD2	PFI-5N		07/17
SGC6870	Methyltransferase	PRMT6	SGC6870N		06/19
SGC3027	Methyltransferase	PRMT7	SGC3027N		03/18
SGC-CK2-2	Kinase	CK2/CSNK2	SGK-CK2-2N		05/23
GSK4027	Bromodomains	KAT2A, KAT2B	GSK4028		06/17
SGC-AAK1-1	Kinase	AAK1, BMP2K, BIKE	SGC-AAK1-1N		02/18
BAY-850	Bromodomains	ATAD2	BAY-460		01/17
TP-238	Bromodomains	CECR2, BPTF	TP-422		09/18
SGC-STK17B-1	Kinase	STK17B, DRAK2	SGC-STK17B-1N		02/20
TH-257	Kinase	LIMK1, LIMK2	TH-263		07/23
SKI-73	Methyltransferase	CARM1	SKI-73N		07/17
A-395	WD40 repeat	EED	A-395N		07/16
MRK-740	Methyltransferase	PRDM9	MRK-740-NC		06/18
SGC-SMARCA-BRDVIII	Bromodomains	PB1(5), SMARCA2/4	SGC-BRDVIII-NC		12/20
MS049	Methyltransferase	CARM1, PRMT6	MS049N	No	06/15
GSK-LSD1	Lysine Demethylase	KDM1A/LSD1		No	03/14
SR-318	Kinase	MAPK14	SR-321	No	01/20
PFI-2	Methyltransferase	SETD7	(S)-PFI-2	No	05/13
BI 99179	Synthase	FASN	BI 99990	No	05/18
BI-1942	Protease	CMA1		No	06/21
PFI-6	YEATS	MLLT1, MLLT3	PFI-6N	No	06/20
A-366	Methyltransferase	EHMT1/GLP, EHMT2/G9a		No	06/13
A-196	Methyltransferase	SUV420H1, SUV420H2	A-197, SGC2043	No	07/15
BAY-885	Kinase	MAPK7	BAY-693	No	11/18
NVS-BPTF-1	Bromodomains	BPTF	NVS-BPTF-C	No	02/19
TP-008	Kinase	ACVR1B, TGFBR1	Al11	No	06/19
SGC-UBD253	UBD (ubiquitin binding domain)	HDAC6	SGC-UBD253N	No	01/22
LLY-507 (Multiple Off-target Effects)	Methyltransferase	SMYD2	SGC705	No	11/13
SGC-GSK3-1	Kinase	GSK3	SGC-CDKL5/GSK3-1N	No	09/23
NVS-PAK1-1	Kinase	PAK1	NVS-PAK1-C	No	06/16
NVS-MLLT-1	YEATS	MLLT1, MLLT3	NVS-iMLLT-C	No	03/20
SR-302	Kinase	DDR1, DDR2, MAPK11, MAPK14	SR-301	No	06/20
UNC0638	Methyltransferase	EHMT2/G9a, EHMT1/GLP	UNC0737	No	06/10
PFI-7	E3 ligase	GID4	PFI-7N	No	09/21
NI-57	Bromodomains	BRPF1, BRD1, BRPF3		No	12/14
GSK591	Methyltransferase	PRMT5	SGC2096	No	07/15
BTZO-1	Cytokine	MIF	BTZO-4	No	05/18
SGC-CLK-1	Kinase	CLK1, CLK2, CLK4	SGC-CLK-1N	No	02/20
GSK343	Methyltransferase	EZH2		No	08/12
MRK-952	Hydrolase	NUDT5	MRK-952-NC	No	10/22
BAY-3827	Kinase	PRKAA1, RPS6KA1	BAY-974	No	01/20
SGC0946	Methyltransferase	DOT1L	SGC0649	No	08/12
BAY-293	Nucleotide exchange factor	SOS1	BAY-294	No	04/19
Homer	WD40 repeat	WDR5	nc_WDR5 and nc_VHL	No	07/21
IPP/CNRS-A017	Dehydrogenase	DHODH	IPP/CNRS-A019	No	10/19
IOX2 (requires >>> 1 microM for cell assays)	2OG	PHD2		No	02/12
PFI-1	Bromodomains	BRD2, BRD3, BRD4, BRDT		No	11/11
SGC-PIKFYVE-1	Kinase	PIKfyve	SGC-PIKFYVE-1N	No	10/22
PFI-3	Bromodomains	SMARCA2, PBRM1, SMARCA4	PFI-3oMet	No	11/13
NR162	Kinase	CASK	NR187	No	09/20
A-1596586	Ion channel	CFTR	A-1596584	No	06/19
(R)-ZINC-3573	GPCR	MRGPRX2	(S)-ZINC-3573	No	06/20
OF-1	Bromodomains	BRPF1, BRD1, BRPF3		No	07/14
BAY-091	Kinase	PIP4K2A	BAY-0361	No	10/21
MU1210	Kinase	CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2	MU140	No	05/19
OICR-9429	WD40 repeat	WDR5	OICR-0547	No	05/14
BAY-299	Bromodomains	TAF1, BRD1	BAY-364	No	06/16
SGC-CK2-1	Kinase	CSNK2A1, CSNK2A2	SGC-CK2-1N	No	06/20
IOX1 (tool compound)	2OG	Pan-KDM		No	01/12
UNC1215	Methyl Lysine Binder	L3MBTL3	UNC1079	No	08/12
LP99	Bromodomains	BRD9, BRD7	2S,3R-enantiomer	No	12/14
CK156	Kinase	STK17A, DRAK1	CKJB71	No	10/21
SGC-CDKL5_GSK3	Kinase	CDKL5, GSK3	SGC-CDKL5/GSK3-1N	No	09/23
I-CBP112	Bromodomains	CREBBP, EP300		No	03/13
BAY-805	USP (ubiquitin specific protease)	USP21	BAY-728	No	10/22
SGC707	Methyltransferase	PRMT3	XY1	No	06/14
T3-CLK	Kinase	CLK1, CLK2, CLK3, CLK4	T3-CLK-N	No	04/19
GSK-J1 use pro-drug GSK-J4 for cell assays	Lysine Demethylase	KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B	GSK-J2 (GSK-J5)	No	07/12
I-BRD9	Bromodomains	BRD9		No	05/15
MS023	Methyltransferase	PRMT1, PRMT3, CARM1, PRMT6, PRMT8	MS094	No	07/15
SGC-CAMKK2-1	Kinase	CAMKK1, CAMKK2	SGC-CAMKK2-1N	No	01/20
Bromosporine (BSP) (tool compound)	Bromodomains	pan-Bromodomain		No	01/13
MRK-990	Methyltransferase	PRMT9, PRMT5	MRK-990-NC	No	10/22
FS-694	Kinase	MAPK14	FM-743	No	01/20
SGC-CBP30	Bromodomains	CREBBP, EP300	BDOIA513	No	03/13
GSK789	Bromodomains	BRD2, BRD3, BRD4, BRDT	GSK791	No	02/21
PFI-4	Bromodomains	BRPF1		No	12/14
SGC-PI5P4Kγ/MYLK4-1	Kinase	PI5P4K gamma, MYLK4	SGC-PI5P4Kγ/MYLK4-1N	No	05/23
NVS-CECR2-1	Bromodomains	CECR2	NVS-CECR2-C	No	06/15
A-485	Transferase	EP300, CREBBP	A-486	Yes	05/18
Borussertib	Kinase	AKT1, AKT2	RL2578	Yes	10/21
BI 639667	GPCR	CCR1	BI-9307	Yes	11/18
TP-060	Glucosyltransferase	GCLC	TP-060n	Yes	09/23
PPTN	GPCR	P2RY14	PPTN-NC	Yes	06/19
MU1700	Kinase	ALK1, ALK2	MU1700NC	Yes	02/22
BAY-3153	GPCR	CCR1	BAY-173	Yes	02/21
MRL-650	GPCR	CNR1	MRL-CB1-NC	Yes	05/18
PF-04457845	Hydrolase	FAAH	PF-04875474	Yes	05/18
JNJ-6204	Kinase	CSNK1D/CSNK1E	JNJ-0293	Yes	09/22
TP-024	GPCR	GPR52	TP-024n	Yes	11/18
MSD-CYP11B2	Cytochrome P450	CYP11B2	MSD-CYP11B2 Negative control	Yes	06/19
Ogerin	GPCR	GPR68	ZINC32547799	Yes	06/20
UNC1999	Methyltransferase	EZH2	UNC2400	Yes	05/13
TP-004	Protease	METAP2	TPn-004	Yes	05/18
MSC-4381	Monocarboxylate transporter	SLC16A3	MSC-0516	Yes	09/21
JNJ-4355	BCL2 protein family	MCL1	JNJ-78732576	Yes	09/23
BAY-899	GPCR	LHCGR	BAY-897	Yes	01/20
BI 207127	RNA polymerase	HCV NS5B	BI-7656	Yes	11/20
(R)-9s	GPCR	ADRA1D	(S)-9s	Yes	05/18
TP-051	GPCR	FFAR1	TP-051n	Yes	09/22
TP-020	Transferase	MGAT2	TP-020n	Yes	11/18
UNC0642	Methyltransferase	EHMT2/G9a, EHMT1/GLP		Yes	08/12
MU1742	Kinase	CK1δ, CK1ε	MU2027	Yes	10/22
BAY-826	Kinase	TIE1, TEK, DDR1, DDR2	BAY-309	Yes	05/18
GSK973	Bromodomains	BRD2, BRD3, BRD4, BRDT	GSK943	Yes	02/21
PF-04418948	GPCR	PTGER2	PF-04475866	Yes	05/18
JNJ-54119936	Nuclear hormone receptor	RORC	JNJ-53721590	Yes	09/21
A-079	Ion channel	TRPA1	A-226	Yes	11/18
BAY 1816032	Kinase	BUB1	BAY-283	Yes	10/22
UCSF924	GPCR	DRD4	UCSF924NC	Yes	04/19
A-1155463	Regulator protein	BCL2L1	A-1107969	Yes	11/19
GSK2801	Bromodomains	BAZ2A, BAZ2B	GSK8573	Yes	12/14
BAY-390	Ion channel	TRPA1	BAY-9897	Yes	09/20
GNE-2256	Kinase	IRAK4	GNE-6689	Yes	11/21
BAY-1797	Ion channel	P2X4	BAY-207	Yes	11/18
ABT-724	GPCR	DRD4	A-769	Yes	05/18
GSK046	Bromodomains	BRD2, BRD3, BRD4, BRDT		Yes	02/21
GSM1	Protease	Gamma secretase complex	GSM-NC	Yes	05/18
TP-040	Hydrolase	OGA	TP-040n	Yes	09/21
BAY-876	Solute carriers	SLC2A1	BAY-588	Yes	05/18
SAFit2	Isomerase	FKBP5	ddSAFit2	Yes	09/22
TP-030-2	Kinase	RIPK1	TP-030n	Yes	09/20
BI-9564	Bromodomains	BRD9, BRD7		Yes	04/15
GSK484	Arginine deiminases	PAD4	GSK106	Yes	03/15
BAY-707	Hydrolase	NUDT1	BAY-604	Yes	05/18
JNJ-65355394	Hydrolase	OGA	JNJ-73924149	Yes	11/21
BI 653048	Nuclear hormone receptor	NR3C1	BI-3047	Yes	11/18
BI-3231	17β-hydroxysteroid dehydrogenases	HSD17B13	BI-0955	Yes	09/23
Skepinone-L	Kinase	MAPK14	FM-743	Yes	01/20
BAY-7598	Protease	MMP12	BAY-694	Yes	05/18
GSK778	Bromodomains	BRD2, BRD3, BRD4, BRDT		Yes	02/21
MRL-SYKi	Kinase	SYK	MRL-SYKi-NC	Yes	05/18
A-446	Hydrolase	GLS	A-426	Yes	07/21
TP-472	Bromodomains	BRD9, BRD7	TP-472N	Yes	06/16
ABT-546	GPCR	EDNRA	A-545	Yes	05/18
JNJ-39758979	GPCR	HRH4	JNJ-39668551	Yes	09/22
BI-1230	Protease	HCV NS3	BI-1675	Yes	03/19
BAZ2-ICR	Bromodomains	BAZ2A, BAZ2B		Yes	05/14
BAY-598	Methyltransferase	SMYD2	BAY-369	Yes	04/15
BI-9627	Solute carriers	SLC9A1	BI-0054	Yes	05/18
BI-2545	Phosphodiesterase	ENPP2	BI-3017	Yes	11/18
JNJ-42226314	Serine hydrolase	MGLL	JNJ-8034	Yes	09/23
BAY-549	Kinase	ROCK1, ROCK2	BAY-4900	Yes	06/19
M4K2234	Kinase	ALK1, ALK2	M4K2234NC	Yes	02/22
BAY-179		Complex I	BAY-070	Yes	01/20
BAY-474	Kinase	MET	BAY-827	Yes	05/18
BAY-6672	GPCR	PTGFR	BAY-403	Yes	11/20
BI 605906	Kinase	IKBKB	BI-5026	Yes	06/21
KISS1-305	GPCR	KISS1R	KISS1-543	Yes	05/18
BI-2081	GPCR	FFAR1	BI-0340	Yes	09/22
TP-021	Transcription factor	BCL6	TP-021n	Yes	11/18
THPP-1	Phosphodiesterase	PDE10A	THPP-1-NC	Yes	06/19
CS640	Kinase	CAMK1	CS640s	Yes	01/23
WM-1119	Transferase	KAT6A, KAT6B	WM-2474	Yes	06/20
CRTH2 antagonist	GPCR	PTGDR2	CRTH2 negative control	Yes	05/18
PF-05105679	Ion channel	TRPM8	PF-05257137	Yes	05/18
PFI-653	Hydrolase	VNN1	PFI-653-N	Yes	09/21
BI-4394	Protease	MMP13	BI-4395	Yes	11/18
BAY-7081	Phoshodiesterase	PDE9A	BAY-7424	Yes	09/23
MLi-2	Kinase	LRRK2	MLi-2-NC	Yes	05/19
BAY-985	Kinase	TBK1, IKBKE	BAY-440	Yes	01/20
JQ1	Bromodomains	BRD2, BRD3, BRD4, BRDT	(-)-JQ1	Yes	06/10
BI-2540	Reverse transcriptase	HIV NNRT	BI-2439	Yes	11/20
GSK864	Dehydrogenase	IDH1	GSK990	Yes	11/15
ABT-100	Transferase	FNTB	A-108	Yes	05/18
TP-050	Ion channel	GRIN2A	TP-050n	Yes	09/22
L-Moses	Bromodomains	KAT2A, KAT2B	D-Moses	Yes	10/17
BAY-784	GPCR	GNRHR	BAY-786	Yes	11/18
NVS-MALT1	Protease	MALT1	NVS-MALT1-C	Yes	02/20
BI 665915	Lipoxygenase	ALOX5AP	BI-0153	Yes	05/18
GSK620	Bromodomains	BRD2, BRD3, BRD4, BRDT		Yes	02/21
BI-1935	Hydrolase	EPHX2	BI-2049	Yes	05/18
JNJ-42396302	Phosphodiesterase	PDE10A	JNJ-40573663	Yes	09/21
GSK6853	Bromodomains	BRPF1	GSK9311	Yes	01/17
BAY-678	Protease	ELANE	BAY-677	Yes	05/18
JNJ-9350	Oxidase	SMOX	JNJ-4545	Yes	09/22
DDR-TRK-1	Kinase	DDR, TRK	DDR-TRK-1N	Yes	08/18
MRIA9	Kinase	SIK1, SIK2, SIK3	MR7	Yes	08/21
A-1211212	Regulator protein	BCL2	A-1210227	Yes	11/19
BAY-069	Amino acid transaminase	BCAT1, BCAT2	BAY-771	Yes	09/20
BAY-386	GPCR	F2R	BAY-448	Yes	05/18
BAY1125976	Kinase	AKT1/2	BAY-940	Yes	11/21
BI-1950	Integrin	ITGAL	BI-9446	Yes	11/18
FHT-2344	SWI/SNF	SMARCA2, SMARCA4	FHT-5908	Yes	09/23
ERKi	Kinase	MAPK3, MAPK1	ERKi-NC	Yes	05/18
MRK-560	Protease	Gamma secretase complex	GSI-NC	Yes	05/18
8RK64	Regulator protein	UCHL1	JYQ88	Yes	09/21
T-26c	Protease	MMP13	T-26f	Yes	05/18
CCT369260	Transcription factor	BCL6	CCT393732	Yes	09/22
A-192621	GPCR	EDNRB	A-1806262	Yes	03/19
MSD-M1PAM	GPCR	CHRM1	MSD-M1PAM-NC	Yes	08/19
TP-030-1	Kinase	RIPK1	TP-030n	Yes	09/20

Chemical Handles

This versatile modality can be used to develop tools for proximity-inducing chemistry, tracers for target engagement assays, PROTACs, chemical inducers of degradation, and pull-down reagents. Handles bind their target with Kd < 1 micromolar. Their selectivity and cell activity has not been determined.

Chemical Handle	Chemical Probe	Structures	Protein family	Specific Targets	Control	In Vivo Activity*	Added
PFI-E3H1	PFI-7		E3 ligase	GID4	PFI-7N	No	09/21

Please select a protein family

Bromodomains

( ( ( ASH1L:0.42656, ( SP100:0.36789, ( SP110:0.33224, ( SP140:0.13671, SP140L:0.10984) :0.20058) :0.03793) :0.06052) :0.01373, ( ( ( ATAD2:0.26940, ATAD2B:0.26369) :0.19033, ( ( ( ( ( BRD1:0.22380, BRPF3:0.22705) :0.01451, BRPF1:0.23801) :0.20719, ( ( ( ( ( ( BRD2:0.19557, BRD3:0.19148) :0.04050, BRD4:0.25182) :0.02415, BRDT:0.28925) :0.14057, PBRM1:0.44189) :0.00803, ( CREBBP:0.20246, EP300:0.20268) :0.23148) :0.00872, ( ( BRD7:0.33523, BRD9:0.32809) :0.08483, ( CECR2:0.43144, KIAA2026:0.43985) :0.00515) :0.00941) :0.00414) :0.00503, ( ( BRWD1:0.23336, ( BRWD3:0.23371, PHIP:0.22856) :0.00717) :0.20977, ( ZMYND11:0.36547, ZMYND8:0.37118) :0.07274) :0.01167) :0.00465, ( TAF1:0.04053, TAF1L:0.04161) :0.41155) :0.00158) :0.00393, BRD8:0.44351) :0.00285) :0.00187, ( ( ( BAZ1A:0.40491, BAZ1B:0.40021) :0.02117, ( BAZ2A:0.35523, BAZ2B:0.35501) :0.06222) :0.02521, ( MLL:0.41568, ( ( ( TRIM24:0.25638, TRIM33:0.25600) :0.09230, TRIM28:0.34971) :0.03714, TRIM66:0.38654) :0.04652) :0.01663) :0.00258, ( ( BPTF:0.42133, ( KAT2A:0.15500, KAT2B:0.14788) :0.26722) :0.02034, ( SMARCA2:0.11640, SMARCA4:0.11442) :0.33318) :0.00435);

Lysine Demethylase

( ( ( ( JARID2:0.43039, ( ( ( ( KDM4A/JMJD2A:0.23155, KDM4C/JMJD2C:0.23341) :0.01707, KDM4B/JMJD2B:0.24566) :0.01607, ( KDM4D/JMJD2D:0.16619, KDM4DL/JMJD2E:0.17175) :0.06332) :0.15741, ( ( KDM5A/JARID1A:0.23147, KDM5B/JARID1B:0.24003) :0.02678, ( KDM5C/JARID1C:0.06805, KDM5D/JARID1D:0.07750) :0.18760) :0.14048) :0.03729) :0.01341, ( MINA:0.35985, NO66/FLJ21802:0.34553) :0.09246) :0.00726, ( ( ( JHDM1D/KIAA1718:0.30283, ( PHF2:0.26273, PHF8:0.26463) :0.04507) :0.10219, ( KDM2A/FBXL11:0.24364, KDM2B/FBXL10:0.23571) :0.16985) :0.01908, JMJD6:0.41429) :0.03462) :0.00458, ( ( JMJD1C:0.30946, ( KDM3A/JMJD1A:0.26975, KDM3B/JMJD1B:0.25258) :0.06381) :0.12378, ( JMJD5:0.43831, ( ( KDM6A/UTX:0.06705, UTY:0.06732) :0.27041, KDM6B/JMJD3:0.33895) :0.11043) :0.01232) :0.00148, ( KDM1A/LSD1:0.38589, KDM1B/LSD2:0.38297) :0.08988);

Methyl Lysine Binder

( ( L3MBTL:0.26880, ( ( L3MBTL2:0.22568, MBTD1:0.22655) :0.17920, ( ( SCMH1:0.26354, SCML2:0.26828) :0.12779, ( SFMBT1:0.22793, SFMBT2:0.23512) :0.13803) :0.02634) :0.10947) :0.01818, L3MBTL3:0.27089, L3MBTL4:0.23794);

Methyltransferase

( ( ( ( ( ( ( ASH1L:0.41664, ( ( SETD3:0.41040, SETD4:0.41233) :0.00239, SETD6:0.41336) :0.04317) :0.00783, ( ( ( ( SMYD1:0.34933, SMYD3:0.34226) :0.00652, SMYD2:0.34805) :0.05781, SMYD4:0.40382) :0.01255, SMYD5:0.42036) :0.03407) :0.00364, ( ( ( ( CARM1:0.35324, ( PRMT2:0.33715, PRMT6:0.32951) :0.01450) :0.01142, ( ( PRMT1:0.11741, PRMT8:0.11805) :0.16780, PRMT3:0.29132) :0.07270) :0.06188, ( PRMT7:0.41262, PRMT9:0.40675) :0.01709) :0.03029, PRMT5:0.44807) :0.01398) :0.00463, ( ( ( ( CAMKMT:0.42587, EEF2KMT:0.42552) :0.00950, ( ( METTL21A:0.35150, METTL21D:0.34116) :0.03059, METTL21C:0.37356) :0.05156) :0.00986, SETD2:0.41629) :0.01686, ( ( ( ( ( ( EHMT1/GLP:0.26312, EHMT2/G9A:0.26663) :0.10422, ( SUV39H1:0.20671, SUV39H2:0.20548) :0.16629) :0.02669, ( SETDB1:0.34392, SETDB2:0.35705) :0.06209) :0.01897, SETMAR:0.43380) :0.00575, ( NSD1:0.28947, ( WHSC1:0.28335, WHSC1L1:0.28588) :0.02046) :0.12647) :0.01053, ( ( ( EZH1:0.17720, EZH2:0.17535) :0.24657, SETD7:0.43372) :0.01694, ( ( MLL:0.31117, MLL4:0.31609) :0.05423, SETD8:0.39677) :0.03148) :0.00684) :0.00558) :0.00421) :0.00550, ( ( ( ( MECOM:0.23499, PRDM16:0.22172) :0.19790, ( PRDM13:0.40625, PRDM8:0.41523) :0.01377) :0.01047, ( METTL20:0.41561, PRDM2:0.40118) :0.02407) :0.00891, ( ( ( PRDM1:0.41095, ( ( ( PRDM12:0.34755, PRDM6:0.35817) :0.02348, PRDM14:0.38137) :0.01014, PRDM4:0.40304) :0.01522) :0.00630, ( ( PRDM15:0.36547, PRDM5:0.38056) :0.03066, ( PRDM7:0.13090, PRDM9:0.11910) :0.29272) :0.00897) :0.00944, ( PRDM10:0.41440, PRDM11:0.41339) :0.00558) :0.02345) :0.00880) :0.00378, ( MLL5:0.34249, SETD5:0.34753) :0.10101) :0.00319, ( DOT1L:0.43970, ( ( FBL:0.43564, ( PCMT1:0.41513, ( SETD1A:0.30089, SETD1B:0.30309) :0.09786) :0.01938) :0.00301, ( MLL2:0.34090, MLL3:0.34348) :0.05345) :0.01186) :0.00212, ( SUV420H1:0.28698, SUV420H2:0.27795) :0.16293);

Spindlin domains

( ( SPIN1:0.05966, SPIN3:0.09538) :0.01442, ( SPIN2A:0.00390, SPIN2B:0.00000) :0.15225, SPIN4:0.19320);

WD40 repeat

( ( ( ( ( ( ( ( ( ( ( ( ( A6NM71:0.19599, WDR45:0.20470) :0.09963, WDR45B:0.29608) :0.08691, ( WIPI1:0.23323, WIPI2:0.23314) :0.16096) :0.05462, ( HPS5:0.42495, ( Q6ZS54:0.07930, TECPR2:0.06531) :0.34740) :0.02830) :0.00738, ( ( ( ( ( B3KP68:0.02958, IFT172:0.01983) :0.40428, ( H3BRJ5:0.08519, IFT80:0.08212) :0.34677) :0.01950, ( ( ( ( B4DGB7:0.10634, ( FLJ00025:0.01620, IFT122:0.01417) :0.08590) :0.33152, ( B4E286:0.00099, WDR19:-0.00021) :0.43697) :0.00625, ( B4DX09:0.00715, WDR11:-0.00715) :0.43568) :0.00117, WDR35:0.44480) :0.00621) :0.00259, ( NOL10:0.43979, ( WDR4:0.40993, WDR87:0.39832) :0.01255) :0.01757) :0.00463, ( ( C2ORF44:0.45495, ( RIC1:0.42645, WDPCP:0.44085) :0.01431) :0.01021, ( ( CFAP43:0.40442, WRAP73:0.39775) :0.03042, ( ( CIRH1A:0.01057, UTP4:-0.01057) :0.26437, UTP4B:0.22739) :0.15541) :0.01526) :0.00324) :0.00174) :0.00345, ( ( ( ( ( ARPC1A:0.15819, ARPC1B:0.15532) :0.26205, TULP4:0.42618) :0.01479, ( B4DT22:0.02871, PPWD1:0.02811) :0.42170) :0.00791, ( ( CHAF1B:0.38203, HIRA:0.38363) :0.04882, TBL2:0.42406) :0.01183) :0.00567, ( ( ( ( ( B4E018:0.06432, WDR74:0.07068) :0.34127, TBC1D31:0.43230) :0.01525, ( CFAP57:0.41726, WDR43:0.42173) :0.02215) :0.00643, ( ( IFT140:0.41881, PAK1IP1:0.40262) :0.01842, NEDD1:0.43401) :0.01328) :0.00169, ( ( ( Q9H8N9:0.00036, WDFY1:-0.00036) :0.19830, WDFY2:0.19595) :0.22661, WDR75:0.43841) :0.01209) :0.00368) :0.00262) :0.00142, ( ( ( ( ( ( B3KXN4:0.00113, WDR1:0.00063) :0.20232, B4DZX5:0.20358) :0.19099, NUP214:0.41605) :0.02208, ( B4E3M9:0.05032, BCAS3:0.04158) :0.40645) :0.01139, ( ( LYST:0.39074, WDR73:0.41613) :0.01794, WDR70:0.42844) :0.01302) :0.00482, ( ( ( ( B4DGE3:-0.00339, SEC31B:0.01476) :0.21084, SEC31A:0.22467) :0.20565, ( ( ( ( ( ( ( B4DMH3:0.00480, CORO1C:-0.00252) :0.15714, ( CORO1B:0.07346, Q59F81:0.04849) :0.07712) :0.01779, CORO6:0.16560) :0.00886, CORO1A:0.17512) :0.10337, ( CORO2A:0.17112, CORO2B:0.17054) :0.11519) :0.08192, CORO7:0.35399) :0.00600, Q6ZW98:0.35243) :0.05427) :0.01648, ( ( DMWD:0.20530, WDR20:0.20771) :0.22659, EDC4:0.43492) :0.01149) :0.00762) :0.00284) :0.00084, ( ( ( ( ( B3KP80:0.00256, KCTD3:-0.00040) :0.20355, SHKBP1:0.20559) :0.24354, ( ( LLGL1:0.22912, LLGL2:0.22970) :0.14773, ( STXBP5L:0.17197, STXBP5:0.16774) :0.20385) :0.06098) :0.00826, ( PAN2:0.44184, WDR53:0.40732) :0.01742) :0.00659, ( ( FBXW12:0.44201, WDR91:0.42868) :0.01595, ( WDR72:0.34853, WDR7:0.33569) :0.09711) :0.00847) :0.00188) :0.00094, ( ( ( ( DDB2:0.41348, WDR64:0.41790) :0.02504, ( EIF2A:0.42370, EIF3B:0.42416) :0.03594) :0.00269, ( ( NBAS:0.39925, PREB:0.41130) :0.03107, ( Q8N7X6:0.35163, WDR49:0.33563) :0.09867) :0.01070) :0.00192, ( ( ( ( ( PPP2R2A:0.06095, PPP2R2D:0.05986) :0.02793, ( PPP2R2B:0.06394, PPP2R2C:0.06473) :0.02365) :0.10439, Q59GC6:0.19117) :0.11725, Q6ZP32:0.32295) :0.13007, ( Q8N797:0.11339, WDR17:0.12507) :0.29318) :0.01686) :0.00252) :0.00185, ( ( ( ( AMBRA1:0.42291, ( B4E068:0.18682, WRAP53:0.19616) :0.21323) :0.02271, ( ( ( ( ( B3KUA2:0.00923, TLE3:0.00937) :0.09175, ( ( B4DEF9:0.00629, ( B4E345:0.00247, TLE1:-0.00247) :0.00846) :0.05931, TLE4:0.06588) :0.03599) :0.05206, ( B4DE62:0.03566, TLE2:0.04726) :0.10225) :0.17653, Q59EY9:0.33100) :0.09577, RFWD3:0.44119) :0.00962) :0.00837, ( ( ( ( B3KVI6:0.01383, LRBA:-0.01062) :0.15720, NBEA:0.14845) :0.21809, ( ( ( B4DVX0:0.01445, NBEAL2:-0.01445) :0.22279, NBEAL1:0.22376) :0.14282, NSMAF:0.37265) :0.00570) :0.05341, ( ( WDF3:0.04066, WDFY3:0.01411) :0.33624, WDFY4:0.35214) :0.05767) :0.01384) :0.00290, ( ( ( B7Z6H0:0.00262, SCAP:0.00031) :0.40861, WDR54:0.40729) :0.02915, ( MIOS:0.43207, THOC6:0.39784) :0.02348) :0.00730) :0.00379) :0.00107, ( ( ( ( B4DDD4:0.07776, WDR27:0.08246) :0.34083, ( FBXW4:0.41335, FBXW8:0.42160) :0.01194) :0.01445, ( VPRBP:0.43447, WDR37:0.41978) :0.01648) :0.00551, ( ( ( ( ( ( ( B4DN30:0.05743, DCAF4:0.05227) :0.06312, DCAF4L1:0.11562) :0.01435, DCAF4L2:0.12771) :0.30738, NWD2:0.42207) :0.01402, ( ( DMXL1:0.21995, DMXL2:0.22669) :0.16977, WDR92:0.40662) :0.03040) :0.00562, ( ( FBXW5:0.43540, ( FBXW9:0.40893, WDR81:0.40050) :0.01014) :0.01788, ( LRRK2:0.41772, MED16:0.44545) :0.01573) :0.00671) :0.00053, ( ( DCAF12L1:0.06676, DCAF12L2:0.06499) :0.11804, DCAF12:0.19026) :0.26659) :0.00373) :0.00089) :0.00136, ( ( ( ( ( AAMP:0.40151, ( ( DKFZP779C159:0.00283, KIF21A:0.00177) :0.22040, KIF21B:0.22176) :0.19539) :0.01372, WDR46:0.44082) :0.00864, ( RRP9:0.40700, WDR66:0.42458) :0.02017) :0.00541, ( ( ( B3KRR8:0.00369, WDR6:-0.00075) :0.23320, B4DK45:0.23445) :0.19837, ( GTF3C2:0.43690, ( HERC1:0.37630, NUP43:0.41054) :0.01224) :0.00945) :0.00794) :0.00125, ( CFAP44:0.41208, DCAF7:0.40955) :0.03312) :0.00392) :0.00045, ( ( ( ( ( ( ( ( ( ( ( ( A6P4T4:0.00508, EML4-ALK:-0.00131) :0.00549, B6EXY3:0.00431) :0.00673, A6P4V4:-0.00608) :0.16334, EML4:0.15948) :0.11014, ( ( B3KXA3:0.00255, EML1:0.00113) :0.19920, ( ( B7Z2F5:0.03845, EML2:0.03859) :0.07400, ( B7Z872:0.09969, B7Z918:0.09988) :0.02044) :0.08517) :0.07339) :0.02170, ( B4DL97:0.05251, EML3:0.05016) :0.23941) :0.12143, ( ( EML5:0.12612, EML6:0.12516) :0.24748, THOC3:0.37474) :0.01937) :0.02300, ( ( ( ( ( B4E1H5:-0.00073, CDC20:0.00073) :0.04208, Q2VIM1:0.04564) :0.27443, FZR1:0.32015) :0.03459, CDC20B:0.36376) :0.06893, ( B4E383:0.05144, ERCC8:0.05236) :0.36590) :0.01070) :0.00439, ( ( ( ( B4E2R3:0.09408, MLST8:0.11371) :0.27792, ELP2:0.41424) :0.01052, PRPF4:0.41017) :0.01458, ( BUB3:0.32893, RAE1:0.33876) :0.09452) :0.00675) :0.00252, ( ( ( ( ( B3KMW5:0.00404, WDR3:-0.00404) :0.42113, ( ( EIF3I:0.38888, STRAP:0.38651) :0.00967, UTP15:0.41483) :0.01348) :0.00625, ( ( ( GEMIN5:0.38483, WDR61:0.35287) :0.02545, WDSUB1:0.41275) :0.00266, ( TBL3:0.39295, ( WDR38:0.33694, WDR86:0.36688) :0.01314) :0.01698) :0.01064) :0.00548, ( ( ( B4DYK8:0.04841, WDR97:0.05199) :0.36562, ( PWP2:0.20216, Q59FM2:0.17758) :0.21800) :0.00823, ( WSB1:0.25729, WSB2:0.25756) :0.15581) :0.00778) :0.00546, ( ( ( CFAP52:0.40760, ( MAPKBP1:0.31335, WDR62:0.31281) :0.08255) :0.03133, ( WDR18:0.40917, WDR36:0.41258) :0.02506) :0.00504, ( DCAF13:0.42565, ( GNB1L:0.38044, NWD1:0.39632) :0.02210) :0.01611) :0.00258) :0.00317) :0.00112, ( ( ( ( ( ( ( ( A8MWR8:0.09797, SEC13:0.12883) :0.22721, SEH1L:0.36857) :0.05121, ( RBBP5:0.41351, WDR33:0.40991) :0.01392) :0.00833, ( ( B4E0E6:0.00291, DTL:0.00291) :0.41190, DCAF5:0.42079) :0.01470) :0.00503, ( KATNB1:0.41545, ( NUP37:0.40160, WDHD1:0.41128) :0.01968) :0.01110) :0.00528, ( ( ( B4DTI1:-0.01954, GRWD1:0.02486) :0.37746, ( RBBP4:0.06355, RBBP7:0.06351) :0.33629) :0.02019, ( BRWD1:0.23583, ( BRWD3:0.23125, PHIP:0.23102) :0.00470) :0.17900) :0.01180) :0.00482, ( ( ( B4DVM5:0.05661, WDR24:0.05885) :0.36345, PEX7:0.38687) :0.01489, ( DPH7:0.41974, WDR59:0.41654) :0.02361) :0.01021) :0.00438, ( ( ( ( ( ( B4DVD2:0.07277, GNB2L1:0.08107) :0.15670, B4DWC6:0.23201) :0.13491, WDR48:0.42071) :0.01251, ( ( ( COPA:0.39101, COPB2:0.39155) :0.02132, ( ( POC1A:0.20608, POC1B:0.21652) :0.11242, Q6ZW40:0.32744) :0.05323) :0.01827, PLAA:0.43715) :0.00375) :0.00749, ( WDR31:0.41330, WDR41:0.43138) :0.00923) :0.00689, ( ( ( CDRT1:0.06079, FBXW10:0.05756) :0.16337, Q59EB2:0.22408) :0.19781, TSSC1:0.41803) :0.02706) :0.00381) :0.00246) :0.00127, ( ( ( ( AAAS:0.00368, B4DDU7:0.00217) :0.43512, ( WDR77:0.38904, WDR90:0.37704) :0.02197) :0.01143, ( ( B4DVQ7:0.07250, WDR13:0.09771) :0.32295, DCAF10:0.42018) :0.02014) :0.00519, ( ( BOP1:0.42861, ( CDC40:0.40982, WDR25:0.41555) :0.01395) :0.01001, ( ( ( DCAF11:0.07938, Q59GN6:0.07627) :0.24148, H0YL77:0.33441) :0.09089, RPTOR:0.42585) :0.02229) :0.00618) :0.00430) :0.00076, ( ( ( ( ( ( ( AHI1:0.40130, WDR82:0.37506) :0.03193, ( ( ( B7Z2P6:0.00203, DCAF8:-0.00036) :0.15904, ( DCAF8L1:0.09869, DCAF8L2:0.09965) :0.06455) :0.23254, ( DCAF6:0.39601, WDTC1:0.39276) :0.00502) :0.04073) :0.00164, ( WDR44:0.40029, WDR83:0.35527) :0.03242) :0.01161, ( ( B4DNL1:-0.00363, PWP1:0.00363) :0.42075, LRWD1:0.44242) :0.01277) :0.00198, ( ( EED:0.42523, WDR76:0.43871) :0.00562, ( PALB2:0.43169, WDR89:0.42102) :0.01464) :0.01355) :0.00171, ( ( ( ( ( ( B4DPZ3:0.01412, DYNC1I2:0.01445) :0.00174, B4DX93:0.00613) :0.08999, DYNC1I1:0.10865) :0.30047, ( ( DNAI1:0.37465, WDR78:0.37357) :0.03257, WDR34:0.39929) :0.00653) :0.01937, ( DNAI2:0.37957, WDR63:0.39068) :0.04467) :0.01932, ( ( Q9Y6S1:0.03059, TLE6:0.03453) :0.37107, WDR60:0.41536) :0.03766) :0.00595) :0.00426, ( ( ( ( ( ( ( ( ( ( APAF1:0.38443, DAW1:0.36738) :0.01812, CSTF1:0.41112) :0.01287, ( ( ( DKFZP434D199:0.07977, SNRNP40:0.09346) :0.27479, WDR26:0.41317) :0.01004, ( ( PAFAH1B1:0.36051, ( WDR5B:0.07428, WDR5:0.07421) :0.26255) :0.01033, SMU1:0.39458) :0.02006) :0.00695) :0.00182, WDR88:0.41658) :0.00436, ( ( ( ( B4E074:0.00110, NLE1:0.00107) :0.00847, B4E303:0.01076) :0.38001, ( ( ( ( ( GNB1:0.04553, GNB4:0.04565) :0.00324, GNB2:0.04970) :0.04388, GNB3:0.09509) :0.14002, GNB5:0.24491) :0.13609, SPAG16:0.39576) :0.01277) :0.00607, WDR47:0.42413) :0.01224) :0.00333, ( ( ( ( BTRC:0.08136, FBXW11:0.07915) :0.29724, ( FBXW7:0.06995, Q53F40:0.07040) :0.30417) :0.02436, FBXW2:0.40974) :0.02740, ( PIK3R4:0.41642, WDR12:0.39446) :0.02518) :0.00374) :0.00073, ( ( DKFZP451A177:0.00547, ZNF106:-0.00304) :0.42524, TRAF7:0.42429) :0.01771) :0.00158, ( ( ( ( ( B7Z475:-0.00641, TBL1XR1:0.00641) :0.06013, ( TBL1X:0.04446, TBL1Y:0.04175) :0.02600) :0.32034, CIAO1:0.36726) :0.02291, ( ( STRN3:0.18112, STRN:0.18299) :0.05937, STRN4:0.23401) :0.18763) :0.00531, ( PLRG1:0.41162, ( PRPF19:0.40837, ( TAF5L:0.30796, TAF5:0.30834) :0.09896) :0.00834) :0.00738) :0.00813) :0.00255, ( ( ( ( ATG16L1:0.00344, Q9NWG8:0.01275) :0.25871, Q8TCI4:0.23490) :0.11177, ( ATG16L2:0.18566, FLJ00012:0.16049) :0.19150) :0.05598, ( ( Q59EZ2:0.00688, TEP1:0.00047) :0.37045, WDR55:0.39349) :0.02789) :0.00450) :0.00338, ( ( DENND3:0.43279, UTP18:0.42873) :0.01247, ( PAAF1:0.40268, RFWD2:0.41875) :0.01927) :0.01205) :0.00286) :0.00102);

YEATS

((MLLT1:0.23658,MLLT3:0.23569):0.22518,YEATS2:0.36660,YEATS4:0.35586);