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Chemical Probes
Chemical Probes
Potent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories.
SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. To acquire a sample, follow the links on the webpage of your desired chemical probe. You can sort the table by clicking the column headers.
The SGC probes set is complemented by the donated probe set
Name | Structures | Protein family | Specific Targets | Control |
In Vivo Activity*![]() |
Added |
---|---|---|---|---|---|---|
BI-1935 |
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Hydrolase | EPHX2 | BI-2049 | Yes | 05/18 |
JNJ-42396302 |
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Phosphodiesterase | PDE10A | JNJ-40573663 | Yes | 09/21 |
BAY-678 |
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Protease | ELANE | BAY-677 | Yes | 05/18 |
JNJ-9350 |
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Oxidase | SMOX | JNJ-4545 | Yes | 09/22 |
A-1211212 |
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Regulator protein | BCL2 | A-1210227 | Yes | 11/19 |
BAY-069 |
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Amino acid transaminase | BCAT1, BCAT2 | BAY-771 | Yes | 09/20 |
ERKi |
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Kinase | MAPK3, MAPK1 | ERKi-NC | Yes | 05/18 |
BAY-386 |
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GPCR | F2R | BAY-448 | Yes | 05/18 |
BAY1125976 |
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Kinase | AKT1/2 | BAY-940 | Yes | 11/21 |
BI-1950 |
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Integrin | ITGAL | BI-9446 | Yes | 11/18 |
MSD-CYP11B2 |
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Cytochrome P450 | CYP11B2 | MSD-CYP11B2 Negative control | Yes | 06/19 |
MRIA9 |
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Kinase | SIK1, SIK2, SIK3 | MR7 | Yes | 08/21 |
UNC1999 |
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Methyltransferase | EZH2 | UNC2400 | Yes | 05/13 |
MRK-560 |
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Protease | Gamma secretase complex | GSI-NC | Yes | 05/18 |
8RK64 |
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Regulator protein | UCHL1 | JYQ88 | Yes | 09/21 |
T-26c |
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Protease | MMP13 | T-26f | Yes | 05/18 |
CCT369260 |
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Transcription factor | BCL6 | CCT393732 | Yes | 09/22 |
A-192621 |
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GPCR | EDNRB | A-1806262 | Yes | 03/19 |
MSD-M1PAM |
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GPCR | CHRM1 | MSD-M1PAM-NC | Yes | 08/19 |
TP-030-1 |
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Kinase | RIPK1 | TP-030n | Yes | 09/20 |
BAY-3153 |
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GPCR | CCR1 | BAY-173 | Yes | 02/21 |
A-485 |
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Transferase | EP300, CREBBP | A-486 | Yes | 05/18 |
Borussertib |
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Kinase | AKT1, AKT2 | RL2578 | Yes | 10/21 |
BI 639667 |
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GPCR | CCR1 | BI-9307 | Yes | 11/18 |
DDR-TRK-1 |
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Kinase | DDR, TRK | DDR-TRK-1N | Yes | 08/18 |
PPTN |
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GPCR | P2RY14 | PPTN-NC | Yes | 06/19 |
MRL-650 |
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GPCR | CNR1 | MRL-CB1-NC | Yes | 05/18 |
GSK864 |
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Dehydrogenase | IDH1 | GSK990 | Yes | 11/15 |
PF-04457845 |
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Hydrolase | FAAH | PF-04875474 | Yes | 05/18 |
JNJ-6204 |
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Kinase | CSNK1D/CSNK1E | JNJ-0293 | Yes | 09/22 |
TP-024 |
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GPCR | GPR52 | TP-024n | Yes | 11/18 |
UNC0642 |
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Methyltransferase | EHMT2/G9a, EHMT1/GLP | Yes | 08/12 | |
MU1700 |
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Kinase | ALK1, ALK2 | MU1700NC | Yes | 02/22 |
Ogerin |
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GPCR | GPR68 | ZINC32547799 | Yes | 06/20 |
BI 207127 |
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RNA polymerase | HCV NS5B | BI-7656 | Yes | 11/20 |
TP-004 |
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Protease | METAP2 | TPn-004 | Yes | 05/18 |
MSC-4381 |
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Monocarboxylate transporter | SLC16A3 | MSC-0516 | Yes | 09/21 |
BAY-899 |
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GPCR | LHCGR | BAY-897 | Yes | 01/20 |
GSK2801 |
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Bromodomains | BAZ2A, BAZ2B | GSK8573 | Yes | 12/14 |
BAY-826 |
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Kinase | TIE1, TEK, DDR1, DDR2 | BAY-309 | Yes | 05/18 |
GSK973 |
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Bromodomains | BRD2, BRD3, BRD4, BRDT | GSK943 | Yes | 02/21 |
(R)-9s |
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GPCR | ADRA1D | (S)-9s | Yes | 05/18 |
TP-051 |
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GPCR | FFAR1 | TP-051n | Yes | 09/22 |
TP-020 |
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Transferase | MGAT2 | TP-020n | Yes | 11/18 |
BI-9564 |
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Bromodomains | BRD9, BRD7 | Yes | 04/15 | |
PF-04418948 |
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GPCR | PTGER2 | PF-04475866 | Yes | 05/18 |
JNJ-54119936 |
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Nuclear hormone receptor | RORC | JNJ-53721590 | Yes | 09/21 |
TP-472 |
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Bromodomains | BRD9, BRD7 | TP-472N | Yes | 06/16 |
A-079 |
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Ion channel | TRPA1 | A-226 | Yes | 11/18 |
BAY 1816032 |
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Kinase | BUB1 | BAY-283 | Yes | 10/22 |
UCSF924 |
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GPCR | DRD4 | UCSF924NC | Yes | 04/19 |
A-1155463 |
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Regulator protein | BCL2L1 | A-1107969 | Yes | 11/19 |
MU1742 |
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Kinase | CK1δ, CK1ε | MU2027 | Yes | 10/22 |
BAY-390 |
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Ion channel | TRPA1 | BAY-9897 | Yes | 09/20 |
ABT-724 |
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GPCR | DRD4 | A-769 | Yes | 05/18 |
GSK046 |
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Bromodomains | BRD2, BRD3, BRD4, BRDT | Yes | 02/21 | |
GSK484 |
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Arginine deiminases | PAD4 | GSK106 | Yes | 03/15 |
GNE-2256 |
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Kinase | IRAK4 | GNE-6689 | Yes | 11/21 |
BAY-1797 |
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Ion channel | P2X4 | BAY-207 | Yes | 11/18 |
GSM1 |
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Protease | Gamma secretase complex | GSM-NC | Yes | 05/18 |
TP-040 |
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Hydrolase | OGA | TP-040n | Yes | 09/21 |
BAY-876 |
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Solute carriers | SLC2A1 | BAY-588 | Yes | 05/18 |
SAFit2 |
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Isomerase | FKBP5 | ddSAFit2 | Yes | 09/22 |
BAZ2-ICR |
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Bromodomains | BAZ2A, BAZ2B | Yes | 05/14 | |
TP-030-2 |
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Kinase | RIPK1 | TP-030n | Yes | 09/20 |
BAY-7598 |
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Protease | MMP12 | BAY-694 | Yes | 05/18 |
GSK778 |
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Bromodomains | BRD2, BRD3, BRD4, BRDT | Yes | 02/21 | |
BAY-598 |
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Methyltransferase | SMYD2 | BAY-369 | Yes | 04/15 |
BAY-707 |
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Hydrolase | NUDT1 | BAY-604 | Yes | 05/18 |
JNJ-65355394 |
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Hydrolase | OGA | JNJ-73924149 | Yes | 11/21 |
BI 653048 |
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Nuclear hormone receptor | NR3C1 | BI-3047 | Yes | 11/18 |
THPP-1 |
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Phosphodiesterase | PDE10A | THPP-1-NC | Yes | 06/19 |
Skepinone-L |
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Kinase | MAPK14 | FM-743 | Yes | 01/20 |
MRL-SYKi |
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Kinase | SYK | MRL-SYKi-NC | Yes | 05/18 |
A-446 |
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Hydrolase | GLS | A-426 | Yes | 07/21 |
ABT-546 |
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GPCR | EDNRA | A-545 | Yes | 05/18 |
JNJ-39758979 |
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GPCR | HRH4 | JNJ-39668551 | Yes | 09/22 |
L-Moses |
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Bromodomains | KAT2A, KAT2B | D-Moses | Yes | 10/17 |
BI-1230 |
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Protease | HCV NS3 | BI-1675 | Yes | 03/19 |
BAY-474 |
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Kinase | MET | BAY-827 | Yes | 05/18 |
BAY-6672 |
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GPCR | PTGFR | BAY-403 | Yes | 11/20 |
BI-9627 |
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Solute carriers | SLC9A1 | BI-0054 | Yes | 05/18 |
GSK6853 |
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Bromodomains | BRPF1 | GSK9311 | Yes | 01/17 |
BI-2545 |
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Phosphodiesterase | ENPP2 | BI-3017 | Yes | 11/18 |
BAY-549 |
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Kinase | ROCK1, ROCK2 | BAY-4900 | Yes | 06/19 |
BAY-179 |
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Complex I | BAY-070 | Yes | 01/20 | |
JQ1 |
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Bromodomains | BRD2, BRD3, BRD4, BRDT | (-)-JQ1 | Yes | 06/10 |
CRTH2 antagonist |
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GPCR | PTGDR2 | CRTH2 negative control | Yes | 05/18 |
BI 605906 |
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Kinase | IKBKB | BI-5026 | Yes | 06/21 |
BAY-678 |
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Protease | ELANE | BAY-677 | Yes | 10/15 |
KISS1-305 |
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GPCR | KISS1R | KISS1-543 | Yes | 05/18 |
BI-2081 |
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GPCR | FFAR1 | BI-0340 | Yes | 09/22 |
TP-021 |
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Transcription factor | BCL6 | TP-021n | Yes | 11/18 |
M4K2234 |
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Kinase | ALK1, ALK2 | M4K2234NC | Yes | 02/22 |
WM-1119 |
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Transferase | KAT6A, KAT6B | WM-2474 | Yes | 06/20 |
BI-2540 |
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Reverse transcriptase | HIV NNRT | BI-2439 | Yes | 11/20 |
PF-05105679 |
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Ion channel | TRPM8 | PF-05257137 | Yes | 05/18 |
PFI-653 |
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Hydrolase | VNN1 | PFI-653-N | Yes | 09/21 |
BI-4394 |
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Protease | MMP13 | BI-4395 | Yes | 11/18 |
MLi-2 |
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Kinase | LRRK2 | MLi-2-NC | Yes | 05/19 |
BAY-985 |
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Kinase | TBK1, IKBKE | BAY-440 | Yes | 01/20 |
CS640 |
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Kinase | CAMK1 | CS640s | Yes | 01/23 |
BI 665915 |
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Lipoxygenase | ALOX5AP | BI-0153 | Yes | 05/18 |
GSK620 |
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Bromodomains | BRD2, BRD3, BRD4, BRDT | Yes | 02/21 | |
ABT-100 |
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Transferase | FNTB | A-108 | Yes | 05/18 |
TP-050 |
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Ion channel | GRIN2A | TP-050n | Yes | 09/22 |
BAY-784 |
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GPCR | GNRHR | BAY-786 | Yes | 11/18 |
NVS-MALT1 |
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Protease | MALT1 | NVS-MALT1-C | Yes | 02/20 |
NVS-CECR2-1 |
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Bromodomains | CECR2 | NVS-CECR2-C | No | 06/15 |
T3-CLK |
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Kinase | CLK1, CLK2, CLK3, CLK4 | T3-CLK-N | No | 04/19 |
PFI-4 |
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Bromodomains | BRPF1 | No | 12/14 | |
BAY-805 | USP (ubiquitin specific protease) | USP21 | BAY-728 | No | 10/22 | |
GSK789 |
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Bromodomains | BRD2, BRD3, BRD4, BRDT | GSK791 | No | 02/21 |
MS049 |
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Methyltransferase | CARM1, PRMT6 | MS049N | No | 06/15 |
GSK-LSD1 |
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Lysine Demethylase | KDM1A/LSD1 | No | 03/14 | |
FS-694 |
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Kinase | MAPK14 | FM-743 | No | 01/20 |
PFI-2 |
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Methyltransferase | SETD7 | (S)-PFI-2 | No | 05/13 |
BAY-299 |
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Bromodomains | TAF1, BRD1 | BAY-364 | No | 06/16 |
SGC-CAMKK2-1 |
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Kinase | CAMKK1, CAMKK2 | SGC-CAMKK2-1N | No | 01/20 |
A-366 |
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Methyltransferase | EHMT1/GLP, EHMT2/G9a | No | 06/13 | |
MRK-990 |
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Methyltransferase | PRMT9, PRMT5 | MRK-990-NC | No | 10/22 |
BI 99179 |
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Synthase | FASN | BI 99990 | No | 05/18 |
A-196 |
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Methyltransferase | SUV420H1, SUV420H2 | A-197, SGC2043 | No | 07/15 |
SR-318 |
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Kinase | MAPK14 | SR-321 | No | 01/20 |
LLY-507 (Multiple Off-target Effects) |
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Methyltransferase | SMYD2 | SGC705 | No | 11/13 |
UNC0638 |
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Methyltransferase | EHMT2/G9a, EHMT1/GLP | UNC0737 | No | 06/10 |
BI-1942 |
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Protease | CMA1 | No | 06/21 | |
NI-57 |
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Bromodomains | BRPF1, BRD1, BRPF3 | No | 12/14 | |
BAY-885 |
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Kinase | MAPK7 | BAY-693 | No | 11/18 |
TP-008 |
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Kinase | ACVR1B, TGFBR1 | Al11 | No | 06/19 |
PFI-6 |
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YEATS | MLLT1, MLLT3 | PFI-6N | No | 06/20 |
SGC0946 |
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Methyltransferase | DOT1L | SGC0649 | No | 08/12 |
GSK591 |
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Methyltransferase | PRMT5 | SGC2096 | No | 07/15 |
T3-CLK |
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Kinase | CLK1, CLK2, CLK3, CLK4 | T3-CLK-N | No | 05/19 |
GSK343 |
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Methyltransferase | EZH2 | No | 08/12 | |
SGC-UBD253 |
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UBD (ubiquitin binding domain) | HDAC6 | SGC-UBD253N | No | 01/22 |
SR-302 |
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Kinase | DDR1, DDR2, MAPK11, MAPK14 | SR-301 | No | 06/20 |
NVS-MLLT-1 |
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YEATS | MLLT1, MLLT3 | NVS-iMLLT-C | No | 03/20 |
IOX2 (requires >>> 1 microM for cell assays) |
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2OG | PHD2 | No | 02/12 | |
BTZO-1 |
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Cytokine | MIF | BTZO-4 | No | 05/18 |
NVS-BPTF-1 |
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Bromodomains | BPTF | NVS-BPTF-C | No | 02/19 |
PFI-1 |
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Bromodomains | BRD2, BRD3, BRD4, BRDT | No | 11/11 | |
PFI-7 |
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E3 ligase | GID4 | PFI-7N | No | 09/21 |
BAY-3827 |
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Kinase | PRKAA1, RPS6KA1 | BAY-974 | No | 01/20 |
PFI-3 |
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Bromodomains | SMARCA2, PBRM1, SMARCA4 | PFI-3oMet | No | 11/13 |
OF-1 |
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Bromodomains | BRPF1, BRD1, BRPF3 | No | 07/14 | |
BAY-293 |
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Nucleotide exchange factor | SOS1 | BAY-294 | No | 04/19 |
SGC-CLK-1 |
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Kinase | CLK1, CLK2, CLK4 | SGC-CLK-1N | No | 02/20 |
IPP/CNRS-A017 |
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Dehydrogenase | DHODH | IPP/CNRS-A019 | No | 10/19 |
MRK-952 |
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Hydrolase | NUDT5 | MRK-952-NC | No | 10/22 |
Homer |
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WD40 repeat | WDR5 | nc_WDR5 and nc_VHL | No | 07/21 |
OICR-9429 |
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WD40 repeat | WDR5 | OICR-0547 | No | 05/14 |
UNC1215 |
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Methyl Lysine Binder | L3MBTL3 | UNC1079 | No | 08/12 |
NVS-PAK1-1 |
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Kinase | PAK1 | NVS-PAK1-C | No | 06/16 |
A-1596586 |
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Ion channel | CFTR | A-1596584 | No | 06/19 |
IOX1 (tool compound) |
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2OG | Pan-KDM | No | 01/12 | |
SGC-PIKFYVE-1 |
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Kinase | PIKfyve | SGC-PIKFYVE-1N | No | 10/22 |
(R)-ZINC-3573 |
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GPCR | MRGPRX2 | (S)-ZINC-3573 | No | 06/20 |
LP99 |
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Bromodomains | BRD9, BRD7 | 2S,3R-enantiomer | No | 12/14 |
BAY-091 |
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Kinase | PIP4K2A | BAY-0361 | No | 10/21 |
NR162 |
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Kinase | CASK | NR187 | No | 09/20 |
SGC707 |
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Methyltransferase | PRMT3 | XY1 | No | 06/14 |
MU1210 |
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Kinase | CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 | MU140 | No | 05/19 |
I-CBP112 |
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Bromodomains | CREBBP, EP300 | No | 03/13 | |
I-BRD9 |
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Bromodomains | BRD9 | No | 05/15 | |
SGC-CK2-1 |
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Kinase | CSNK2A1, CSNK2A2 | SGC-CK2-1N | No | 06/20 |
GSK-J1 use pro-drug GSK-J4 for cell assays |
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Lysine Demethylase | KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B | GSK-J2 (GSK-J5) | No | 07/12 |
SGC-CBP30 |
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Bromodomains | CREBBP, EP300 | BDOIA513 | No | 03/13 |
MS023 |
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Methyltransferase | PRMT1, PRMT3, CARM1, PRMT6, PRMT8 | MS094 | No | 07/15 |
TP-008 |
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Kinase | ALK4, ALK5 | AI11 | No | 05/19 |
Bromosporine (BSP) (tool compound) |
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Bromodomains | pan-Bromodomain | No | 01/13 | |
CK156 |
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Kinase | STK17A, DRAK1 | CKJB71 | No | 10/21 |
TP-064 |
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Methyltransferase | CARM1 | TP-064N | 06/16 | |
SGC-AAK1-1 |
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Kinase | AAK1, BMP2K, BIKE | SGC-AAK1-1N | 02/18 | |
SGC-STK17B-1 |
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Kinase | STK17B, DRAK2 | SGC-STK17B-1N | 02/20 | |
FM-381 |
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Kinase | JAK3 | FM-479 | 02/17 | |
TP-238 |
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Bromodomains | CECR2, BPTF | TP-422 | 09/18 | |
A-485 |
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Lysine acetyltransferase | CREBBP, EP300 | A-486 | 10/17 | |
GSK8814 |
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Bromodomains | ATAD2, ATAD2B | GSK8815 | 01/17 | |
SGC-SMARCA-BRDVIII |
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Bromodomains | PB1(5), SMARCA2/4 | SGC-BRDVIII-NC | 12/20 | |
TH-257 |
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Kinase | LIMK1, LIMK2 | TH-263 | 07/17 | |
UNC6934 |
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Methyl Lysine Binder | NSD2-PWWP1 | UNC7145 | 06/19 | |
LLY-283 |
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Methyltransferase | PRMT5 | LLY-284 | 07/16 | |
MRK-740 |
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Methyltransferase | PRDM9 | MRK-740-NC | 06/18 | |
MSC1186 |
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MSC5360 | 01/23 | |||
PFI-5 |
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Methyltransferase | SMYD2 | PFI-5N | 07/17 | |
SGC-GAK-1 |
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Kinase | GAK | SGC-GAK-1N | 02/18 | |
GSK4027 |
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Bromodomains | KAT2A, KAT2B | GSK4028 | 06/17 | |
T-26c |
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Protease | MMP13 | T-26f | 06/16 | |
BI01383298 |
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Solute carriers | SLC13A5 | BI01372674 | 01/18 | |
BAY-850 |
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Bromodomains | ATAD2 | BAY-460 | 01/17 | |
VinSpinIn |
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Spindlin domains | Spin1 | VinSpinIC | 09/18 | |
SGC6870 |
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Methyltransferase | PRMT6 | SGC6870N | 06/19 | |
BI-9321 |
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Methyl Lysine Binder | NSD3 | BI-9466 | 07/18 | |
SKI-73 |
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Methyltransferase | CARM1 | SKI-73N | 07/17 | |
A-395 |
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WD40 repeat | EED | A-395N | 07/16 | |
SGC3027 |
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Methyltransferase | PRMT7 | SGC3027N | 03/18 | |
BAY-6035 |
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Methyltransferase | SMYD3 | BAY-444 | 06/17 |
Chemical Handles
This versatile modality can be used to develop tools for proximity-inducing chemistry, tracers for target engagement assays, PROTACs, chemical inducers of degradation, and pull-down reagents. Handles bind their target with Kd < 1 micromolar. Their selectivity and cell activity has not been determined.
Chemical Handle | Chemical Probe | Structures | Protein family | Specific Targets | Control |
In Vivo Activity*![]() |
Added |
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PFI-E3H1 | PFI-7 |
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E3 ligase | GID4 | PFI-7N | No | 09/21 |
Please select a protein family