SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. SGC-developed probes are complemented by a growing set of donated high-quality chemical probes developed in industry and non-SGC laboratories. These are also available for unencumbered use.
The table below contains the entire collection of probes from SGC’s chemical probes program and donated chemical probes. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers.
| Name | Structures | Protein Family | Target Protein | Control | Cellular Usage | Added |
|---|---|---|---|---|---|---|
| OICR-41103 |
|
WD40 repeat | DCAF1 | OICR-41103N | 1 µM; not to exceed 5 µM | |
| SGC-CDKL2/AAK1/BMP2K-1 |
|
Kinase | CDKL2 | CDKL2/AAK1/BMP2K -1N | ≤1 µM | |
| TP-061 |
|
Helicases | Brr2 | TP-061N | 5 µM | |
| BI-1915 |
|
Protease | CTSS | BI-1920 | ||
| BI-113823 |
|
GPCR | BDKRB1 | BI-5832 | ||
| JNJ-54082730 |
|
Hydrolase | PDE2A | JNJ-54103985 | ||
| JNJ-3738 |
|
Kinase | CDK7 | JNJ-6240 | ||
| BAY-9835 |
|
Protease | ADAMTS7, ADAMTS12 | BAY-1880 | ||
| Bromosporine (BSP) |
|
Bromodomains | pan-Bromodomain | |||
| UNC1215 |
|
Methyl Lysine Binder | L3MBTL3 | UNC1079 | ||
| SGC0946 |
|
Methyltransferase | DOT1L | SGC0649 | ||
| UNC0642 |
|
Methyltransferase | EHMT2/G9a, EHMT1/GLP | |||
| GSK343 |
|
Methyltransferase | EZH2 | |||
| GSK-J1 |
|
Lysine Demethylase | KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B | GSK-J2 (GSK-J5) | ||
| IOX2 |
|
2OG | PHD2 | |||
| IOX1 |
|
2OG | Pan-KDM | |||
| PFI-1 |
|
Bromodomains | BRD2, BRD3, BRD4, BRDT | |||
| UNC0638 |
|
Methyltransferase | EHMT2/G9a, EHMT1/GLP | UNC0737 | ||
| (+)-JQ1 |
|
Bromodomains | BRD2, BRD3, BRD4, BRDT | (-)-JQ1 | ||
| MS023 |
|
Methyltransferase | PRMT1, PRMT3, CARM1, PRMT6, PRMT8 | MS094 | ||
| MS049 |
|
Methyltransferase | CARM1, PRMT6 | MS049N | ||
| NVS-CECR2-1 |
|
Bromodomains | CECR2 | NVS-CECR2-C | 1 µM | |
| I-BRD9 |
|
Bromodomains | BRD9 | |||
| BI-9564 |
|
Bromodomains | BRD9, BRD7 | |||
| BAY-598 |
|
Methyltransferase | SMYD2 | BAY-369 | ||
| GSK484 |
|
Arginine deiminases | PAD4 | GSK106 | ||
| GSK2801 |
|
Bromodomains | BAZ2A, BAZ2B | GSK8573 | ||
| LP99 |
|
Bromodomains | BRD9, BRD7 | 2S,3R-enantiomer | ||
| NI-57 |
|
Bromodomains | BRPF1, BRD1, BRPF3 | 1 µM | ||
| PFI-4 |
|
Bromodomains | BRPF1 | 1 µM | ||
| OF-1 |
|
Bromodomains | BRPF1, BRD1, BRPF3 | <5 µM | ||
| SGC707 |
|
Methyltransferase | PRMT3 | XY1 | ||
| BAZ2-ICR |
|
Bromodomains | BAZ2A, BAZ2B | |||
| OICR-9429 |
|
WD40 repeat | WDR5 | OICR-0547 | ||
| GSK-LSD1 |
|
Lysine Demethylase | KDM1A/LSD1 | |||
| LLY-507 (multiple off-targets) |
|
Methyltransferase | SMYD2 | SGC705 | ||
| PFI-3 |
|
Bromodomains | SMARCA2, PBRM1, SMARCA4 | PFI-3oMet | ||
| A-366 |
|
Methyltransferase | EHMT1/GLP, EHMT2/G9a | |||
| UNC1999 |
|
Methyltransferase | EZH2 | UNC2400 | ||
| (R)-PFI-2 |
|
Methyltransferase | SETD7 | (S)-PFI-2 | ||
| SGC-CBP30 |
|
Bromodomains | CREBBP, EP300 | BDOIA513 | ||
| I-CBP112 |
|
Bromodomains | CREBBP, EP300 | |||
| SGC3027 |
|
Methyltransferase | PRMT7 | SGC3027N | ||
| SGC-GAK-1 |
|
Kinase | GAK | SGC-GAK-1N | ||
| SGC-AAK1-1 |
|
Kinase | AAK1, BMP2K, BIKE | SGC-AAK1-1N | ||
| BI01383298 |
|
Solute carriers | SLC13A5 | BI01372674 | ||
| L-Moses |
|
Bromodomains | KAT2A, KAT2B | D-Moses | ||
| TH-257 |
|
Kinase | LIMK1, LIMK2 | TH-263 | ||
| SKI-73 |
|
Methyltransferase | CARM1 | SKI-73N | ||
| PFI-5 |
|
Methyltransferase | SMYD2 | PFI-5N | ||
| BAY-6035 |
|
Methyltransferase | SMYD3 | BAY-444 | ||
| GSK4027 |
|
Bromodomains | KAT2A, KAT2B | GSK4028 | ||
| FM-381 |
|
Kinase | JAK3 | FM-479 | ||
| BAY-850 |
|
Bromodomains | ATAD2 | BAY-460 | ||
| GSK8814 |
|
Bromodomains | ATAD2, ATAD2B | GSK8815 | ||
| GSK6853 |
|
Bromodomains | BRPF1 | GSK9311 | < 1 µM | |
| LLY-283 |
|
Methyltransferase | PRMT5 | LLY-284 | ||
| A-395 |
|
WD40 repeat | EED | A-395N | ||
| TP-472 |
|
Bromodomains | BRD9, BRD7 | TP-472N | ||
| TP-064 |
|
Methyltransferase | CARM1 | TP-064N | ||
| BAY-299 |
|
Bromodomains | TAF1, BRD1 | BAY-364 | ||
| NVS-PAK1-1 |
|
Kinase | PAK1 | NVS-PAK1-C | ||
| GSK864 |
|
Dehydrogenase | IDH1 | GSK990 | ||
| A-196 |
|
Methyltransferase | SUV420H1, SUV420H2 | SGC2043 | ||
| GSK591 |
|
Methyltransferase | PRMT5 | SGC2096 | ||
| MU1700 |
|
Kinase | ALK1, ALK2 | MU1700NC | ||
| M4K2234 |
|
Kinase | ALK1, ALK2 | M4K2234NC | 1 µM | |
| SGC-UBD253 |
|
UBD (ubiquitin binding domain) | HDAC6 | SGC-UBD253N | ||
| CK156 |
|
Kinase | STK17A, DRAK1 | CKJB71 | 5 µM | |
| PFI-7 |
|
E3 ligase | GID4 | PFI-7N | ||
| MRIA9 |
|
Kinase | SIK1, SIK2, SIK3 | MR7 | 10 µM | |
| Homer |
|
WD40 repeat | WDR5 | nc_WDR5 and nc_VHL | 1 µM | |
| SGC-SMARCA-BRDVIII |
|
Bromodomains | PB1(5), SMARCA2/4 | SGC-BRDVIII-NC | 10 µM | |
| NR162 |
|
Kinase | CASK | NR187 | 10 µM | |
| PFI-6 |
|
YEATS | MLLT1, MLLT3 | PFI-6N | ||
| SGC-CK2-1 |
|
Kinase | CSNK2A1, CSNK2A2 | SGC-CK2-1N | ||
| NVS-MLLT-1 |
|
YEATS | MLLT1, MLLT3 | NVS-iMLLT-C | 1 µM | |
| SGC-STK17B-1 |
|
Kinase | STK17B, DRAK2 | SGC-STK17B-1N | ||
| SGC-CLK-1 |
|
Kinase | CLK1, CLK2, CLK4 | SGC-CLK-1N | ||
| SGC-CAMKK2-1 |
|
Kinase | CAMKK1, CAMKK2 | SGC-CAMKK2-1N | ||
| SGC6870 |
|
Methyltransferase | PRMT6 | SGC6870N | ||
| UNC6934 |
|
Methyl Lysine Binder | NSD2-PWWP1 | UNC7145 | ||
| MU1210 |
|
Kinase | CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 | MU140 | 1 µM | |
| NVS-BPTF-1 |
|
Bromodomains | BPTF | NVS-BPTF-C | < 1 µM | |
| VinSpinIn |
|
Spindlin domains | Spin1 | VinSpinIC | 0.5 µM - 3 µM | |
| TP-238 |
|
Bromodomains | CECR2, BPTF | TP-422 | < 2 µM | |
| DDR-TRK-1 |
|
Kinase | DDR, TRK | DDR-TRK-1N | 5 µM | |
| BI-9321 |
|
Methyl Lysine Binder | NSD3 | BI-9466 | 0.5 µM - 20 µM | |
| MRK-740 |
|
Methyltransferase | PRDM9 | MRK-740-NC | 3 µM | |
| SGC-UBD1031 |
|
UBD (ubiquitin binding domain) | USP16/HDAC6 | SGC-UBD1031N | 10 µM | |
| UNC8732 |
|
Methyl Lysine Binder | NSD2 | UNC8884 | ||
| OICR11029 |
|
Transcription factor | BCL6 | OICR11600 | ||
| PFI-8 |
|
YEATS | YEATS | PFI-8N | ||
| JA310 |
|
Kinase | MST3, MST4 | JA262 | < 1 µM | |
| SGC-GSK3-1 |
|
Kinase | GSK3 | SGC-CDKL5/GSK3-1N | ||
| SGC-CDKL5_GSK3 |
|
Kinase | CDKL5, GSK3 | SGC-CDKL5/GSK3-1N | ||
| SGC-CAF382-1 |
|
Kinase | CDKL5 | SGC-CAF268-1N | ≤ 100 nM | |
| LIJTF500025 |
|
Kinase | LIMK1, LIMK2 | LIJTF500120 | < 1 µM | |
| JA397 |
|
Kinase | CDK14-18 | JA314 | < 1 µM | |
| SGC-PI5P4Kγ/MYLK4-1 |
|
Kinase | PI5P4K gamma, MYLK4 | SGC-PI5P4Kγ/MYLK4-1N | ||
| SGC-CK2-2 |
|
Kinase | CK2/CSNK2 | SGK-CK2-2N | ||
| MSC1186 |
|
Kinase | SRPK | MSC5360 | < 1 µM | |
| CS640 |
|
Kinase | CAMK1 | CS640s | < 1 µM | |
| MU1742 |
|
Kinase | CK1δ, CK1ε | MU2027 | ||
| BAY-805 |
|
USP (ubiquitin specific protease) | USP21 | BAY-728 | ||
| MRK-952 |
|
Hydrolase | NUDT5 | MRK-952-NC | ||
| MRK-990 |
|
Methyltransferase | PRMT9, PRMT5 | MRK-990-NC | ||
| SGC-PIKFYVE-1 |
|
Kinase | PIKfyve | SGC-PIKFYVE-1N | ||
| ABT-724 |
|
GPCR | DRD4 | A-769 | ||
| ERKi |
|
Kinase | MAPK3, MAPK1 | ERKi-NC | ||
| BAY-7598 |
|
Protease | MMP12 | BAY-694 | ||
| BI 99179 |
|
Synthase | FASN | BI 99990 | ||
| BAY-474 |
|
Kinase | MET | BAY-827 | ||
| (R)-9s |
|
GPCR | ADRA1D | (S)-9s | ||
| ABT-100 |
|
Transferase | FNTB | A-108 | ||
| BTZO-1 |
|
Cytokine | MIF | BTZO-4 | ||
| BAY-386 |
|
GPCR | F2R | BAY-448 | ||
| BAY-707 |
|
Hydrolase | NUDT1 | BAY-604 | ||
| A-485 |
|
Transferase | EP300, CREBBP | A-486 | ||
| BI-9627 |
|
Solute carriers | SLC9A1 | BI-0054 | ||
| TP-004 |
|
Protease | METAP2 | TPn-004 | ||
| PF-05105679 |
|
Ion channel | TRPM8 | PF-05257137 | ||
| PF-04418948 |
|
GPCR | PTGER2 | PF-04475866 | ||
| BI-1935 |
|
Hydrolase | EPHX2 | BI-2049 | ||
| GSM1 |
|
Protease | Gamma secretase complex | GSM-NC | ||
| MRK-560 |
|
Protease | Gamma secretase complex | GSI-NC | ||
| MRL-SYKi |
|
Kinase | SYK | MRL-SYKi-NC | ||
| MRL-650 |
|
GPCR | CNR1 | MRL-CB1-NC | ||
| CRTH2 antagonist |
|
GPCR | PTGDR2 | CRTH2 negative control | ||
| TP-021 |
|
Transcription factor | BCL6 | TP-021n | ||
| TP-020 |
|
Transferase | MGAT2 | TP-020n | ||
| BAY-784 |
|
GPCR | GNRHR | BAY-786 | ||
| BAY-1797 |
|
Ion channel | P2X4 | BAY-207 | ||
| BI-1950 |
|
Integrin | ITGAL | BI-9446 | ||
| BI 653048 |
|
Nuclear hormone receptor | NR3C1 | BI-3047 | ||
| BI 639667 |
|
GPCR | CCR1 | BI-9307 | ||
| BI-2545 |
|
Phosphodiesterase | ENPP2 | BI-3017 | ||
| BAY-885 |
|
Kinase | MAPK7 | BAY-693 | ||
| BI-4394 |
|
Protease | MMP13 | BI-4395 | ||
| A-079 |
|
Ion channel | TRPA1 | A-226 | ||
| BAY-678 |
|
Protease | ELANE | BAY-677 | ||
| BAY-876 |
|
Solute carriers | SLC2A1 | BAY-588 | ||
| T-26c |
|
Protease | MMP13 | T-26f | ||
| ABT-546 |
|
GPCR | EDNRA | A-545 | ||
| PF-04457845 |
|
Hydrolase | FAAH | PF-04875474 | ||
| KISS1-305 |
|
GPCR | KISS1R | KISS1-543 | ||
| A-1155463 |
|
Regulator protein | BCL2L1 | A-1107969 | ||
| A-1211212 |
|
Regulator protein | BCL2 | A-1210227 | ||
| IPP/CNRS-A017 |
|
Dehydrogenase | DHODH | IPP/CNRS-A019 | ||
| MSD-M1PAM |
|
GPCR | CHRM1 | MSD-M1PAM-NC | ||
| A-1596586 |
|
Ion channel | CFTR | A-1596584 | ||
| MSD-CYP11B2 |
|
Cytochrome P450 | CYP11B2 | MSD-CYP11B2 Negative control | ||
| THPP-1 |
|
Phosphodiesterase | PDE10A | THPP-1-NC | ||
| PPTN |
|
GPCR | P2RY14 | PPTN-NC | ||
| BAY-549 |
|
Kinase | ROCK1, ROCK2 | BAY-4900 | ||
| TP-008 |
|
Kinase | ACVR1B, TGFBR1 | Al11 | ||
| MLi-2 |
|
Kinase | LRRK2 | MLi-2-NC | ||
| UCSF924 |
|
GPCR | DRD4 | UCSF924NC | ||
| T3-CLK |
|
Kinase | CLK1, CLK2, CLK3, CLK4 | T3-CLK-N | ||
| BAY-293 |
|
Nucleotide exchange factor | SOS1 | BAY-294 | ||
| A-192621 |
|
GPCR | EDNRB | A-1806262 | ||
| BI-1230 |
|
Protease | HCV NS3 | BI-1675 | ||
| TP-024 |
|
GPCR | GPR52 | TP-024n | ||
| BI-2540 |
|
Reverse transcriptase | HIV NNRT | BI-2439 | ||
| BAY-390 |
|
Ion channel | TRPA1 | BAY-9897 | ||
| BAY-069 |
|
Amino acid transaminase | BCAT1, BCAT2 | BAY-771 | ||
| TP-030-2 |
|
Kinase | RIPK1 | TP-030n | ||
| TP-030-1 |
|
Kinase | RIPK1 | TP-030n | ||
| (R)-ZINC-3573 |
|
GPCR | MRGPRX2 | (S)-ZINC-3573 | ||
| Ogerin |
|
GPCR | GPR68 | ZINC32547799 | ||
| WM-1119 |
|
Transferase | KAT6A, KAT6B | WM-2474 | ||
| SR-302 |
|
Kinase | DDR1, DDR2, MAPK11, MAPK14 | SR-301 | ||
| NVS-MALT1 |
|
Protease | MALT1 | NVS-MALT1-C | ||
| BAY-3827 |
|
Kinase | PRKAA1, RPS6KA1 | BAY-974 | ||
| FS-694 |
|
Kinase | MAPK14 | FM-743 | ||
| Skepinone-L |
|
Kinase | MAPK14 | FM-743 | ||
| SR-318 |
|
Kinase | MAPK14 | SR-321 | ||
| BAY-179 |
|
Protease | Complex I | BAY-070 | ||
| BAY-899 |
|
GPCR | LHCGR | BAY-897 | ||
| BAY-985 |
|
Kinase | TBK1, IKBKE | BAY-440 | ||
| Borussertib |
|
Kinase | AKT1, AKT2 | RL2578 | ||
| BAY-091 |
|
Kinase | PIP4K2A | BAY-0361 | ||
| MSC-4381 |
|
Monocarboxylate transporter | SLC16A3 | MSC-0516 | ||
| PFI-653 |
|
Hydrolase | VNN1 | PFI-653-N | ||
| JNJ-54119936 |
|
Nuclear hormone receptor | RORC | JNJ-53721590 | ||
| JNJ-42396302 | Phosphodiesterase | PDE10A | JNJ-40573663 | |||
| TP-040 |
|
Hydrolase | OGA | TP-040n | ||
| 8RK64 |
|
Regulator protein | UCHL1 | JYQ88 | ||
| A-446 |
|
Hydrolase | GLS | A-426 | ||
| BI-1942 | Protease | CMA1 | ||||
| BI 605906 |
|
Kinase | IKBKB | BI-5026 | ||
| GSK973 |
|
Bromodomains | BRD2, BRD3, BRD4, BRDT | GSK943 | ||
| GSK620 | Bromodomains | BRD2, BRD3, BRD4, BRDT | ||||
| GSK046 | Bromodomains | BRD2, BRD3, BRD4, BRDT | ||||
| GSK789 |
|
Bromodomains | BRD2, BRD3, BRD4, BRDT | GSK791 | ||
| GSK778 | Bromodomains | BRD2, BRD3, BRD4, BRDT | ||||
| BAY-3153 |
|
GPCR | CCR1 | BAY-173 | ||
| BAY-6672 |
|
GPCR | PTGFR | BAY-403 | ||
| BI 207127 |
|
RNA polymerase | HCV NS5B | BI-7656 | ||
| BAY 1816032 |
|
Kinase | BUB1 | BAY-283 | ||
| JNJ-9350 |
|
Oxidase | SMOX | JNJ-4545 | ||
| SAFit2 |
|
Isomerase | FKBP5 | ddSAFit2 | ||
| CCT369260 |
|
Transcription factor | BCL6 | CCT393732 | ||
| JNJ-39758979 |
|
GPCR | HRH4 | JNJ-39668551 | ||
| JNJ-6204 |
|
Kinase | CSNK1D/CSNK1E | JNJ-0293 | ||
| BI-2081 |
|
GPCR | FFAR1 | BI-0340 | ||
| TP-051 |
|
GPCR | FFAR1 | TP-051n | ||
| TP-050 |
|
Ion channel | GRIN2A | TP-050n | ||
| GNE-2256 |
|
Kinase | IRAK4 | GNE-6689 | ||
| BAY1125976 |
|
Kinase | AKT1/2 | BAY-940 | ||
| JNJ-65355394 |
|
Hydrolase | OGA | JNJ-73924149 | ||
| BAY 1816032 |
|
2OG | BUB1 | BAY-283 | ||
| BI-5524 |
|
Chymotrypsin | ELANE | BI-5525 | ||
| WEB2086 |
|
GPCR | PTAFR | WEB2387 | ||
| BIBO3304 |
|
GPCR | NPY1R | BIBO3457 | ||
| SGK3-PROTAC1 |
|
Kinase | SGK3 | cisSGK3-PROTAC1 | ||
| VZ185 |
|
Bromodomain-containing protein family | BRD7, BRD9 | cisVZ185 | ||
| BAY-277 |
|
Aminopeptidase | METAP2 | BAY-8805 | ||
| BAY-6096 |
|
GPCR | ADRA2B | BAY-726 | ||
| BAY 1753011 |
|
GPCR | AVPR1A, AVPR2 | BAY-2297 | ||
| BI-8668 |
|
Sodium channels | Epithelial sodium channel (ENaC) | BI-0337 | ||
| BI-3812 |
|
Transcription factor | BCL6 | BI-5273 | ||
| BI-3802 |
|
Transcription factor | BCL6 | BI-5273 | ||
| JP3000 |
|
Nuclear hormone receptor | RXRA, RXRB, RXRG | JP3001 | ||
| TP-060 |
|
Glucosyltransferase | UGCG | TP-060n | ||
| JNJ-42226314 |
|
Serine hydrolase | MGLL | JNJ-8034 | ||
| JNJ-4355 |
|
BCL2 protein family | MCL1 | JNJ-78732576 | ||
| BAY-7081 |
|
Phoshodiesterase | PDE9A | BAY-7424 | ||
| FHT-2344 |
|
SWI/SNF | SMARCA2, SMARCA4 | FHT-5908 | ||
| BI-3231 |
|
17β-hydroxysteroid dehydrogenases | HSD17B13 | BI-0955 | ||
| BAY-826 |
|
Kinase | TIE1, TEK, DDR1, DDR2 | BAY-309 | ||
| BI-665915 |
|
Lipoxygenase | ALOX5AP | BI-0153 |