Chemical Probes

SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. SGC-developed probes are complemented by a growing set of donated high-quality chemical probes developed in industry and non-SGC laboratories. These are also available for unencumbered use.

The table below contains the entire collection of probes from SGC’s chemical probes program and donated chemical probes. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers.

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Name Structures Protein Family Target Protein Control Cellular Usage Added
TP-061 Helicases Brr2 TP-061N Yes
BI-1915 Protease CTSS BI-1920
BI-113823 GPCR BDKRB1 BI-5832
JNJ-54082730 Hydrolase PDE2A JNJ-54103985
JNJ-3738 Kinase CDK7 JNJ-6240
BAY-9835 Protease ADAMTS7, ADAMTS12 BAY-1880
Bromosporine (BSP) Bromodomains pan-Bromodomain Yes
UNC1215 Methyl Lysine Binder L3MBTL3 UNC1079 Yes
SGC0946 Methyltransferase DOT1L SGC0649 Yes
UNC0642 Methyltransferase EHMT2/G9a, EHMT1/GLP Yes
GSK343 Methyltransferase EZH2 Yes
GSK-J1 Lysine Demethylase KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B GSK-J2 (GSK-J5) Yes
IOX2 2OG PHD2 Yes
IOX1 2OG Pan-KDM Yes
PFI-1 Bromodomains BRD2, BRD3, BRD4, BRDT Yes
UNC0638 Methyltransferase EHMT2/G9a, EHMT1/GLP UNC0737 Yes
(+)-JQ1 Bromodomains BRD2, BRD3, BRD4, BRDT (-)-JQ1 Yes
MS023 Methyltransferase PRMT1, PRMT3, CARM1, PRMT6, PRMT8 MS094 Yes
MS049 Methyltransferase CARM1, PRMT6 MS049N Yes
NVS-CECR2-1 Bromodomains CECR2 NVS-CECR2-C Yes
I-BRD9 Bromodomains BRD9 Yes
BI-9564 Bromodomains BRD9, BRD7 Yes
BAY-598 Methyltransferase SMYD2 BAY-369 Yes
GSK484 Arginine deiminases PAD4 GSK106 Yes
GSK2801 Bromodomains BAZ2A, BAZ2B GSK8573 Yes
LP99 Bromodomains BRD9, BRD7 2S,3R-enantiomer Yes
NI-57 Bromodomains BRPF1, BRD1, BRPF3 Yes
PFI-4 Bromodomains BRPF1 Yes
OF-1 Bromodomains BRPF1, BRD1, BRPF3 Yes
SGC707 Methyltransferase PRMT3 XY1 Yes
BAZ2-ICR Bromodomains BAZ2A, BAZ2B Yes
OICR-9429 WD40 repeat WDR5 OICR-0547 Yes
GSK-LSD1 Lysine Demethylase KDM1A/LSD1 Yes
LLY-507 (multiple off-targets) Methyltransferase SMYD2 SGC705 Yes
PFI-3 Bromodomains SMARCA2, PBRM1, SMARCA4 PFI-3oMet Yes
A-366 Methyltransferase EHMT1/GLP, EHMT2/G9a Yes
UNC1999 Methyltransferase EZH2 UNC2400 Yes
(R)-PFI-2 Methyltransferase SETD7 (S)-PFI-2 Yes
SGC-CBP30 Bromodomains CREBBP, EP300 BDOIA513 Yes
I-CBP112 Bromodomains CREBBP, EP300 Yes
SGC3027 Methyltransferase PRMT7 SGC3027N No
SGC-GAK-1 Kinase GAK SGC-GAK-1N No
SGC-AAK1-1 Kinase AAK1, BMP2K, BIKE SGC-AAK1-1N No
BI01383298 Solute carriers SLC13A5 BI01372674 No
L-Moses Bromodomains KAT2A, KAT2B D-Moses Yes
TH-257 Kinase LIMK1, LIMK2 TH-263 No
SKI-73 Methyltransferase CARM1 SKI-73N No
PFI-5 Methyltransferase SMYD2 PFI-5N No
BAY-6035 Methyltransferase SMYD3 BAY-444 No
GSK4027 Bromodomains KAT2A, KAT2B GSK4028 No
FM-381 Kinase JAK3 FM-479 No
BAY-850 Bromodomains ATAD2 BAY-460 No
GSK8814 Bromodomains ATAD2, ATAD2B GSK8815 No
GSK6853 Bromodomains BRPF1 GSK9311 Yes
LLY-283 Methyltransferase PRMT5 LLY-284 No
A-395 WD40 repeat EED A-395N No
TP-472 Bromodomains BRD9, BRD7 TP-472N Yes
TP-064 Methyltransferase CARM1 TP-064N No
BAY-299 Bromodomains TAF1, BRD1 BAY-364 Yes
NVS-PAK1-1 Kinase PAK1 NVS-PAK1-C Yes
GSK864 Dehydrogenase IDH1 GSK990 Yes
A-196 Methyltransferase SUV420H1, SUV420H2 A-197, SGC2043 Yes
GSK591 Methyltransferase PRMT5 SGC2096 Yes
MU1700 Kinase ALK1, ALK2 MU1700NC Yes
M4K2234 Kinase ALK1, ALK2 M4K2234NC Yes
SGC-UBD253 UBD (ubiquitin binding domain) HDAC6 SGC-UBD253N Yes
CK156 Kinase STK17A, DRAK1 CKJB71 Yes
PFI-7 E3 ligase GID4 PFI-7N Yes
MRIA9 Kinase SIK1, SIK2, SIK3 MR7 Yes
Homer WD40 repeat WDR5 nc_WDR5 and nc_VHL Yes
SGC-SMARCA-BRDVIII Bromodomains PB1(5), SMARCA2/4 SGC-BRDVIII-NC No
NR162 Kinase CASK NR187 Yes
PFI-6 YEATS MLLT1, MLLT3 PFI-6N Yes
SGC-CK2-1 Kinase CSNK2A1, CSNK2A2 SGC-CK2-1N Yes
NVS-MLLT-1 YEATS MLLT1, MLLT3 NVS-iMLLT-C Yes
SGC-STK17B-1 Kinase STK17B, DRAK2 SGC-STK17B-1N No
SGC-CLK-1 Kinase CLK1, CLK2, CLK4 SGC-CLK-1N Yes
SGC-CAMKK2-1 Kinase CAMKK1, CAMKK2 SGC-CAMKK2-1N Yes
SGC6870 Methyltransferase PRMT6 SGC6870N No
UNC6934 Methyl Lysine Binder NSD2-PWWP1 UNC7145 No
MU1210 Kinase CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 MU140 Yes
NVS-BPTF-1 Bromodomains BPTF NVS-BPTF-C Yes
VinSpinIn Spindlin domains Spin1 VinSpinIC No
TP-238 Bromodomains CECR2, BPTF TP-422 No
DDR-TRK-1 Kinase DDR, TRK DDR-TRK-1N Yes
BI-9321 Methyl Lysine Binder NSD3 BI-9466 No
MRK-740 Methyltransferase PRDM9 MRK-740-NC No
SGC-UBD1031 UBD (ubiquitin binding domain) SGC-UBD1031N Yes
UNC8732 Methyl Lysine Binder NSD2 UNC8884 Yes
OICR11029 Transcription factor BCL6 OICR11600 Yes
PFI-8 YEATS YEATS PFI-8N Yes
JA310 Kinase MST3, MST4 JA262 No
SGC-GSK3-1 Kinase GSK3 SGC-CDKL5/GSK3-1N Yes
SGC-CDKL5_GSK3 Kinase CDKL5, GSK3 SGC-CDKL5/GSK3-1N Yes
SGC-CAF382-1 Kinase CDKL5 SGC-CAF268-1N No
TH-257 Kinase LIMK1, LIMK2 TH-263 No
JA397 Kinase CDK14-18 JA314 No
SGC-PI5P4Kγ/MYLK4-1 Kinase PI5P4K gamma, MYLK4 SGC-PI5P4Kγ/MYLK4-1N Yes
SGC-CK2-2 Kinase CK2/CSNK2 SGK-CK2-2N No
MSC1186 Kinase SRPK MSC5360 No
CS640 Kinase CAMK1 CS640s Yes
MU1742 Kinase CK1δ, CK1ε MU2027 Yes
BAY-805 USP (ubiquitin specific protease) USP21 BAY-728 Yes
MRK-952 Hydrolase NUDT5 MRK-952-NC Yes
MRK-990 Methyltransferase PRMT9, PRMT5 MRK-990-NC Yes
SGC-PIKFYVE-1 Kinase PIKfyve SGC-PIKFYVE-1N Yes
ABT-724 GPCR DRD4 A-769 Yes
ERKi Kinase MAPK3, MAPK1 ERKi-NC Yes
BAY-7598 Protease MMP12 BAY-694 Yes
BI 99179 Synthase FASN BI 99990 Yes
BAY-474 Kinase MET BAY-827 Yes
(R)-9s GPCR ADRA1D (S)-9s Yes
ABT-100 Transferase FNTB A-108 Yes
BTZO-1 Cytokine MIF BTZO-4 Yes
BAY-386 GPCR F2R BAY-448 Yes
BAY-707 Hydrolase NUDT1 BAY-604 Yes
A-485 Transferase EP300, CREBBP A-486 Yes
BI-9627 Solute carriers SLC9A1 BI-0054 Yes
TP-004 Protease METAP2 TPn-004 Yes
PF-05105679 Ion channel TRPM8 PF-05257137 Yes
PF-04418948 GPCR PTGER2 PF-04475866 Yes
BI-1935 Hydrolase EPHX2 BI-2049 Yes
GSM1 Protease Gamma secretase complex GSM-NC Yes
MRK-560 Protease Gamma secretase complex GSI-NC Yes
MRL-SYKi Kinase SYK MRL-SYKi-NC Yes
MRL-650 GPCR CNR1 MRL-CB1-NC Yes
CRTH2 antagonist GPCR PTGDR2 CRTH2 negative control Yes
TP-021 Transcription factor BCL6 TP-021n Yes
TP-020 Transferase MGAT2 TP-020n Yes
BAY-784 GPCR GNRHR BAY-786 Yes
BAY-1797 Ion channel P2X4 BAY-207 Yes
BI-1950 Integrin ITGAL BI-9446 Yes
BI 653048 Nuclear hormone receptor NR3C1 BI-3047 Yes
BI 639667 GPCR CCR1 BI-9307 Yes
BI-2545 Phosphodiesterase ENPP2 BI-3017 Yes
BAY-885 Kinase MAPK7 BAY-693 Yes
BI-4394 Protease MMP13 BI-4395 Yes
A-079 Ion channel TRPA1 A-226 Yes
BAY-678 Protease ELANE BAY-677 Yes
BAY-876 Solute carriers SLC2A1 BAY-588 Yes
T-26c Protease MMP13 T-26f Yes
ABT-546 GPCR EDNRA A-545 Yes
PF-04457845 Hydrolase FAAH PF-04875474 Yes
KISS1-305 GPCR KISS1R KISS1-543 Yes
A-1155463 Regulator protein BCL2L1 A-1107969 Yes
A-1211212 Regulator protein BCL2 A-1210227 Yes
IPP/CNRS-A017 Dehydrogenase DHODH IPP/CNRS-A019 Yes
MSD-M1PAM GPCR CHRM1 MSD-M1PAM-NC Yes
A-1596586 Ion channel CFTR A-1596584 Yes
MSD-CYP11B2 Cytochrome P450 CYP11B2 MSD-CYP11B2 Negative control Yes
THPP-1 Phosphodiesterase PDE10A THPP-1-NC Yes
PPTN GPCR P2RY14 PPTN-NC Yes
BAY-549 Kinase ROCK1, ROCK2 BAY-4900 Yes
TP-008 Kinase ACVR1B, TGFBR1 Al11 Yes
MLi-2 Kinase LRRK2 MLi-2-NC Yes
UCSF924 GPCR DRD4 UCSF924NC Yes
T3-CLK Kinase CLK1, CLK2, CLK3, CLK4 T3-CLK-N Yes
BAY-293 Nucleotide exchange factor SOS1 BAY-294 Yes
A-192621 GPCR EDNRB A-1806262 Yes
BI-1230 Protease HCV NS3 BI-1675 Yes
TP-024 GPCR GPR52 TP-024n Yes
BI-2540 Reverse transcriptase HIV NNRT BI-2439 Yes
BAY-390 Ion channel TRPA1 BAY-9897 Yes
BAY-069 Amino acid transaminase BCAT1, BCAT2 BAY-771 Yes
TP-030-2 Kinase RIPK1 TP-030n Yes
TP-030-1 Kinase RIPK1 TP-030n Yes
(R)-ZINC-3573 GPCR MRGPRX2 (S)-ZINC-3573 Yes
Ogerin GPCR GPR68 ZINC32547799 Yes
WM-1119 Transferase KAT6A, KAT6B WM-2474 Yes
SR-302 Kinase DDR1, DDR2, MAPK11, MAPK14 SR-301 Yes
NVS-MALT1 Protease MALT1 NVS-MALT1-C Yes
BAY-3827 Kinase PRKAA1, RPS6KA1 BAY-974 Yes
FS-694 Kinase MAPK14 FM-743 Yes
Skepinone-L Kinase MAPK14 FM-743 Yes
SR-318 Kinase MAPK14 SR-321 Yes
BAY-179 Protease Complex I BAY-070 Yes
BAY-899 GPCR LHCGR BAY-897 Yes
BAY-985 Kinase TBK1, IKBKE BAY-440 Yes
Borussertib Kinase AKT1, AKT2 RL2578 Yes
BAY-091 Kinase PIP4K2A BAY-0361 Yes
MSC-4381 Monocarboxylate transporter SLC16A3 MSC-0516 Yes
PFI-653 Hydrolase VNN1 PFI-653-N Yes
JNJ-54119936 Nuclear hormone receptor RORC JNJ-53721590 Yes
JNJ-42396302 Phosphodiesterase PDE10A JNJ-40573663 Yes
TP-040 Hydrolase OGA TP-040n Yes
8RK64 Regulator protein UCHL1 JYQ88 Yes
A-446 Hydrolase GLS A-426 Yes
BI-1942 Protease CMA1 Yes
BI 605906 Kinase IKBKB BI-5026 Yes
GSK973 Bromodomains BRD2, BRD3, BRD4, BRDT GSK943 Yes
GSK620 Bromodomains BRD2, BRD3, BRD4, BRDT Yes
GSK046 Bromodomains BRD2, BRD3, BRD4, BRDT Yes
GSK789 Bromodomains BRD2, BRD3, BRD4, BRDT GSK791 Yes
GSK778 Bromodomains BRD2, BRD3, BRD4, BRDT Yes
BAY-3153 GPCR CCR1 BAY-173 Yes
BAY-6672 GPCR PTGFR BAY-403 Yes
BI 207127 RNA polymerase HCV NS5B BI-7656 Yes
BAY 1816032 Kinase BUB1 BAY-283 Yes
JNJ-9350 Oxidase SMOX JNJ-4545 Yes
SAFit2 Isomerase FKBP5 ddSAFit2 Yes
CCT369260 Transcription factor BCL6 CCT393732 Yes
JNJ-39758979 GPCR HRH4 JNJ-39668551 Yes
JNJ-6204 Kinase CSNK1D/CSNK1E JNJ-0293 Yes
BI-2081 GPCR FFAR1 BI-0340 Yes
TP-051 GPCR FFAR1 TP-051n Yes
TP-050 Ion channel GRIN2A TP-050n Yes
GNE-2256 Kinase IRAK4 GNE-6689 Yes
BAY1125976 Kinase AKT1/2 BAY-940 Yes
JNJ-65355394 Hydrolase OGA JNJ-73924149 Yes
BAY 1816032 2OG BUB1 BAY-283 Yes
BI-5524 Chymotrypsin ELANE BI-5525 Yes
WEB2086 GPCR PTAFR WEB2387 Yes
BIBO3304 GPCR NPY1R BIBO3457 Yes
SGK3-PROTAC1 Kinase SGK3 cisSGK3-PROTAC1 Yes
VZ185 Bromodomain-containing protein family BRD7, BRD9 cisVZ185 Yes
BAY-277 Aminopeptidase METAP2 BAY-8805 Yes
BAY-6096 GPCR ADRA2B BAY-726 Yes
BAY 1753011 GPCR AVPR1A, AVPR2 BAY-2297 Yes
BI-8668 Sodium channels Epithelial sodium channel (ENaC) BI-0337 Yes
BI-3812 Transcription factor BCL6 BI-5273 Yes
BI-3802 Transcription factor BCL6 BI-5273 Yes
JP3000 Nuclear hormone receptor RXRA, RXRB, RXRG JP3001 No
TP-060 Glucosyltransferase UGCG TP-060n Yes
JNJ-42226314 Serine hydrolase MGLL JNJ-8034 Yes
JNJ-4355 BCL2 protein family MCL1 JNJ-78732576 Yes
BAY-7081 Phoshodiesterase PDE9A BAY-7424 Yes
FHT-2344 SWI/SNF SMARCA2, SMARCA4 FHT-5908 Yes
BI-3231 17β-hydroxysteroid dehydrogenases HSD17B13 BI-0955 Yes
BAY-826 Kinase TIE1, TEK, DDR1, DDR2 BAY-309 Yes
BI-665915 Lipoxygenase ALOX5AP BI-0153 Yes