SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. SGC-developed probes are complemented by a growing set of donated high-quality chemical probes developed in industry and non-SGC laboratories. These are also available for unencumbered use.
The table below contains the entire collection of probes from SGC’s chemical probes program and donated chemical probes. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers.
| Name | Structures | Protein Family | Target Protein | Control | Cellular Usage | Added |
|---|---|---|---|---|---|---|
| OICR-41103 |
|
WD40 repeat | DCAF1 | OICR-41103N | 1 µM; not to exceed 5 µM | |
| SGC-CDKL2/AAK1/BMP2K-1 |
|
Kinase | CDKL2 | CDKL2/AAK1/BMP2K -1N | ≤1 µM | |
| TP-061 |
|
Helicases | Brr2 | TP-061N | 5 µM | |
| BI-1915 |
|
Protease | CTSS | BI-1920 | ||
| BI-113823 |
|
GPCR | BDKRB1 | BI-5832 | ||
| JNJ-54082730 |
|
Hydrolase | PDE2A | JNJ-54103985 | ||
| JNJ-3738 |
|
Kinase | CDK7 | JNJ-6240 | ||
| BAY-9835 |
|
Protease | ADAMTS7, ADAMTS12 | BAY-1880 | ||
| (+)-JQ1 |
|
Bromodomains | BRD2, BRD3, BRD4, BRDT | (-)-JQ1 | ||
| Bromosporine (BSP) |
|
Bromodomains | pan-Bromodomain | |||
| GSK-J1 |
|
Lysine Demethylase | KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B | GSK-J2 (GSK-J5) | ||
| GSK343 |
|
Methyltransferase | EZH2 | |||
| IOX1 |
|
2OG | Pan-KDM | |||
| IOX2 |
|
2OG | PHD2 | |||
| PFI-1 |
|
Bromodomains | BRD2, BRD3, BRD4, BRDT | |||
| SGC0946 |
|
Methyltransferase | DOT1L | SGC0649 | ||
| UNC0638 |
|
Methyltransferase | EHMT2/G9a, EHMT1/GLP | UNC0737 | ||
| UNC0642 |
|
Methyltransferase | EHMT2/G9a, EHMT1/GLP | |||
| UNC1215 |
|
Methyl Lysine Binder | L3MBTL3 | UNC1079 | ||
| (R)-PFI-2 |
|
Methyltransferase | SETD7 | (S)-PFI-2 | ||
| A-366 |
|
Methyltransferase | EHMT1/GLP, EHMT2/G9a | |||
| BAY-598 |
|
Methyltransferase | SMYD2 | BAY-369 | ||
| BAZ2-ICR |
|
Bromodomains | BAZ2A, BAZ2B | |||
| BI-9564 |
|
Bromodomains | BRD9, BRD7 | |||
| GSK-LSD1 |
|
Lysine Demethylase | KDM1A/LSD1 | |||
| GSK2801 |
|
Bromodomains | BAZ2A, BAZ2B | GSK8573 | ||
| GSK484 |
|
Arginine deiminases | PAD4 | GSK106 | ||
| I-BRD9 |
|
Bromodomains | BRD9 | |||
| I-CBP112 |
|
Bromodomains | CREBBP, EP300 | |||
| LLY-507 (multiple off-targets) |
|
Methyltransferase | SMYD2 | SGC705 | ||
| LP99 |
|
Bromodomains | BRD9, BRD7 | 2S,3R-enantiomer | ||
| MS023 |
|
Methyltransferase | PRMT1, PRMT3, CARM1, PRMT6, PRMT8 | MS094 | ||
| MS049 |
|
Methyltransferase | CARM1, PRMT6 | MS049N | ||
| NI-57 |
|
Bromodomains | BRPF1, BRD1, BRPF3 | 1 µM | ||
| NVS-CECR2-1 |
|
Bromodomains | CECR2 | NVS-CECR2-C | 1 µM | |
| OF-1 |
|
Bromodomains | BRPF1, BRD1, BRPF3 | <5 µM | ||
| OICR-9429 |
|
WD40 repeat | WDR5 | OICR-0547 | ||
| PFI-3 |
|
Bromodomains | SMARCA2, PBRM1, SMARCA4 | PFI-3oMet | ||
| PFI-4 |
|
Bromodomains | BRPF1 | 1 µM | ||
| SGC-CBP30 |
|
Bromodomains | CREBBP, EP300 | BDOIA513 | ||
| SGC707 |
|
Methyltransferase | PRMT3 | XY1 | ||
| UNC1999 |
|
Methyltransferase | EZH2 | UNC2400 | ||
| A-196 |
|
Methyltransferase | SUV420H1, SUV420H2 | SGC2043 | ||
| A-395 |
|
WD40 repeat | EED | A-395N | ||
| BAY-299 |
|
Bromodomains | TAF1, BRD1 | BAY-364 | ||
| BAY-6035 |
|
Methyltransferase | SMYD3 | BAY-444 | ||
| BAY-850 |
|
Bromodomains | ATAD2 | BAY-460 | ||
| BI01383298 |
|
Solute carriers | SLC13A5 | BI01372674 | ||
| FM-381 |
|
Kinase | JAK3 | FM-479 | ||
| GSK4027 |
|
Bromodomains | KAT2A, KAT2B | GSK4028 | ||
| GSK591 |
|
Methyltransferase | PRMT5 | SGC2096 | ||
| GSK6853 |
|
Bromodomains | BRPF1 | GSK9311 | < 1 µM | |
| GSK864 |
|
Dehydrogenase | IDH1 | GSK990 | ||
| GSK8814 |
|
Bromodomains | ATAD2, ATAD2B | GSK8815 | ||
| L-Moses |
|
Bromodomains | KAT2A, KAT2B | D-Moses | ||
| LLY-283 |
|
Methyltransferase | PRMT5 | LLY-284 | ||
| NVS-PAK1-1 |
|
Kinase | PAK1 | NVS-PAK1-C | ||
| PFI-5 |
|
Methyltransferase | SMYD2 | PFI-5N | ||
| SGC-AAK1-1 |
|
Kinase | AAK1, BMP2K, BIKE | SGC-AAK1-1N | ||
| SGC-GAK-1 |
|
Kinase | GAK | SGC-GAK-1N | ||
| SGC3027 |
|
Methyltransferase | PRMT7 | SGC3027N | ||
| SKI-73 |
|
Methyltransferase | CARM1 | SKI-73N | ||
| TH-257 |
|
Kinase | LIMK1, LIMK2 | TH-263 | ||
| TP-064 |
|
Methyltransferase | CARM1 | TP-064N | ||
| TP-472 |
|
Bromodomains | BRD9, BRD7 | TP-472N | ||
| BI-9321 |
|
Methyl Lysine Binder | NSD3 | BI-9466 | 0.5 µM - 20 µM | |
| CK156 |
|
Kinase | STK17A, DRAK1 | CKJB71 | 5 µM | |
| DDR-TRK-1 |
|
Kinase | DDR, TRK | DDR-TRK-1N | 5 µM | |
| Homer |
|
WD40 repeat | WDR5 | nc_WDR5 and nc_VHL | 1 µM | |
| M4K2234 |
|
Kinase | ALK1, ALK2 | M4K2234NC | 1 µM | |
| MRIA9 |
|
Kinase | SIK1, SIK2, SIK3 | MR7 | 10 µM | |
| MRK-740 |
|
Methyltransferase | PRDM9 | MRK-740-NC | 3 µM | |
| MU1210 |
|
Kinase | CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 | MU140 | 1 µM | |
| MU1700 |
|
Kinase | ALK1, ALK2 | MU1700NC | ||
| NR162 |
|
Kinase | CASK | NR187 | 10 µM | |
| NVS-BPTF-1 |
|
Bromodomains | BPTF | NVS-BPTF-C | < 1 µM | |
| NVS-MLLT-1 |
|
YEATS | MLLT1, MLLT3 | NVS-iMLLT-C | 1 µM | |
| PFI-6 |
|
YEATS | MLLT1, MLLT3 | PFI-6N | ||
| PFI-7 |
|
E3 ligase | GID4 | PFI-7N | ||
| SGC-CAMKK2-1 |
|
Kinase | CAMKK1, CAMKK2 | SGC-CAMKK2-1N | ||
| SGC-CK2-1 |
|
Kinase | CSNK2A1, CSNK2A2 | SGC-CK2-1N | ||
| SGC-CLK-1 |
|
Kinase | CLK1, CLK2, CLK4 | SGC-CLK-1N | ||
| SGC-SMARCA-BRDVIII |
|
Bromodomains | PB1(5), SMARCA2/4 | SGC-BRDVIII-NC | 10 µM | |
| SGC-STK17B-1 |
|
Kinase | STK17B, DRAK2 | SGC-STK17B-1N | ||
| SGC-UBD253 |
|
UBD (ubiquitin binding domain) | HDAC6 | SGC-UBD253N | ||
| SGC6870 |
|
Methyltransferase | PRMT6 | SGC6870N | ||
| TP-238 |
|
Bromodomains | CECR2, BPTF | TP-422 | < 2 µM | |
| UNC6934 |
|
Methyl Lysine Binder | NSD2-PWWP1 | UNC7145 | ||
| VinSpinIn |
|
Spindlin domains | Spin1 | VinSpinIC | 0.5 µM - 3 µM | |
| BAY-805 |
|
USP (ubiquitin specific protease) | USP21 | BAY-728 | ||
| CS640 |
|
Kinase | CAMK1 | CS640s | < 1 µM | |
| JA310 |
|
Kinase | MST3, MST4 | JA262 | < 1 µM | |
| JA397 |
|
Kinase | CDK14-18 | JA314 | < 1 µM | |
| LIJTF500025 |
|
Kinase | LIMK1, LIMK2 | LIJTF500120 | < 1 µM | |
| MRK-952 |
|
Hydrolase | NUDT5 | MRK-952-NC | ||
| MRK-990 |
|
Methyltransferase | PRMT9, PRMT5 | MRK-990-NC | ||
| MSC1186 |
|
Kinase | SRPK | MSC5360 | < 1 µM | |
| MU1742 |
|
Kinase | CK1δ, CK1ε | MU2027 | ||
| OICR11029 |
|
Transcription factor | BCL6 | OICR11600 | ||
| PFI-8 |
|
YEATS | YEATS | PFI-8N | ||
| SGC-CAF382-1 |
|
Kinase | CDKL5 | SGC-CAF268-1N | ≤ 100 nM | |
| SGC-CDKL5_GSK3 |
|
Kinase | CDKL5, GSK3 | SGC-CDKL5/GSK3-1N | ||
| SGC-CK2-2 |
|
Kinase | CK2/CSNK2 | SGK-CK2-2N | ||
| SGC-GSK3-1 |
|
Kinase | GSK3 | SGC-CDKL5/GSK3-1N | ||
| SGC-PI5P4Kγ/MYLK4-1 |
|
Kinase | PI5P4K gamma, MYLK4 | SGC-PI5P4Kγ/MYLK4-1N | ||
| SGC-PIKFYVE-1 |
|
Kinase | PIKfyve | SGC-PIKFYVE-1N | ||
| SGC-UBD1031 |
|
UBD (ubiquitin binding domain) | USP16/HDAC6 | SGC-UBD1031N | 10 µM | |
| UNC8732 |
|
Methyl Lysine Binder | NSD2 | UNC8884 | ||
| ABT-724 |
|
GPCR | DRD4 | A-769 | ||
| BAY-474 |
|
Kinase | MET | BAY-827 | ||
| BAY-7598 |
|
Protease | MMP12 | BAY-694 | ||
| BI 99179 |
|
Synthase | FASN | BI 99990 | ||
| ERKi |
|
Kinase | MAPK3, MAPK1 | ERKi-NC | ||
| (R)-9s |
|
GPCR | ADRA1D | (S)-9s | ||
| A-485 |
|
Transferase | EP300, CREBBP | A-486 | ||
| ABT-100 |
|
Transferase | FNTB | A-108 | ||
| BAY-386 |
|
GPCR | F2R | BAY-448 | ||
| BAY-707 |
|
Hydrolase | NUDT1 | BAY-604 | ||
| BI-1935 |
|
Hydrolase | EPHX2 | BI-2049 | ||
| BI-9627 |
|
Solute carriers | SLC9A1 | BI-0054 | ||
| BTZO-1 |
|
Cytokine | MIF | BTZO-4 | ||
| CRTH2 antagonist |
|
GPCR | PTGDR2 | CRTH2 negative control | ||
| GSM1 |
|
Protease | Gamma secretase complex | GSM-NC | ||
| MRK-560 |
|
Protease | Gamma secretase complex | GSI-NC | ||
| MRL-650 |
|
GPCR | CNR1 | MRL-CB1-NC | ||
| MRL-SYKi |
|
Kinase | SYK | MRL-SYKi-NC | ||
| PF-04418948 |
|
GPCR | PTGER2 | PF-04475866 | ||
| PF-05105679 |
|
Ion channel | TRPM8 | PF-05257137 | ||
| TP-004 |
|
Protease | METAP2 | TPn-004 | ||
| A-079 |
|
Ion channel | TRPA1 | A-226 | ||
| ABT-546 |
|
GPCR | EDNRA | A-545 | ||
| BAY-1797 |
|
Ion channel | P2X4 | BAY-207 | ||
| BAY-678 |
|
Protease | ELANE | BAY-677 | ||
| BAY-784 |
|
GPCR | GNRHR | BAY-786 | ||
| BAY-876 |
|
Solute carriers | SLC2A1 | BAY-588 | ||
| BAY-885 |
|
Kinase | MAPK7 | BAY-693 | ||
| BI 639667 |
|
GPCR | CCR1 | BI-9307 | ||
| BI 653048 |
|
Nuclear hormone receptor | NR3C1 | BI-3047 | ||
| BI-1950 |
|
Integrin | ITGAL | BI-9446 | ||
| BI-2545 |
|
Phosphodiesterase | ENPP2 | BI-3017 | ||
| BI-4394 |
|
Protease | MMP13 | BI-4395 | ||
| KISS1-305 |
|
GPCR | KISS1R | KISS1-543 | ||
| PF-04457845 |
|
Hydrolase | FAAH | PF-04875474 | ||
| T-26c |
|
Protease | MMP13 | T-26f | ||
| TP-020 |
|
Transferase | MGAT2 | TP-020n | ||
| TP-021 |
|
Transcription factor | BCL6 | TP-021n | ||
| A-1155463 |
|
Regulator protein | BCL2L1 | A-1107969 | ||
| A-1211212 |
|
Regulator protein | BCL2 | A-1210227 | ||
| A-1596586 |
|
Ion channel | CFTR | A-1596584 | ||
| A-192621 |
|
GPCR | EDNRB | A-1806262 | ||
| BAY-293 |
|
Nucleotide exchange factor | SOS1 | BAY-294 | ||
| BAY-549 |
|
Kinase | ROCK1, ROCK2 | BAY-4900 | ||
| BI-1230 |
|
Protease | HCV NS3 | BI-1675 | ||
| IPP/CNRS-A017 |
|
Dehydrogenase | DHODH | IPP/CNRS-A019 | ||
| MLi-2 |
|
Kinase | LRRK2 | MLi-2-NC | ||
| MSD-CYP11B2 |
|
Cytochrome P450 | CYP11B2 | MSD-CYP11B2 Negative control | ||
| MSD-M1PAM |
|
GPCR | CHRM1 | MSD-M1PAM-NC | ||
| PPTN |
|
GPCR | P2RY14 | PPTN-NC | ||
| T3-CLK |
|
Kinase | CLK1, CLK2, CLK3, CLK4 | T3-CLK-N | ||
| THPP-1 |
|
Phosphodiesterase | PDE10A | THPP-1-NC | ||
| TP-008 |
|
Kinase | ACVR1B, TGFBR1 | Al11 | ||
| TP-024 |
|
GPCR | GPR52 | TP-024n | ||
| UCSF924 |
|
GPCR | DRD4 | UCSF924NC | ||
| (R)-ZINC-3573 |
|
GPCR | MRGPRX2 | (S)-ZINC-3573 | ||
| BAY-069 |
|
Amino acid transaminase | BCAT1, BCAT2 | BAY-771 | ||
| BAY-179 |
|
Protease | Complex I | BAY-070 | ||
| BAY-3827 |
|
Kinase | PRKAA1, RPS6KA1 | BAY-974 | ||
| BAY-390 |
|
Ion channel | TRPA1 | BAY-9897 | ||
| BAY-899 |
|
GPCR | LHCGR | BAY-897 | ||
| BAY-985 |
|
Kinase | TBK1, IKBKE | BAY-440 | ||
| BI-2540 |
|
Reverse transcriptase | HIV NNRT | BI-2439 | ||
| FS-694 |
|
Kinase | MAPK14 | FM-743 | ||
| NVS-MALT1 |
|
Protease | MALT1 | NVS-MALT1-C | ||
| Ogerin |
|
GPCR | GPR68 | ZINC32547799 | ||
| Skepinone-L |
|
Kinase | MAPK14 | FM-743 | ||
| SR-302 |
|
Kinase | DDR1, DDR2, MAPK11, MAPK14 | SR-301 | ||
| SR-318 |
|
Kinase | MAPK14 | SR-321 | ||
| TP-030-1 |
|
Kinase | RIPK1 | TP-030n | ||
| TP-030-2 |
|
Kinase | RIPK1 | TP-030n | ||
| WM-1119 |
|
Transferase | KAT6A, KAT6B | WM-2474 | ||
| 8RK64 |
|
Regulator protein | UCHL1 | JYQ88 | ||
| A-446 |
|
Hydrolase | GLS | A-426 | ||
| BAY-091 |
|
Kinase | PIP4K2A | BAY-0361 | ||
| BAY-3153 |
|
GPCR | CCR1 | BAY-173 | ||
| BAY-6672 |
|
GPCR | PTGFR | BAY-403 | ||
| BI 207127 |
|
RNA polymerase | HCV NS5B | BI-7656 | ||
| BI 605906 |
|
Kinase | IKBKB | BI-5026 | ||
| BI-1942 | Protease | CMA1 | ||||
| Borussertib |
|
Kinase | AKT1, AKT2 | RL2578 | ||
| GSK046 | Bromodomains | BRD2, BRD3, BRD4, BRDT | ||||
| GSK620 | Bromodomains | BRD2, BRD3, BRD4, BRDT | ||||
| GSK778 | Bromodomains | BRD2, BRD3, BRD4, BRDT | ||||
| GSK789 |
|
Bromodomains | BRD2, BRD3, BRD4, BRDT | GSK791 | ||
| GSK973 |
|
Bromodomains | BRD2, BRD3, BRD4, BRDT | GSK943 | ||
| JNJ-42396302 | Phosphodiesterase | PDE10A | JNJ-40573663 | |||
| JNJ-54119936 |
|
Nuclear hormone receptor | RORC | JNJ-53721590 | ||
| MSC-4381 |
|
Monocarboxylate transporter | SLC16A3 | MSC-0516 | ||
| PFI-653 |
|
Hydrolase | VNN1 | PFI-653-N | ||
| TP-040 |
|
Hydrolase | OGA | TP-040n | ||
| BAY 1816032 |
|
Kinase | BUB1 | BAY-283 | ||
| BAY1125976 |
|
Kinase | AKT1/2 | BAY-940 | ||
| BI-2081 |
|
GPCR | FFAR1 | BI-0340 | ||
| CCT369260 |
|
Transcription factor | BCL6 | CCT393732 | ||
| GNE-2256 |
|
Kinase | IRAK4 | GNE-6689 | ||
| JNJ-39758979 |
|
GPCR | HRH4 | JNJ-39668551 | ||
| JNJ-6204 |
|
Kinase | CSNK1D/CSNK1E | JNJ-0293 | ||
| JNJ-65355394 |
|
Hydrolase | OGA | JNJ-73924149 | ||
| JNJ-9350 |
|
Oxidase | SMOX | JNJ-4545 | ||
| SAFit2 |
|
Isomerase | FKBP5 | ddSAFit2 | ||
| TP-050 |
|
Ion channel | GRIN2A | TP-050n | ||
| TP-051 |
|
GPCR | FFAR1 | TP-051n | ||
| BAY 1816032 |
|
2OG | BUB1 | BAY-283 | ||
| BAY-277 |
|
Aminopeptidase | METAP2 | BAY-8805 | ||
| BI-5524 |
|
Chymotrypsin | ELANE | BI-5525 | ||
| BIBO3304 |
|
GPCR | NPY1R | BIBO3457 | ||
| SGK3-PROTAC1 |
|
Kinase | SGK3 | cisSGK3-PROTAC1 | ||
| VZ185 |
|
Bromodomain-containing protein family | BRD7, BRD9 | cisVZ185 | ||
| WEB2086 |
|
GPCR | PTAFR | WEB2387 | ||
| BAY 1753011 |
|
GPCR | AVPR1A, AVPR2 | BAY-2297 | ||
| BAY-6096 |
|
GPCR | ADRA2B | BAY-726 | ||
| BI-3802 |
|
Transcription factor | BCL6 | BI-5273 | ||
| BI-3812 |
|
Transcription factor | BCL6 | BI-5273 | ||
| BI-8668 |
|
Sodium channels | Epithelial sodium channel (ENaC) | BI-0337 | ||
| JP3000 |
|
Nuclear hormone receptor | RXRA, RXRB, RXRG | JP3001 | ||
| BAY-7081 |
|
Phoshodiesterase | PDE9A | BAY-7424 | ||
| JNJ-42226314 |
|
Serine hydrolase | MGLL | JNJ-8034 | ||
| JNJ-4355 |
|
BCL2 protein family | MCL1 | JNJ-78732576 | ||
| TP-060 |
|
Glucosyltransferase | UGCG | TP-060n | ||
| BI-3231 |
|
17β-hydroxysteroid dehydrogenases | HSD17B13 | BI-0955 | ||
| FHT-2344 |
|
SWI/SNF | SMARCA2, SMARCA4 | FHT-5908 | ||
| BAY-826 |
|
Kinase | TIE1, TEK, DDR1, DDR2 | BAY-309 | ||
| BI-665915 |
|
Lipoxygenase | ALOX5AP | BI-0153 |